A5100338206- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Plant Molecular Biology Research
- High-Energy Particle Collisions Research
- Photosynthetic Processes and Mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Plant Reproductive Biology
- Advanced Fluorescence Microscopy Techniques
- Cell Image Analysis Techniques
- Plant biochemistry and biosynthesis
- Genetics and Plant Breeding
- Genomics and Phylogenetic Studies
- Plant Gene Expression Analysis
- Computational Physics and Python Applications
- Natural product bioactivities and synthesis
- Cellular Automata and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Crystal structures of chemical compounds
- Wheat and Barley Genetics and Pathology
- Plant Stress Responses and Tolerance
- Neural Networks and Applications
- Plant tissue culture and regeneration
- Phytochemicals and Antioxidant Activities
Affiliated Hospital of Southwest Medical University
2025
Chinese Academy of Sciences
2001-2024
Sichuan Agricultural University
2017-2024
Chengdu University
2024
Chengdu University of Traditional Chinese Medicine
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Xiangtan University
2024
Nanjing Medical University
2022-2024
Beijing Institute of Nanoenergy and Nanosystems
2024
University of Chinese Academy of Sciences
2014-2024
Accurate psychiatric diagnosis and assessment are vital for effective treatment, yet current methods often rely on subjective observations during time-constrained clinical interviews. This study explores the use of Large Language Models (LLMs) to automate distinction diagnostic categories symptoms from psychiatrist-patient dialogues, aiming offer interpretable insights automatic diagnosis. We analyzed audio recordings 1160 interviews, primarily involving patients with depressive disorder...
A sudden cooling in the early spring or late autumn negatively impacts plant growth and development. Although a number of studies have characterized role transcription factors (TFs) R2R3-myeloblastosis (R2R3-MYB) response to biotic abiotic stress, growth, primary specific metabolisms, much less is known about their Rosa multiflora under chilling stress. In present study, RmMYB108 , which encodes nuclear-localized R2R3-MYB TF with self-activation activity, was identified based on earlier...
Pea (Pisum sativum L.) is an annual cool-season legume crop. Owing to its role in sustainable agriculture as both a rotation and cash crop, global market expanding increased production urgently needed. For technical regulatory reasons, neither conventional nor transgenic breeding techniques can keep pace with the demand for production. In answer this challenge, CRISPR/Cas9 genome editing technology has been gaining traction plant biology crop recent years. However, there are currently no...
Abstract Platycodon grandiflorus (Jacq.) A. DC, known for its saponin content, can potentially prevent and treat cerebrovascular diseases COVID-19. Triterpenoid biosynthesis in plants is enhanced by methyl jasmonate (MeJA) application. However, the underlying molecular mechanisms of MeJA-induced remain unknown P. grandiflorus. In current study, exogenous application 100 μmol/l MeJA was identified to be optimal promoting accumulation. RNA sequencing analysis demonstrated PgbHLH28 gene as a...
Resin embedding is a well-established technique to prepare biological specimens for microscopic imaging. However, it not compatible with modern green-fluorescent protein (GFP) fluorescent-labelling because significantly quenches the fluorescence of GFP and its variants. Previous empirical optimization efforts are good thin tissue but successful on macroscopic blocks as quenching mechanism remains uncertain. Here we show most quenched molecules structurally preserved denatured after routine...
Parsing diverse nerve cells into biological types is necessary for understanding neural circuit organization. Morphology an intuitive criterion neuronal classification and a proxy of connectivity, but morphological diversity variability often preclude resolving the granularity neuron types. Combining genetic labeling with high-resolution, large-volume light microscopy, we established single anatomy platform that resolves, registers, quantifies complete morphologies in mouse brain. We...
A thorough neuroanatomical study of the brain architecture is crucial for understanding its cellular compositions, connections, and working mechanisms. However, fine- multiscale features neuron structures make it challenging microscopic imaging, as requires high contrast throughput simultaneously. Here, we propose chemical sectioning fluorescence tomography (CSFT) to solve this problem. By chemically switching OFF/ON fluorescent state labeled proteins (FPs), light only top layer thin...
Sugar–sugar glycosyltransferases play important roles in constructing complex and bioactive saponins. Here, we characterized a series of UDP-glycosyltransferases responsible for biosynthesizing the branched sugar chain steroidal saponins from widely known medicinal plant Paris polyphylla var. yunnanensis. Among them, 2′-O-rhamnosyltransferase three 6′-O-glucosyltrasferases catalyzed cascade glycosylation to produce diglycosides triglycosides, respectively. These showed astonishing substrate...
Multivalent-ion batteries have garnered significant attention due to their high energy density, low cost, and superior safety. Calcium-ion (CIBs) are regarded as the next-generation storage systems for abundant natural resources bivalent characteristics. However, absence of high-performance anode materials poses a obstacle progress battery technology. Two-dimensional (2D) Dirac excellent conductivity active sites, rendering them promising candidates materials. A novel 2D material known...
Eucommia ulmoides Oliver (EuO) is a traditional Chinese herb with effects on repairing disorders of liver lipid metabolism and enhancing immunity in mice. In this study, the EuO immune enhancement protection M. salmoides were tested by adding 3% to high-starch diet evaluated histopathology, enzymology, flow cytometry, molecular biology. The results showed that high starch promoted hepatocytes apoptosis, damaged liver, led impaired function. However, integrality was recoverd, innate response...
Background The triglyceride glucose (TyG) index has been associated with an increased risk in breast cancer. However, this association remains unclear among the Chinese population. This study aimed to investigate whether TyG is of prevalent cancer women. Methods cross-sectional included 142,184 women from REACTION (Risk Evaluation Cancers Diabetic Individuals: A Longitudinal) Study, which recruited adults aged 40 years or older 25 centers across mainland China between 2011 and 2012. was...
Abstract Background Previous research has established a correlation between immune cells and an increased likelihood of Chronic pancreatitis (CP). However, studies investigating the causal relationship remain limited. Methods This study utilized publicly available genome-wide association (GWAS) databases conducted two-sample Mendelian randomization (MR) analysis to examine relationships (CRs) among 731 cells, 1,400 metabolites, CP. Mediation MR was also performed assess whether metabolites...
This paper studies fast fusion of dense retrieval and sparse lexical retrieval, proposes a cluster-based selective method called CluSD guided by retrieval. takes lightweight approach exploits the overlap results embedding clusters in two-stage selection process with an LSTM model to quickly identify relevant while incurring limited extra memory space overhead. triggers partial performs block disk I/O if needed. evaluates compares it several baselines for searching in-memory on-disk MS MARCO...
SUMMARY The plant pollen wall protects the male gametophyte from various biotic and abiotic stresses. formation of a unique structure elaborate exine pattern is well‐organized process, which needs coordination between reproductive cells neighboring somatic cells. However, molecular mechanisms underlying this process remain largely unknown. Here, we report rice male‐sterile mutant ( l94 ) that exhibits defective patterning abnormal tapetal cell development. MutMap knockout analyses...
The enzymatic browning induced in amla juice due to the high activity of polyphenol oxidase (PPO) and peroxidase (POD) is one critical issues faced by industry. present study assessed suitability non-thermal, high-intensity ultrasound (US) on inactivation PPO POD fresh Indian Gooseberry juice. Ultrasonic waves, using a 6 mm titanium alloy probe were irradiated at maximum power 455 W frequency 20 kHz. subsequent effects biochemical attributes studied response surface methodology. Inactivation...
Rapid and high-resolution imaging of large tissues is essential in biological research, like brain neuron connectivity research cancer margins imaging. Here a novel stage-scanning confocal microscopy was developed for rapid tissues. Line scanning methods strip strategy were used to increase the speed. The scientific CMOS as line detector sub-array mode optical sectioning ability can be easily adjusted by changing number detectors according different samples. Fluorescent beads showed...