A5054893410- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Health disparities and outcomes
- Nutritional Studies and Diet
- Sleep and related disorders
- Fatty Acid Research and Health
- Air Quality and Health Impacts
- Pesticide Exposure and Toxicity
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Gestational Diabetes Research and Management
- Health Systems, Economic Evaluations, Quality of Life
- Cancer-related molecular mechanisms research
- Cardiovascular Health and Disease Prevention
- Alcohol Consumption and Health Effects
- Pregnancy and preeclampsia studies
- Hormonal Regulation and Hypertension
- Cardiac Health and Mental Health
- Heavy Metal Exposure and Toxicity
- Neuroendocrine regulation and behavior
- Lipoproteins and Cardiovascular Health
- Autophagy in Disease and Therapy
Shanghai Jiao Tong University
2018-2025
Ruijin Hospital
2019-2025
National Health and Family Planning Commission
2024
Zhengzhou University
2020-2024
Peking Union Medical College Hospital
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Jinan Central Hospital
2024
Shandong First Medical University
2024
The First People's Hospital of Changde
2024
Central South University
2024
Abstract Mammalian target of rapamycin (mTOR) is a major downstream effector the receptor tyrosine kinase (RTK)–phosphoinositide 3-kinase (PI3K)–v-akt murine thymoma viral oncogene homologue 1 (AKT) signaling pathway. Although this network frequently altered in cancer, underlying mechanisms that cause tumorigenesis as result activated mTOR remain largely unknown. We report here expression lactate dehydrogenase B (LDHB), critical enzymatic activator glycolysis, was upregulated an...
OBJECTIVE Comprehensive assessment of serum lipidomic aberrations before type 2 diabetes mellitus (T2DM) onset has remained lacking in Han Chinese. We evaluated changes lipid coregulation antecedent to T2DM and identified novel predictors for individuals with normal glucose regulation (NGR). RESEARCH DESIGN AND METHODS In the discovery study, we tested 667 baseline lipids subjects incident propensity score–matched control (n = 200) from a prospective cohort comprising 3,821 Chinese adults...
Purpose: Atherosclerotic cardiovascular disease may share the risk factors for low bone mineral density (BMD), one of which is dyslipidemia. The association between serum cholesterol and BMD remains controversial. Thus, correlation lipids in women was explored current study. Materials Methods: This cross-sectional study included 1116 Chinese female participants. Serum samples were collected to evaluate total (TC), low-density lipoprotein (LDL-C), high-density (HDL-C), other laboratory...
In humans and animals, exposure to changes in internal or external environments causes acute stress, which sleep enhances neurochemical, neuroendocrine, sympathetic activities. Repeated stress responses play an essential role the pathogenesis of psychiatric diseases disorders. However, underlying mechanism anxiety disorders response is not well established. current study, effects restraint (RS) on sleep-wake cycles mice were investigated. We found that after RS, showed anxiety-like behavior...
Background The triglyceride glucose (TyG) index has been associated with an increased risk in breast cancer. However, this association remains unclear among the Chinese population. This study aimed to investigate whether TyG is of prevalent cancer women. Methods cross-sectional included 142,184 women from REACTION (Risk Evaluation Cancers Diabetic Individuals: A Longitudinal) Study, which recruited adults aged 40 years or older 25 centers across mainland China between 2011 and 2012. was...
To elucidate the regulatory mechanism of circRNAs in diabetic retinopathy. Next-generation sequencing (NGS) was employed to identify that are abnormally expressed endothelial progenitor cells (EPCs) under hyperglycemia (HG) conditions. The and predicted targets this circRNA were also studied via bioinformatics analysis, luciferase reporter assays, angiogenic differentiation experiments, flow cytometry, RT-qPCR. Circ-astrotactin 1 (circ-Astn1) expression decreased EPCs HG conditions,...
Exposure to particulate matter has been associated with diseases of the respiratory and cardiovascular systems. Owing dense vasculature kidney, it also identified as a PM2.5 target organ. A potential contributor PM2.5-mediated damage may be promotion inflammation. The essential oil 2-undecanone (2-methyl nonyl ketone) is an H. cordata isolate, shown possess diverse pharmacologic effects, including anti-inflammatory properties. In this study we explored ability protect against PM2.5-induced...
Abstract Background The study aimed to characterize the prevalence of alcohol consumption and further investigate relationship between type 2 diabetes mellitus (T2DM). Methods We studied 39,259 participants aged 18 79 years Henan Rural Cohort study. associations T2DM were examined using logistic regression models restricted cubic spline. Results For men, abstinence was associated with an increased risk (1.491(1.265, 1.758)), whereas current drinkers not (1.03(0.91, 1.15)). Further analysis...
Epidemiological evidence regarding the effect of omega-3 polyunsaturated fatty acid (PUFA) supplementation on inflammatory bowel disease (IBD) is conflicting. Additionally, little exists effects specific components IBD risk. We applied two-sample Mendelian randomization (MR) to disentangle PUFAs (including total omega-3, α-linolenic acid, eicosapentaenoic (EPA), or docosahexaenoic (DHA)) risk IBD, Crohn's (CD) and ulcerative colitis (UC). Our findings indicated that genetically predicted...
The prevalence of heart failure (HF) subtypes, which are classified by left ventricular ejection fraction (LVEF), demonstrate significant sex differences. Here, we perform sex-stratified genome-wide association studies (GWASs) on LVEF and transcriptome-wide Mendelian randomization (MR) LVEF, all-cause HF, HF with reduced (HFrEF), preserved (HFpEF). GWASs identified three sex-specific loci that were exclusively detected in the GWASs. Three drug target genes show sex-differential effects...
Fish oil (FO), a mixture of omega-3 fatty acids mainly comprising docosahexaenoic acid (DHA) and eicosapentaenoic (EPA), has been recommended for patients with type 2 diabetes (T2D) hypertriglyceridemia. However, its effects on lipidomic profiles gut microbiota the factors influencing triglyceride (TG) reduction remain unclear.
Observational studies and conventional Mendelian randomization (MR) showed inconclusive evidence to support the association between omega-3 fatty acids type 2 diabetes. We aim evaluate causal effect of on diabetes mellitus (T2DM), distinct intermediate phenotypes linking two.Two-sample MR was performed using genetic instruments derived from a recent genome-wide study (GWAS) (N = 114,999) UK Biobank outcome data obtained large-scale T2DM GWAS (62,892 cases 596,424 controls) in European...
This study examined whether resting heart rate (RHR) was associated with metabolic syndrome (MetS) and the 10-year predicted risk of cardiovascular disease in a Chinese population.The associations RHR MetS atherosclerotic diseases (ASCVD) cross-sectional conducted Shanghai, China (n = 9486).Compared individuals lowest quintile (≤71 b.p.m.), those highest (≥91 b.p.m.) had higher prevalence (21.2% vs 32.6%, respectively; P < 0.001). Logistic regression analyses showed that...
Abstract Epidemiological studies suggested an association between omega-3 fatty acids and cognitive function. However, the causal role of acid desaturase ( FADS ) gene, which play a key in regulating biosynthesis, on function is unclear. Hence, we used two-sample Mendelian randomization (MR) to estimate gene-specific effect N = 114,999) 300,486). Tissue- cell type-specific effects FADS1 / FADS2 expression were estimated using brain tissue cis-expression quantitative trait loci (cis-eQTL)...
Background: To investigate the prevalence of thyroid nodules among medical staff and health check-up population in a Level-A hospital (Primary-level hospital) Jinan City analyze its influencing factors. Methods: A total 5812 cases from two groups were screened. t -test χ 2 tests used to differences nodules. Multivariate Logistic regression analysis was explore Results: The average age (36.20± 9.11) years old, 48.5%. healthcare (57.89± 12.51) rate 63.9%, with statistical significance between...