Ruizhi Zheng
A5064581554- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Gut microbiota and health
- Hypothalamic control of reproductive hormones
- Cardiovascular Health and Disease Prevention
- Diabetes Management and Research
- Bioinformatics and Genomic Networks
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Sexual Differentiation and Disorders
- Heart Rate Variability and Autonomic Control
- Diet, Metabolism, and Disease
- Fatty Acid Research and Health
- Cardiovascular Disease and Adiposity
- Gastroesophageal reflux and treatments
- Cardiac Health and Mental Health
Ruijin Hospital
2020-2025
Shanghai Jiao Tong University
2020-2025
Fujian Provincial Hospital
2025
Fujian Medical University
2025
Fuzhou University
2025
National Health and Family Planning Commission
2022-2024
National Clinical Research
2024
Third Affiliated Hospital of Sun Yat-sen University
2023
Sun Yat-sen University
2023
State Key Laboratory of Medical Genomics
2023
We investigated the causal relationships between gut microbiota (GM), stroke, and potential metabolite mediators using Mendelian randomization (MR).We leveraged summary statistics of GM (n=18,340 in MiBioGen consortium), blood metabolites (n=115,078 UK Biobank), stroke (cases n=60,176 controls n=1,310,725 Global Biobank Meta-Analysis Initiative) from largest genome-wide association studies to date. performed bidirectional MR analyses explore two mediation analyses, two-step multivariable MR,...
BackgroundEffective targets for systolic blood-pressure control in patients with type 2 diabetes are unclear.MethodsWe enrolled 50 years of age or older diabetes, elevated blood pressure, and an increased risk cardiovascular disease at 145 clinical sites across China. Patients were randomly assigned to receive intensive treatment that targeted a pressure less than 120 mm Hg standard 140 up 5 years. The primary outcome was composite nonfatal stroke, myocardial infarction, hospitalization...
Although previous studies suggest that amino acids (AAs) and microbiota-related metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain unclear among normoglycemic populations. We test 28 serum AAs 22 MRMs in 3,414 subjects incident matched controls from China Cardiometabolic Disease Cancer Cohort (4C) Study. In fully adjusted logistic regression models, per SD increment of branched-chain AAs, aromatic asparagine, alanine, glutamic acid, homoserine,...
Background The triglyceride glucose (TyG) index has been associated with an increased risk in breast cancer. However, this association remains unclear among the Chinese population. This study aimed to investigate whether TyG is of prevalent cancer women. Methods cross-sectional included 142,184 women from REACTION (Risk Evaluation Cancers Diabetic Individuals: A Longitudinal) Study, which recruited adults aged 40 years or older 25 centers across mainland China between 2011 and 2012. was...
OBJECTIVE Comprehensive assessment of serum bile acids (BAs) aberrations before diabetes onset remains inconclusive. We examined the association BA profile and coregulation with risk developing type 2 mellitus (T2DM) among normoglycemic Chinese adults. RESEARCH DESIGN AND METHODS tested 23 species in subjects incident (n = 1,707) control matched by propensity score (including age, sex, BMI, fasting glucose) from China Cardiometabolic Disease Cancer Cohort (4C) Study, which was composed...
Abstract Context Observational studies indicated obesity and glutamatergic dysfunction as potential risk factors of depression, reported disturbance glutamine metabolism in obese state. However, it remains unclear whether the interrelationships between obesity, glutamine, depression are causal. Objective We conducted 2-sample bidirectional mendelian randomization (MR) analyses to explore causalities circulating levels, specific depressive symptoms, major disorder (MDD), body mass index...
Prediabetes and its pathophysiology remain important issues. We aimed to examine the cluster characteristics of prediabetes explore their associations with developing diabetes complications based on 12 variables representing body fat, glycemic measures, pancreatic β cell function, insulin resistance, blood lipids, liver enzymes. A total 55,777 individuals from China Cardiometabolic Disease Cancer Cohort (4C) were classified at baseline into six clusters. During a median 3.1 years follow-up,...
Abstract Background Gut microbiota imbalances have been suggested as a contributing factor to atrial fibrillation (AF), but the causal relationship is not fully understood. Objectives To explore relationships between gut and AF using Mendelian randomization (MR) analysis. Methods Summary statistics were from genome-wide association studies (GWAS) of 207 microbial taxa (5 phyla, 10 classes, 13 orders, 26 families, 48 genera, 105 species) (the Dutch Microbiome Project) two large meta-GWASs AF....
Importance With the widespread use of anti–SARS-CoV-2 drugs, accumulating data have revealed potential viral load rebound after treatment. Objective To compare COVID-19 a standard 5-day course antiviral treatment with VV116 vs nirmatrelvir-ritonavir. Design, Setting, and Participants This is single-center, investigator-blinded, randomized clinical trial conducted in Shanghai, China. Adult patients mild-to-moderate within 5 days SARS-CoV-2 infection were enrolled between December 20, 2022,...
OBJECTIVE We aimed to examine the effects of a 5:2 diet (2 days per week energy restriction by formula diet) or an exercise high-intensity interval training and resistance training) intervention compared with routine lifestyle education (control) on glycemic control cardiometabolic health among adults overweight/obesity type 2 diabetes. RESEARCH DESIGN AND METHODS This two-center, open-label, three-arm, parallel-group, randomized controlled trial recruited 326 participants diabetes them into...
ObjectivesThe objectives of this study were to determine species distribution and in vitro antifungal susceptibility Candida isolates identified the multicentre China-SCAN invasive infection (ICI) intensive care units (ICUs) across China.
Background Previous studies reported that early‐life exposure to undernutrition is associated with the risk of diabetes mellitus and metabolic syndrome in adulthood, but association cardiovascular disease ( CVD ) later life remains unclear. The current study aimed investigate whether Chinese famine early . Methods Results We used data from REACTION (Risk Evaluation Cancers Diabetic Individuals: A Longitudinal Study), which recruited a total 259 657 community‐dwelling adults aged 40 years or...
OBJECTIVE Type 1 and type 2 diabetes are associated with gut dysbiosis. However, the relationship between microbiota latent autoimmune in adults (LADA), sharing clinical metabolic features classic diabetes, remains unclear. Here, we used a multiomics approach to identify characteristics of profiles patients LADA. RESEARCH DESIGN AND METHODS This age- sex-matched case-control study included 30 LADA, 29 31 healthy individuals. The were identified through 16S rRNA gene, fecal serum metabolites...