A5030346569- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Immune Response and Inflammation
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- Immune cells in cancer
- Mesenchymal stem cell research
- Nosocomial Infections in ICU
- COVID-19 Clinical Research Studies
- Neuroscience of respiration and sleep
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Immunotherapy and Biomarkers
- Acute Kidney Injury Research
- Immune Cell Function and Interaction
- Renal function and acid-base balance
- Airway Management and Intubation Techniques
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Immunotherapy and Immune Responses
- Anesthesia and Neurotoxicity Research
Zhongda Hospital Southeast University
2016-2025
China-Japan Friendship Hospital
2024
First Affiliated Hospital of Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
Sun Yat-sen University
2023
Sun Yat-sen University Cancer Center
2023
Second Military Medical University
2023
Eastern Hepatobiliary Surgery Hospital
2023
Southeast University
2010-2022
tion (SARI) caused by 2019 novel coronavirus (SARS-CoV-2), began to spread from Wuhan all of China [1, 2], and indeed the world.As Feb 10, 2020, there are more than 40,000 confirmed cases > 1000 deaths in China.
The COVID-19 outbreak has led to 80,409 diagnosed cases and 3,012 deaths in mainland China based on the data released March 4, 2020. Approximately 3.2% of patients with required intubation invasive ventilation at some point disease course. Providing best practices regarding for an overwhelming number amid enhanced risk cross-infection is a daunting undertaking. authors presented experience caring critically ill Wuhan. It extremely important follow strict self-protection precautions. Timely,...
Acute kidney injury is common in critically ill patients, many of whom receive renal-replacement therapy. However, the most effective timing for initiation such therapy remains uncertain.
The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) European Society Intensive Care Medicine (ESICM). scope this CPG limited adult patients and non-pharmacological respiratory support strategies across different aspects acute distress syndrome (ARDS), including ARDS due coronavirus disease 2019 (COVID-19). These were formulated by an international panel experts, one methodologist patients’ representatives on behalf ESICM. review was conducted in compliance...
Another interesting finding of this case series is that hypertension was the most common chronic comorbidity among patients who died.A previous 2020 1 also reported a higher rate with COVID-19 were admitted to intensive care units than not units.However, usually an independent risk factor associated mortality in sepsis. 5According study from earlier year, 6 severe acute respiratory syndrome coronavirus 2 infects lungs through angiotensin-converting enzyme II receptor.Further research needed...
We performed a national cross-sectional survey to determine the epidemiologic characteristics of patients with sepsis in ICU China.A cross-section study.Forty-four hospitals mainland China from December 1, 2015, January 31, 2016.All septic diagnosed according sepsis-1 criteria admitted participating ICU.None.We recorded demographic, physiologic, and microbiological data follow-up for 90 days or death, if sooner. The frequency 90-day mortality rate were computed, relationship gross domestic...
Since publication of the 2012 Berlin definition acute respiratory distress syndrome (ARDS), several developments have supported need for an expansion definition, including use high-flow nasal oxygen, pulse oximetry in place arterial blood gases, ultrasound chest imaging, and applicability resource-limited settings.
An uncontrolled inflammatory response is a critical pathophysiological feature of sepsis. Mesenchymal stem cells (MSCs) induce macrophage phenotype polarization and reduce inflammation in MSC-secreted transforming growth factor beta (TGF-β) participated the immune modulatory function MSCs. However, underlying mechanism TGF-β was not fully elucidated regulation M2-like polarization.The paracrine effects MSCs on were studied using co-culture protocol with LPS-stimulated RAW264.7 cells/mouse...
Abstract Background Excessive respiratory muscle effort during mechanical ventilation may cause patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no non-invasive methods to reliably detect elevated transpulmonary driving pressure assisted ventilation. We hypothesized that the swing in airway generated by under when is briefly occluded (Δ P occ ) could be used as a highly feasible technique screen for these conditions. Methods Respiratory ( mus ), dynamic...
Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis.
Noroviruses are enterically transmitted and a frequent cause of gastroenteritis, affecting 23 million people annually in the United States. We describe norovirus outbreak its control tertiary care hospital during February-May 2004.Patients health workers met case definition if they had new onset vomiting and/or diarrhea period. Selected stool samples were tested for RNA. also determined costs, including estimated lost revenue associated with unit closures, sick leave, cleaning expenses.We...
Abstract Background Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) via paracrine hepatocyte growth factor (HGF) and induce the differentiation of dendritic (DCs) into tolerogenic (DCregs) participate in immune response. However, whether MSCs production DCregs by secreting HGF early ALI remains unclear. We observed that protective effect mouse bone marrow-derived against lipopolysaccharide (LPS)-induced was achieved inducing mature DCs (mDCs) differentiate...
Summary Background COVID-19 pandemic has developed rapidly and the ability to stratify most vulnerable patients is vital. However, routinely used severity scoring systems are often low on diagnosis, even in non-survivors. Therefore, clinical prediction models for mortality urgently required. Methods We internally validated a multivariable logistic regression model predict inpatient positive using data collected retrospectively from Tongji Hospital, Wuhan (299 patients). External validation...
Extensively drug-resistant (XDR) Gram-negative bacilli (GNB) are defined as bacterial isolates susceptible to two or fewer antimicrobial categories. XDR-GNB mainly occur in Enterobacteriaceae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. The prevalence of is on the rise China other countries, it poses a major public health threat result lack adequate therapeutic options. A group Chinese clinical experts, microbiologists pharmacologists came together...
Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS). Objectives: We hypothesized that lung microenvironment was the main determinant beneficial versus detrimental effects MSCs during ARDS. Methods: Lung proteome profiled three models injury induced by acid instillation and/or mechanical ventilation mice. Human gene glutathione peroxidase-1 delivered before MSC administration; or carrying...