A5011340947- Lymphatic System and Diseases
- Reconstructive Surgery and Microvascular Techniques
- Bone fractures and treatments
- Sympathectomy and Hyperhidrosis Treatments
- Body Contouring and Surgery
- Reconstructive Facial Surgery Techniques
- Muscle activation and electromyography studies
- Vascular Malformations and Hemangiomas
- Diagnosis and Treatment of Venous Diseases
- Skin and Cellular Biology Research
- Plasma Applications and Diagnostics
- Lymphatic Disorders and Treatments
- Cancer Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Wound Healing and Treatments
- Skin Diseases and Diabetes
- Systemic Sclerosis and Related Diseases
- Burn Injury Management and Outcomes
- Genital Health and Disease
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Myofascial pain diagnosis and treatment
- Surgical site infection prevention
- Dupuytren's Contracture and Treatments
Universitätsmedizin Göttingen
2011-2025
University Medical Center Hamburg-Eppendorf
2024
University of Göttingen
2011-2023
University Medical Center
2022
Plastic Surgery Hospital
2020
University Medical Center Freiburg
2005-2011
University of Freiburg
2006-2009
Medizinische Hochschule Hannover
1999-2002
Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
2002
Klinikum am Weissenhof
1998-2000
Abstract Lipedema is a chronic adipose tissue disorder characterized by the disproportional subcutaneous deposition of fat and commonly misdiagnosed as lymphedema or obesity. The molecular determinants lipedema remain largely unknown only speculations exist regarding lymphatic system involvement. aim present study to characterize vascular involvement in established lipedema. histological characterization was conducted on anatomically-matched skin biopsies well serum samples from eleven ten...
Abstract Chronic lymphedema is a debilitating complication of cancer diagnosis and therapy poses many challenges for health care professionals. It remains poorly understood condition that has the potential to occur after any intervention affecting lymph node drainage mechanism. Microsurgical vessel transplantation increasingly recognized as promising method bypassing obstructed pathways promoting long‐term reduction edema in affected limb. A detailed review 14 patients with postoperative...
Introduction Up to one-fifth of breast cancer survivors will develop chronic cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard treatment. However, it mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) vascularised lymph node transfer (VLNT) are microsurgical techniques that aim restore lymphatic drainage. This international randomised trial aims evaluate advantages interventions...
Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat in lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish disease exist, leading a large number undiagnosed misdiagnosed patients. To unravel distinct characteristic lipedema we performed lipidomic analysis serum versus anatomically- body mass index (BMI)-matched control Both groups showed significant changes regarding...
Lipedema, lipohypertrophy and secondary lymphedema are three conditions characterized by disproportionate subcutaneous fat accumulation affecting the extremities. Despite apparent similarities differences among their phenotypes, a comprehensive histological molecular comparison does not yet exist, supporting idea that there is an insufficient understanding of particularly lipohypertrophy. In our study, we performed analysis in anatomically-, BMI- gender-matched samples lipedema, versus...
The microcirculatory response of intact human skin to exposure with diCAP for different durations a focus on the effect implied mechanical pressure during plasma treatment was investigated.Local relative hemoglobin, blood flow velocity, tissue oxygen saturation, and were monitored noninvasively up 1 hour in 1-2 mm depth by optical techniques, as well temperature, pH values, moisture before after stimulation. experimental protocol (N = 10) set differentiate between pressure- plasma-induced...
High serum concentrations of procalcitonin (PCT), the 116 amino acid precursor protein hormone calcitonin, have been found in patients with various bacterial infections, particularly those sepsis. Because recent reports shown that PCT constitutes a useful parameter for diagnosis sepsis several clinical conditions, temporal analysis plasma 19 severe burns (median body surface area burned, 32%) was conducted retrospectively. Nine were classified as septic on basis standardized and laboratory...
Millions of patients suffer from lymphedema worldwide. Supporting the contractility lymphatic collectors is an attractive target for pharmacological therapy lymphedema. However, lymphatics have mostly been studied in animals, while cellular and molecular characteristics human are largely unknown. We epifascial thigh, which were isolated autologous transplantations. Our immunohistological studies identify additional markers LECs (vimentin, CCBE1). show confirm differences between initial...
Lipedema is a chronic and progressive adipose tissue disorder, characterized by the painful disproportionate increase of subcutaneous fat in lower and/or upper extremities. While distinct immune cell infiltration known hallmark disease, its role onset development lipedema remains unclear. To analyze macrophage composition involved signaling pathways, anatomically matched control samples were collected intra-operatively from gender- BMI-matched patients, Stromal Vascular Fraction (SVF) was...
Abstract Introduction of the Vacuum‐Assisted Closure (V.A.C.) system has revolutionized approach to a multitude clinical settings. Yet, its use precludes adequate monitoring skin‐grafted free flaps, thus, making reliable essential if broad application is aspired. In study, usefulness combination V.A.C. and implantable Doppler probe was critically evaluated in patients with microsurgical lower extremity reconstruction. We retrospectively analyzed five consecutive treated our department from...
Introduction: We aim to explore potentials and modalities of cold atmospheric pressure plasma (CAP) for the subsequent development therapies targeting an increased perfusion lower leg skin tissue. In this study, we addressed question whether microcirculation enhancement is restricted tissue in direct contact with or if adjacent might also benefit. Methods: A dielectric barrier discharge (DBD)-generated CAP device exhibiting electrode area 27.5 cm² was used treat anterior ten healthy subjects...
Background: Stewart-Treves syndrome is a rare complication of breast cancer treatment, representing lymphangiosarcoma commonly associated with lymphedema and severely impacting patient's outcome. The tumor typically develops in the atrophic, pachydermatous, hyperkeratotic skin limbs affected by long-standing lymphedema. Clinical data management have rarely been published. Methods Results: In period between 1980 2009, ten patients were diagnosed treated at Foeldiklinik, Hinterzarten, Germany....
The optimal surgical treatment for lymphedema is still subject of intensive research. Therefore, it vital to investigate what significance lymphovenous anastomosis (LVA) has in this context.This study aims determine the short- and long-term results as well most important factors that can improve outcomes after LVA.This includes a complete data set 26 patients who received LVA therapy-resistant lymphedema. Patients were followed up an average 23 months.50% reported subjective improvement....
A subgroup of grossly obese patients may develop a large hanging abdominal apron, panniculus morbidus, which can contain an element lymphoedema. This hinders normal activities and prevents adequate hygiene. We reviewed published reports found that the complications result from resection had been well described, but presence lymphoedema possible benefit appropriate physiotherapy was not addressed. Our first aim to assess our overall morbidity. Secondly we assessed whether perioperative...
Abstract Background Initial lymphatic vessels do not have a continuous basement membrane. Therefore, the ability of endothelial cells (LECs) to produce extracellular matrix (ECM) has received little attention. Untreated lymphedema is chronic disease that progresses massive fibrosclerosis in advanced stages. Expansion intercellular space and cause hypoxia, which also affects LECs. Results We studied expression genes human LECs vitro by RNA sequencing, analyzed effects hypoxia (1% O 2 ) vs....