Chengcheng Li

ORCID: 0000-0002-9901-7691
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About
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Research Areas
  • Reconstructive Surgery and Microvascular Techniques
  • Breast Implant and Reconstruction
  • Body Contouring and Surgery
  • Renal Transplantation Outcomes and Treatments
  • Reconstructive Facial Surgery Techniques
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Wound Healing and Treatments
  • Ferroptosis and cancer prognosis
  • Mesenchymal stem cell research
  • Breast Cancer Treatment Studies
  • Pharmacogenetics and Drug Metabolism
  • Drug Transport and Resistance Mechanisms
  • Effects of Radiation Exposure
  • Pharmacological Effects and Toxicity Studies
  • Lung Cancer Treatments and Mutations
  • Biosensors and Analytical Detection
  • interferon and immune responses
  • Machine Learning in Healthcare
  • Cancer, Hypoxia, and Metabolism
  • SARS-CoV-2 and COVID-19 Research
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Cancer, Lipids, and Metabolism
  • Solar-Powered Water Purification Methods
  • RNA Research and Splicing
  • Electrospun Nanofibers in Biomedical Applications

Southern Medical University
2021-2025

Hainan University
2025

Donghua University
2025

Huazhong University of Science and Technology
2022-2024

Tianjin University
2020-2024

National Taipei University of Technology
2022-2024

Affiliated Hospital of Guizhou Medical University
2024

Union Hospital
2024

Guiyang Medical University
2024

Jinan University
2022-2024

Diabetic foot ulcer is a serious complication in diabetes patients, imposing physical and economic burden to patients the healthcare system as whole. Oxidative stress thought be key driver of pathogenesis such ulcers. However, no antioxidant drugs have received clinical approval date, underscoring need for further development medications. Hydrogels can applied directly wound site, wherein they function prevent infection maintain local moisture concentrations, addition serving reservoir...

10.1021/acsami.1c24569 article EN ACS Applied Materials & Interfaces 2022-03-17

Abstract Accelerating water evaporation is vital for processes like photosynthesis, dehydration, and desalination. Optimizing the pore structure interfacial properties of evaporative materials can reduce enthalpy increase efficiency. However, integrating interface with transport channels poses significant design challenges complicates low‐enthalpy analysis. To address these challenges, a hydrophilic nanovesicle gel developed hydrophobic mesoporous as an ideal spray. This spray effectively...

10.1002/adma.202419243 article EN Advanced Materials 2025-03-11

Iron overload, caused by hereditary hemochromatosis or repeated blood transfusions in some diseases, such as beta thalassemia, bone marrow failure and myelodysplastic syndrome, can significantly induce injured (BM) function well parenchyma organ dysfunctions. However, the effect of iron overload its mechanism remain elusive. In this study, we investigated effects on hematopoietic stem progenitor cells (HSPCs) from a mouse model. Our results showed that markedly decreased ratio clonogenic...

10.1038/srep10181 article EN cc-by Scientific Reports 2015-05-13

Metals can be either toxic or essential to health, as they play different role in oxidative stress and metabolic homeostasis during the ageing process. Population-based biomonitoring have documented levels ranges concentrations among general population of 0–79 years age. In people aged 80 above, metals may risk profiles, thus need better studied. Our aim is investigate (arsenic, cadmium, lead mercury) (chromium, cobalt, molybdenum, manganese, nickel selenium) their diseases, nutritional...

10.1016/j.envint.2021.106717 article EN cc-by-nc-nd Environment International 2021-06-19

White matter injury (WMI) is an important cause of high disability after intracerebral haemorrhage (ICH). It widely accepted that reactive oxygen species (ROS) contributes to WMI, but there still no evidence-based treatment. Here, mitoquinone (MitoQ), a newly developed selective mitochondrial ROS scavenger, was used test its neuroprotective potential. The data showed MitoQ attenuated motor function deficits and motor-evoked potential (MEP) latency prolongation. Further research found blunted...

10.1155/2020/8285065 article EN cc-by Oxidative Medicine and Cellular Longevity 2020-01-06

Cardiovascular diseases have been identified as one of the top three causes death worldwide, with onset and deaths mostly due to heart failure (HF). In ICU, where patients HF are at increased risk consume significant medical resources, early accurate prediction time for high would enable them receive appropriate timely care. The data this study were obtained from MIMIC-III database, we collected vital signs tests 6699 patient during first 24 h their ICU admission. order predict mortality in...

10.3390/jcm11216460 article EN Journal of Clinical Medicine 2022-10-31

Exposure to a moderate high dose of ionizing radiation (IR) not only causes acute syndrome but also induces long-term (LT) bone marrow (BM) injury. The latter effect IR is primarily attributed the induction hematopoietic stem cell (HSC) senescence. Granulocyte colony-stimulating factor (G-CSF) treatment recommended be given victims soon after IR. However, clinical studies have shown that G-CSF used treat leukopenia induced by radiotherapy or chemotherapy in patients can cause sustained low...

10.1186/s13578-015-0057-3 article EN cc-by Cell & Bioscience 2015-11-25

Glycogen, a randomly branched glucose polymer, provides energy storage in organisms. It forms small β particles which animals bind to form composite α particles, give better release. Simulations imply particle size is controlled only by activities and sizes of glycogen biosynthetic enzymes polymer chains. Thus, storing more requires forming are expected sometimes particles. No have been reported bacteria, but the extraction techniques might caused degradation. Using milder on Escherichia...

10.1021/acs.biomac.9b00586 article EN publisher-specific-oa Biomacromolecules 2019-06-04

Intracerebral haemorrhage (ICH) is a devastating disease that characterized by high morbidity and mortality. ICH has an annual incidence of 10–30/100 000 people accounts for approximately 10% to 30% all types stroke. mostly occurs at the basal ganglia, which rich in nerve fibres; thus, hemiplegia quite common patients with partial sensory disturbance ectopic blindness. In clinic, those symptoms are considered originate from white matter injury area, but exact mechanisms unknown, currently,...

10.3389/fnmol.2019.00098 article EN cc-by Frontiers in Molecular Neuroscience 2019-04-17

As one of the most common liver diseases, nonalcoholic fatty disease (NAFLD) affects almost one-quarter world’s population. Although prevalence NAFLD is continuously rising, effective medical treatments are still inadequate. Radix Polygoni Multiflori (RPM) a traditional Chinese herbal medicine. processed product RPM, prepared (PRPM) has been reported to have antioxidant and anti-inflammatory effects. This study investigated whether PRPM treatment could significantly improve NAFLD. We used...

10.18632/aging.205485 article EN cc-by Aging 2024-01-26

Introduction: The renin-angiotensin system (RAS) has been considered to play an important role in the regulation of blood pressure. This study aimed investigate correlation between RAS gene polymorphisms and essential hypertension (EH) Chinese Yi ethnic group. Materials methods: A total 244 EH subjects 185 normotensive individuals from group were genotyped for AGT M235T (rs699), AT1R A1166C (rs5186), ACE I/D (rs4340) G2350A (rs4343) by polymerase chain reaction (PCR)-restriction fragment...

10.1177/1470320315598697 article EN cc-by-nc Journal of the Renin-Angiotensin-Aldosterone System 2015-08-17

To report the testing signal of an immunochromatographic assay for on-site quantitative detection, a portable and user-friendly smartphone-based biosensing platform is developed in this study. This innovative system composed ambient light sensor inherent smartphone reader 3D-printed handhold device, tool capable directly interpreting carbon nanoparticle (CNP)-conjugated strips. showcase capability, immunochromatography (SPICS) device were successfully used CNP strips rapid detection early...

10.1039/d4lc00484a article EN Lab on a Chip 2024-01-01

Abstract The cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigation, cis‐acting elements that control of CYP3As remain uncharacterized. Using chromatin conformation capture (4C assays), we detected reciprocal interaction a distal regulatory region (DRR) CYP3A4 promoter. DRR colocalizes variety enhancer marks...

10.1111/cts.13398 article EN cc-by-nc-nd Clinical and Translational Science 2022-09-01

Purpose: The aim of this study was to analyze the effects various genetic polymorphisms and clinical factors on tacrolimus (TAC) concentration in convalescence period (CP) stabilization (SP) post-liver transplantation. Patients & methods: A total 13 SNPs were genotyped 97 Chinese liver transplant recipients. Associations between TAC trough blood concentration/dose ratio (C0/D) analyzed using different models both CP SP. Results: Only five significantly associated with log CP, none showed a...

10.2217/pgs-2022-0180 article EN Pharmacogenomics 2023-03-01
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