A5115602070- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Fungal Biology and Applications
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Acute Myeloid Leukemia Research
- Viral gastroenteritis research and epidemiology
- Peptidase Inhibition and Analysis
- Drug Transport and Resistance Mechanisms
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Renal and related cancers
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Insect-Plant Interactions and Control
- Histone Deacetylase Inhibitors Research
- Connective tissue disorders research
- Monoclonal and Polyclonal Antibodies Research
Soochow University
2013-2025
First Affiliated Hospital of Soochow University
2024-2025
Nanjing University of Finance and Economics
2022-2025
Beth Israel Deaconess Medical Center
2025
Zhengzhou University
2010-2025
West China Hospital of Sichuan University
2015-2025
Capital Medical University
2015-2025
Sichuan University
2011-2025
First Affiliated Hospital of Zhengzhou University
2016-2025
Chengdu Normal University
2022-2025
Although aerobic glycolysis (the Warburg effect) is a hallmark of cancer, key questions, including when, how, and why cancer cells become highly glycolytic, remain less clear. For largely unknown regulatory mechanism, rate-limiting glycolytic enzyme pyruvate kinase M2 (PKM2) isoform exclusively expressed in embryonic, proliferating, tumor cells, plays an essential role metabolism growth. Because the receptor tyrosine kinase/PI3K/AKT/mammalian target rapamycin (RTK/PI3K/AKT/mTOR) signaling...
Abstract Colorectal cancer (CRC) is a common human gastrointestinal cancer, and recent studies indicate that circular RNA (circRNA) may regulate development. In this study, we assess the role of circRNA specifically in colorectal cancer. Our quantitative PCR assays demonstrate an upregulation has_circ_0020397 downregulation miR‐138 CRC cells, as well negative correlation between these two. Using dual‐luciferase reporter assay, show evidence miR‐138‐binding sites on hsa_circ_0020397,...
Antibody-drug conjugates (ADC) are emerging as clinically effective therapy. We hypothesized that cancers treated with ADCs would acquire resistance mechanisms unique to immunoconjugate therapy and changing ADC components may overcome resistance. Breast cancer cell lines were exposed multiple cycles of anti-Her2 trastuzumab-maytansinoid (TM-ADC) at IC80 concentrations followed by recovery. The resistant cells, 361-TM JIMT1-TM, characterized cytotoxicity, proteomic, transcriptional, other...
Lagoviruses belong to the Caliciviridae family. They were first recognized as highly pathogenic viruses of European rabbit (Oryctolagus cuniculus) and brown hare (Lepus europaeus) that emerged in 1970–1980s, namely, haemorrhagic disease virus (RHDV) syndrome (EBHSV), according host species from which they had been detected. However, diversity lagoviruses has recently expanded include new related with varying pathogenicity, geographic distribution ranges. Together frequent recombination...
Higher plants acquire iron (Fe) from the rhizosphere through two strategies. Strategy II, employed by graminaceous plants, involves secretion of phytosiderophores (e.g. deoxymugineic acid in rice [Oryza sativa]) roots to solubilize Fe(III) soil. In addition taking up Fe form Fe(III)-phytosiderophore, also possesses strategy I-like system that may absorb Fe(II) directly. Through mutant screening, we isolated a could not grow with Fe(III)-citrate as sole source, but was able when Fe(II)-EDTA...
Neuregulin 1 (NRG1) is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 multiple isoforms are generated by usage of different promoters alternative splicing single gene. However, little known about isoform composition profile, whether it changes during or the underlying mechanisms. We found each six types distinct expression pattern brain at ages, resulting change composition. In both human rat, most dominant III II, followed...
Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that has demonstrated clinical benefit for patients with HER2+ metastatic breast cancer; however, its activity limited by inherent or acquired drug resistance. The molecular mechanisms drive resistance to T-DM1, especially in tumors, are not well understood. We used cell lines develop models of T-DM1 using a cyclical dosing schema which cells received "on-off" routine until T-DM1-resistant population was generated. N87...
Up to now, the gingiva-derived mesenchymal stem cells (GMSCs) as a new postnatal have been isolated and characterized with multipotential differentiation capabilities in vitro. However, vivo efficacy of utilizing GMSCs bone regeneration remains obscure. First all, we identified canonical MSCs human gingival tissue, which possessed homogenous immunophenotype (CD34−CD45−CD29+CD105+CD90+ STRO-1+) had tri-lineage potential (osteoblasts, adipocytes, chondrocytes). Next, examined these tissue...
Abstract Mammalian target of rapamycin (mTOR) is a major downstream effector the receptor tyrosine kinase (RTK)–phosphoinositide 3-kinase (PI3K)–v-akt murine thymoma viral oncogene homologue 1 (AKT) signaling pathway. Although this network frequently altered in cancer, underlying mechanisms that cause tumorigenesis as result activated mTOR remain largely unknown. We report here expression lactate dehydrogenase B (LDHB), critical enzymatic activator glycolysis, was upregulated an...
miR‐20a is an important member of the miR‐17–92 cluster, and its real function in cervical cancer cells unknown. Our study demonstrated that was upregulated tissues. Overexpression cancer‐derived cell lines, HeLa C‐33A, enhanced long‐term cellular proliferation, migration invasion, whereas inhibition suppressed those functions. We also confirmed oncogenic TNKS2 directly by miR‐20a. Furthermore, suppression expression could inhibit colony formation, invasion cells. Therefore, we concluded can...
Novel selective histone deacetylase 6 (HDAC6) inhibitors using the quinazoline as cap were designed, synthesized, and evaluated for HDAC enzymatic assays. N-Hydroxy-4-(2-methoxy-5-(methyl(2-methylquinazolin-4-yl)amino)phenoxy)butanamide, 23bb, was most potent inhibitor HDAC6 with an IC50 of 17 nM showed 25-fold 200-fold selectivity relative to HDAC1 HDAC8, respectively. In vitro, 23bb presented low nanomolar antiproliferative effects against panel cancer cell lines. Western blot analysis...
Super-enhancers are large clusters of transcriptional enhancers regarded as having essential roles in driving the expression genes that control cell identity during development and tumorigenesis. The construction a genome-wide super-enhancer database is urgently needed to better understand super-enhancer-directed gene regulation for given biology process. Here, we present specifically designed web-accessible database, Super-Enhancer Archive (SEA, http://sea.edbc.org). SEA focuses on...
Epitopes of phospholipase A2 receptor (PLA2R), the target antigen in idiopathic membranous nephropathy (iMN), must be presented by HLA–encoded MHC class II molecules to stimulate autoantibody production. A genome–wide association study identified risk alleles at HLA and PLA2R loci, with top variant rs2187668 within HLA-DQA1 showing a effect greater than that rs4664308 PLA2R1. How affect epitope presentation iMN is unknown. Here, we genotyped 261 patients 599 healthy controls HLA-DRB1,...
Dynamic change of mitochondrial morphology and distribution along neuronal branches are essential for neural circuitry formation synaptic efficacy. However, the underlying mechanism remains elusive. We show here that Pink1 knockout (KO) mice display defective dendritic spine maturation, reduced axonal vesicles, abnormal connection, attenuated long-term potentiation (LTP). Drp1 activation via S616 phosphorylation rescues deficits maturation in KO neurons. Notably, harboring a knockin (KI)...
Background and AimsTRIM21 is a ubiquitin E3 ligase that implicated in numerous biological processes including immune response, cell metabolism, redox homeostasis, cancer development. We recently reported TRIM21 can negatively regulate the p62-Keap1-Nrf2 antioxidant pathway by ubiquitylating p62 prevents its oligomerization protein sequestration function. As homeostasis plays pivotal role many cancers liver cancer, we sought to determine of hepatocarcinogenesis.MethodsWe examined correlation...
The rapid and accurate acquisition of nitrogen, phosphorus potassium nutrient contents in grape leaves is critical for improving yields quality industrial development. In this study, crop growth was non-destructively monitored based on unmanned aerial vehicle (UAV) remote sensing technology. Three irrigation levels (W1, W2 W3) four fertilization (F3, F2, F1 F0) were set drip treatments adopted a complete block design. A correlation analysis conducted using UAV multispectral image data...
Stress hyperglycemia is strongly associated with poor clinical outcomes in patients acute coronary syndrome (ACS). Recently, the stress ratio (SHR) has been proposed to represent relative hyperglycemia. Studies regarding relationship between SHR and mortality artery disease (CAD) are limited. This study aimed clarify association in-hospital CAD. A total of 19,929 CAD who were hospitalized Beijing Hospital enrolled this study. Patients an estimated glomerular filtration rate < 30 ml/min,...