A5101452587- Wound Healing and Treatments
- Extracellular vesicles in disease
- Burn Injury Management and Outcomes
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Diagnosis and Treatment of Venous Diseases
- Cancer-related molecular mechanisms research
- DNA and Nucleic Acid Chemistry
- Diabetic Foot Ulcer Assessment and Management
- Planarian Biology and Electrostimulation
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Histone Deacetylase Inhibitors Research
- Nanoplatforms for cancer theranostics
- Cancer therapeutics and mechanisms
- Biochemical and Molecular Research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Synthesis and Catalytic Reactions
Union Hospital
2022-2024
Huazhong University of Science and Technology
2022-2024
Central Hospital of Wuhan
2024
Chongqing University
2022
Wuhan Union Hospital
2022
Union Hospital
2022
Oxidative damage is a critical cause of diabetic wounds. Exosomes from various stem cells could promote wound repair. Here, we investigated the potential mechanism by which exosomes adipose-derived (ADSC-EXOs) healing through modulation oxidative stress. We found that ADSC-EXOs proliferation, migration, and angiogenesis in keratinocytes, fibroblasts, endothelial cells. Furthermore, reduced reactive oxygen species (ROS) levels these protected them against hypoxic stress damage. Finally, local...
Ischemic diseases caused by diabetes continue to pose a major health challenge and effective treatments are in high demand. Mesenchymal stem cells (MSCs) derived exosomes have aroused broad attention as cell-free treatment for ischemic diseases. However, the efficacy of from adipose-derived mesenchymal (ADSC-Exos) treating diabetic lower limb injury remains unclear.Exosomes were isolated ADSCs culture supernatants differential ultracentrifugation their effect on C2C12 HUVECs was assessed...
Non-healing trauma, with limited treatment options, remains a prevalent complication of diabetes mellitus. The underlying causes wherein include oxidative stress injury, bacterial infection, cellular dysfunction, and persistent inflammation. Acellular Dermal Matrix (ADM), wound dressing composed natural extracellular matrix abundant bioactive factors, has been successfully developed to treat various wounds, including burns diabetic ulcers. Protocatechualdehyde (PA) & trivalent iron ion...
Phenylbutyric acid (PBA) has been reported as a dual inhibitor of pyruvate dehydrogenase kinases (PDKs) and histone deacetylases (HDACs), exhibiting anticancer effects. However, the low membrane permeability poor cellular uptake limit its access to target organelle, resulting in weak potencies against intended targets. Herein, we report design identification novel 4-CF3-phenyl triphenylphosphonium-based PBA conjugate (53) with improved vitro vivo activities. Compound 53 exhibited an IC50...
Diabetic wound healing has become a public health issue that lacks effective treatment. We collected oral squamous cell carcinoma samples and paracancerous tissue extracted Ti-Exos for verification. In vitro assays revealed OSCC Ti-EVs could enhance the proliferation migration of endothelial cells, keratinocytes, fibroblasts in diabetic model. vivo also verified promote healing, demonstrated preliminary biosafety mice, have promise as therapeutic applications.
Abstract Small extracellular vesicles (sEVs) from adipose‐derived stem cells (ADSCs) have gained great attention and been widely used in cell‐free therapies for treating diabetic non‐healing wounds recent years. However, further clinical application of ADSC‐sEVs limited due to their unsolvable defects, including cumbersome extraction procedure, high cost, low yield, etc. Thus, we urgently need find one therapeutic reagent that could not only accelerate wound healing as but also overcome...
Angiogenesis is essential for diabetic wound healing. Endothelial progenitor cell-derived extracellular vesicles (EPC-EVs) are known to promote healing by enhancing angiogenesis, while the low yield and lack of effective targeting strategies limit their therapeutic efficacy. Here, biomimetic nanovesicles (NVs) prepared from EPC (EPC-NV) through an extrusion approach were reported, which functioned as EV mimetics deliver contents wound. Besides, cRGD peptide was coupled surface EPC-NV...
Abstract Diabetic wound, as a serious complication of diabetes mellitus (DM), leads to persistent infection, amputation and even death. Prolonged oxidative stress has been widely recognized the main cause diabetic wound is considered hopeful therapeutic target. In present study, Keap1/Nrf2 signaling was confirmed be activated in streptozotocin (STZ)-induced mice methylglyoxal (MGO)-treated human umbilical vein endothelial cells (HUVEC). Knockdown Keap1 by siRNA attenuated raised level,...