A5061814935- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Angiogenesis and VEGF in Cancer
- 3D Printing in Biomedical Research
- Body Contouring and Surgery
- Breast Implant and Reconstruction
- Molecular Biology Techniques and Applications
- Orthopedic Surgery and Rehabilitation
- Surgical Sutures and Adhesives
- Periodontal Regeneration and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Burn Injury Management and Outcomes
- Biomedical Ethics and Regulation
- Body Image and Dysmorphia Studies
- Lymphatic System and Diseases
- Dermatologic Treatments and Research
- Nerve injury and regeneration
- Bone fractures and treatments
- Organ and Tissue Transplantation Research
- Digital Imaging in Medicine
- Nerve Injury and Rehabilitation
Technical University of Munich
2016-2025
Klinikum rechts der Isar
2016-2025
Witten/Herdecke University
2023
Huazhong University of Science and Technology
2022
Weatherford College
2022
Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
2018
Fondazione Lombardia per l’Ambiente
2017
München Klinik
2009-2016
University of Lübeck
2002-2012
University Hospital Schleswig-Holstein
2004-2011
Human adipose stem cells (ASCs) have emerged as a promising treatment paradigm for skin wounds. Recent works demonstrate that the therapeutic effect of is partially mediated by extracellular vesicles, which comprise exosomes and microvesicles. In this study, we investigate regenerative effects isolated microvesicles from ASCs evaluate mechanisms how ASC promote wound healing. Adipose cell-derived (ASC-MVs) were differential ultracentrifugation, stained PKH26, characterized electron...
The refractory diabetic wound has remained a worldwide challenge as one of the major health problems. impaired angiogenesis phase during healing partly contributes to pathological process. MicroRNA (miRNA) is an essential regulator gene expression in crucial biological processes and promising nucleic acid drug therapeutic fields wound. However, miRNA therapies have limitations due lacking effective delivery system. In present study, we found significant reduction miR-31-5p full-thickness...
Abstract Human adipose‐derived stem cells (ASCs) have a potential for the treatment of peripheral nerve injury. Recent studies demonstrated that can mediate therapeutic effect by secreting exosomes. We aimed to investigate human ASCs derived exosomes (ASC‐Exos) on regeneration in vitro and vivo. Our results showed after being internalized Schwann (SCs), ASC‐Exos significantly promoted SC proliferation, migration, myelination, secretion neurotrophic factors upregulating corresponding genes...
Rationale: Peripheral nerve injury is common in clinic, which leads to severe atrophy and dysfunction of the denervated muscles, but underlying mechanism not fully understood. Recent studies advanced causative role mitochondrial muscle atrophy, while upstream triggers remained unclear. Methods: In present study, Atrophy gastrocnemius tibialis anterior (TA) were evaluated mice sciatic transection model. Transmission electron microscopy (TEM) was then used observe microstructure atrophic...
Internal organs heal injuries with new connective tissue, but the cellular and molecular events of this process remain obscure. By tagging extracellular matrix around mesothelium lining in mouse peritoneum, liver cecum, here we show that preexisting was transferred across into wounds various injury models. Using proteomics, genetic lineage-tracing selective juxtaposed organs, found tissue origin for likely dictated scarring or regeneration healing tissue. Single-cell RNA sequencing chemical...
Oxidative damage is a critical cause of diabetic wounds. Exosomes from various stem cells could promote wound repair. Here, we investigated the potential mechanism by which exosomes adipose-derived (ADSC-EXOs) healing through modulation oxidative stress. We found that ADSC-EXOs proliferation, migration, and angiogenesis in keratinocytes, fibroblasts, endothelial cells. Furthermore, reduced reactive oxygen species (ROS) levels these protected them against hypoxic stress damage. Finally, local...
Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of inflammation, contraction scar formation1. Here we identify a multipotent fibroblast progenitor marked CD201 expression in the fascia, deepest connective layer skin. Using skin injury models mice, single-cell transcriptomics genetic lineage tracing, ablation gene deletion models, demonstrate that CD201+ progenitors control pace wound healing generating multiple specialized cell types, from...
Good clinical outcome after digital nerve repair is highly relevant for proper hand function and has a significant socioeconomic impact. However, level of evidence competing surgical techniques low. The aim to summarize compare the outcomes with different methods (end-to-end end-to-side coaptations, grafts, artificial conduit-, vein-, muscle, muscle-in-vein reconstructions, replantations) provide an aid choosing individual technique reconstruction create reference values standard...
Background: In a previous prospective study, the authors evaluated quality of life in patients undergoing aesthetic surgery. this survey, split up operative indication and analyzed life, self-esteem, emotional stability after abdominoplasty alone. Methods: Sixty-three participated study. The testing instrument consisted self-developed questionnaire to collect demographic socioeconomic data postoperative complication developed especially for abdominoplasties. addition, standardized...
All engineered bioartificial structures developed for tissue regeneration require oxygen and nutrients to establish proper physiological functions. Aiming improve vascularization during dermal regeneration, we combined the use of a collagen scaffold defined human mesenchymal cell (MC) line. This line, termed V54/2, exhibits typical morphologic immunohistochemical characteristics MC. V54/2 cells seeded in were able survive, proliferate, secrete significant amounts vascular endothelial growth...