A5058793403- Lymphatic System and Diseases
- Neuroblastoma Research and Treatments
- Angiogenesis and VEGF in Cancer
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Melanoma and MAPK Pathways
- Sympathectomy and Hyperhidrosis Treatments
- Immune Cell Function and Interaction
- Hippo pathway signaling and YAP/TAZ
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Lymphatic Disorders and Treatments
- Glioma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Vascular Malformations Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Nitric Oxide and Endothelin Effects
- Cutaneous lymphoproliferative disorders research
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations and Hemangiomas
- Sarcoma Diagnosis and Treatment
University of Göttingen
2007-2024
Universitätsmedizin Göttingen
2004-2023
University of Illinois Chicago
2019
Medical University of Graz
2013
University of Würzburg
1997-2012
University of Kentucky
2010
Universitätsklinikum Würzburg
2008-2010
Helmholtz Centre for Infection Research
2010
Hautklinik Heidelberg
2002-2005
Technical University of Munich
2004
Coronary heart disease (CHD) is based on the development of atherosclerosis in coronary arteries. Shear stress-induced endothelial nitric oxide (NO) release not only contributes to local blood pressure control but also effectively helps retard atherosclerosis. Therefore, functionally relevant polymorphisms NO synthase (NOS-3) gene may contribute CHD. NOS-3 expression was analyzed cells isolated from umbilical cords genotyped for -786C/T single nucleotide polymorphism (SNP) human nos-3 gene....
Emerging evidence suggests that nitrogen-containing bisphosphonates have direct and indirect anticancer effects including immunomodulatory effects. Using in vivo targeting of bisphosphonate-reactive γδ T cells by adding low-dose interleukin-2 to zoledronic acid, we evaluated the safety, pharmacodynamics, antitumor activity this immunotherapy approach 21 adults with advanced malignancies (renal cell carcinoma [RCC], malignant melanoma, acute myeloid leukemia). A total 58 treatment cycles were...
Lymphatic malformations (LM) are characterized by the overgrowth of lymphatic vessels during pre- and postnatal development. Macrocystic, microcystic combined forms LM known. The cysts lined endothelial cells (LECs). Resection sclerotherapy most common treatment methods. Recent studies performed on specimens in United States America have identified activating mutations phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene LM. However, whole tissue but not...
Malignant melanoma of the uvea is remarkable for purely haematogenous dissemination and its tendency to metastasise liver. Although liver involved in up 95% patients, 50% these also develop extrahepatic metastases, most often lungs, bone, skin, brain. The only effective treatments reported date relied on hepatic arterial chemoembolisation or -perfusion. objective this study was establish a therapy protocol addressing patients with both sole involvement systemic disease. Forty-eight...
Abstract Purpose: Recently, gene amplification and overexpression of KIT as well activating mutations in the have been described to occur certain subsets melanoma. These findings suggest a potential target for therapy with imatinib mesylate these melanomas. To date, data on status uveal melanoma (UM) is limited. Experimental Design: We analyzed expression protein (CD117, c-kit) its ligand, stem cell factor (SCF), primary metastatic UM. Results: By immunohistochemistry, SCF-positive tumor...
// Prisca Exertier 1,2 , Sophie Javerzat Baigang Wang 3,8 Mélanie Franco John Herbert 4 Natalia Platonova Marie Winandy 5 Nadège Pujol Olivier Nivelles 6 Sandra Ormenese 7 Virginie Godard Jürgen Becker 8 Roy Bicknell Raphael Pineau 9 Jörg Wilting 8* Andreas Bikfalvi 1,2* Martin Hagedorn 1 Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence, France 2 INSERM, 3 Ruhr-Universität Bochum, Medizinische Fakultät; Abt. f. Anatomie und Embryologie, D-44780 Germany...
Abstract Background Burkitt lymphoma (BL) is an aggressive malignancy that arises from B-cells and belongs to the group of Non-Hodgkin lymphomas (NHL). Due lack appropriate in vivo models NHL research mainly performed vitro . Here, we studied use chick chorioallantoic membrane (CAM) for generation human BL xenograft tumors, which compared with known characteristics disease. Methods In order generate experimental inoculated BL2B95 BL2-GFP cells on CAM. xenograft-tumors were grown seven days...
The vascular endothelial growth factor (VEGF) family of secreted proteins and their receptors are major regulators blood vessel development (hemangiogenesis) lymphatic (lymphangiogenesis). VEGF acts through a complex system receptor tyrosine kinases, which can be membrane bound or soluble. New data concerning the still emerging, thus contributing to complexity system. Very recently soluble form VEGFR‐2, termed sVEGFR‐2, is result alternative splicing, has been discovered. Earlier, it shown...
Tumor progression correlates with the induction of a dense supply blood vessels and formation peritumoral lymphatics. Hemangiogenesis lymphangiogenesis are potently regulated by members vascular endothelial growth factor (VEGF) family. Previous studies have indicated upregulation VEGF-A -C in progressed neuroblastoma, however, quantification was performed using semiquantitative methods, or patients who had received radiotherapy chemotherapy were studied.We analyzed primary neuroblastoma from...
Abstract Stanniocalcin 2 (STC2) is a secreted glycoprotein of as yet unknown functions. We investigated STC2 in human neuroblastoma, the most common solid extra‐cranial tumor infancy. In primary samples, we found that expression associated with metastatic Stages 4 and 4s MYCN expression. vitro, however, demonstrate cell proliferation reduced by due to an increase basal apoptosis rate transfected cells. On other hand, vitro assays showed STC2‐transfected neuroblastoma cells have increased...
Abstract Development of lymphatics takes place during embryogenesis, wound healing, inflammation, and cancer. We previously showed that Wnt5a is an essential regulator lymphatic development in the dermis mice, however, mechanisms action remained unclear. Here, whole-mount immunostaining shows embryonic day (ED) 18.5 Wnt5a-null mice possess non-functional, cyst-like often blood-filled lymphatics, contrast to slender, interconnected networks +/− wild-type (wt) mice. then compared endothelial...
Lymphedema (LE) affects millions of people worldwide. It is a chronic progressive disease with massive development fibrosclerosis when untreated. There no pharmacological treatment lymphedema. The associated swelling the interstitium affected organ, mostly arm or leg, impressive adipose tissue, fibrosis and sclerosis accumulation huge amounts collagen, Papillomatosis cutis. Malnutrition reduced oxygenation tissues hallmark Here, we investigated if hypoxia lymphatic endothelial cells (LECs)...
Millions of patients suffer from lymphedema worldwide. Supporting the contractility lymphatic collectors is an attractive target for pharmacological therapy lymphedema. However, lymphatics have mostly been studied in animals, while cellular and molecular characteristics human are largely unknown. We epifascial thigh, which were isolated autologous transplantations. Our immunohistological studies identify additional markers LECs (vimentin, CCBE1). show confirm differences between initial...
Abstract Neuroblastoma is the most common extracranial childhood tumor. High expression of activin A associated with a favorable prognosis, but contributing mechanisms have remained unclear. Our previous demonstration A–mediated up-regulation keratoepithelin led to consideration that could modulate neuroblastoma growth and/or progression. We report here enhanced in human cells suppresses cell cohesion and adhesion various extracellular matrix proteins it inhibits proliferation invasion vitro...
Burkitt lymphoma is a rare malignancy arising from B cells. Current chemotherapeutic regimens achieve excellent overall survival rates in children, but less impressive adults. There are cases with poor outcome caused by toxic effects of the therapy, tumor lysis syndrome, or metastatic spread lymphomas to central nervous system. Modulators reactive oxygen species currently discussed as potential drugs for treatment cancer. The NADPH oxidase 4 inhibitor imipramine-blue might satisfy...
Summary The epidermal cells of hypocotyls from etiolated cucumber seedlings are not constitutively competent for elicitation the rapid H 2 O defense response. However, elicitor competence developed while conditioning surface‐abraded by rotating them in buffer 4 h. Competence development was greatly potentiated inducers systemic acquired resistance and suppressed specific inhibitors proteasome activity, clasto ‐lactacystin β‐lactone (LAC) carboxybenzoyl‐ l ‐leucyl‐ ‐leucinal (LLL). In freshly...
The essential functions of Reelin for the migratory behaviour neuroblasts in central nervous system are well documented. Its role dissemination neuronal tumours peripheral has not been studied detail. Here, we examined neuroblastoma (NB), a tumour derived from sympathoadrenal cells neural crest origin. We expression Reelin, its receptors VLDLR and LRP8 adapter protein DAB1 primary samples cell lines. used real-time RT-PCR, immunohistology western blot analysis. In NB lines effects all-trans...