A5061502473- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cytomegalovirus and herpesvirus research
- Inflammation biomarkers and pathways
- Nosocomial Infections in ICU
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- interferon and immune responses
- Thyroid Cancer Diagnosis and Treatment
- Mesenchymal stem cell research
- Airway Management and Intubation Techniques
- Legionella and Acanthamoeba research
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
First Affiliated Hospital of Guangzhou Medical University
2016-2025
State Key Laboratory of Respiratory Disease
2016-2025
Guangzhou Medical University
2016-2025
Shanxi Medical University
2020-2024
Second Hospital of Shanxi Medical University
2020-2024
GTx (United States)
2024
Gaozhou People's Hospital
2021
Health First
2020
National Clinical Research
2020
Gynecologic Oncology Group
2019
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for 2019 (COVID-19) pneumonia. Little known about kinetics, tissue distribution, cross-reactivity, and neutralization antibody response in patients with COVID-19. Two groups of RT-PCR-confirmed COVID-19 were enrolled this study: 12 severely ill intensive care units who needed mechanical ventilation 11 mildly isolation wards. Serial clinical samples collected laboratory detection. Results showed that most had...
Since early February 2021, the causative agent of COVID-19, SARS-CoV-2, has infected over 104 million people with more than 2 deaths according to official reports. The key understanding biology and virus-host interactions SARS-CoV-2 requires knowledge mutation evolution this virus at both inter- intra-host levels. However, despite quite a few polymorphic sites identified among populations, variant spectra their evolutionary dynamics remain mostly unknown.Using high-throughput sequencing...
Abstract AKT signaling is constitutively activated in various cancers, due large part to loss-of-function the PTEN and PHLPP phosphatases that act as tumor suppressor genes. However, widely non–small cell lung cancers (NSCLC) where genetic alterations or genes are rare, suggesting an undefined mechanism(s) for their suppression. In this study, we report upregulation of oncomir microRNA (miR)-205 multiple subtypes NSCLC, which directly represses PHLPP2 expression activates both AKT/FOXO3a...
Abstract Cancer chemoresistance and metastasis are tightly associated features. However, whether they share common molecular mechanisms thus can be targeted with one strategy remain unclear in non-small cell lung cancer (NSCLC). Here, we report that high levels of microRNA-128-3p (miR-128-3p) is key to concomitant development residual NSCLC cells having survived repeated chemotherapy correlates chemoresistance, aggressiveness poor prognosis patients. Mechanistically, miR-128-3p induces...
Abstract Deeper mechanistic understanding of lung adenocarcinoma (non–small cell carcinoma, or NSCLC), a leading cause cancer-related deaths overall, may lead to more effective therapeutic strategies. In analyzing NSCLC clinical specimens and lines, we discovered uniform decrease in miR-186 (MIR186) expression comparison with normal tissue epithelial lines. correlated patient survival, median overall survival time 63.0 21.5 months cases exhibiting high low levels miR-186, respectively....
Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS). Objectives: We hypothesized that lung microenvironment was the main determinant beneficial versus detrimental effects MSCs during ARDS. Methods: Lung proteome profiled three models injury induced by acid instillation and/or mechanical ventilation mice. Human gene glutathione peroxidase-1 delivered before MSC administration; or carrying...
The aim of this study was to investigate the mechanism through which Sphingosine kinase-1 (SPHK1) exerts its anti-apoptosis activity in glioma cancer cells. We here report that dysregulation SPHK1 alters sensitivity apoptosis both vitro and vivo. Further mechanistic examined expression Bcl-2 family members, including Bcl-2, Mcl-1, Bax Bim, SPHK1-overexpressing cells revealed only pro-apoptotic Bim downregulated by SPHK1. Moreover, transcriptional level also altered next confirmed correlation...
Metastasis-associated in colon cancer-1 (MACC1) was first identified as a transcriptional activator for proto-oncogene c-MET expression, and its overexpression is frequently associated with metastatic progression multiply tumor types. In the present study, we analyzed time expression of MACC1 breast cancer correlation clinicopathologic features, including metastasis patient survival.MACC1 protein two cohorts clinicopathologically characterized using immunohistochemistry. Statistical analysis...
Abstract Background A significant proportion of septic patients with acute lung injury (ALI) are recognized late due to the absence an efficient diagnostic test, leading postponed treatments and consequently higher mortality. Identifying biomarkers may improve screening identify at high risk ALI earlier provide potential effective therapeutic drugs. Machine learning represents a powerful approach for making sense complex gene expression data find robust biomarkers. Methods The datasets were...
Abstract Background In December 2019, human infection with a novel coronavirus, known as SARS-CoV-2, was identified in Wuhan, China. The mortality of critical illness high Wuhan. Information about critically ill patients SARS-CoV-2 outside Wuhan is scarce. We aimed to provide the clinical features, treatment, and prognosis Guangdong Province. Methods this multi-centered, retrospective, observational study, we enrolled pneumonia who were admitted intensive care unit (ICU) Demographic data,...
Objective Alterations in microRNA (miRNA) expression have been described thyroid tumors, suggesting a role for miRNAs carcinogenesis. BRAF V600E is the most frequently identified genetic alteration papillary carcinoma (PTC). We investigated link between status and of PTC analyzed associations these factors with clinicopathological characteristics. Design methods Prospective study patients who underwent surgery October 8, 2008 November 1, 2010. was determined by mutant allele-specific...
Background Immunosuppression is common even in the early stage of severe sepsis. Interleukin-10 (IL-10) secretion and lymphocyte exhaustion are main features sepsis-induced immunosuppression. However, relationship between IL-10 still unclear. We investigated if IL-10/lymphocyte ratio (IL10LCR) were associated with mortality septic patients. Methods Adult patients sepsis admitted to ICU First Affiliated Hospital Guangzhou Medical University identified from October 2012 August 2013. Within 24...
Thyroid cancer is the most common malignant endocrine tumor and classified into papillary thyroid (PTC), follicular (FTC) anaplastic (ATC), which have substantially different characteristics. Insulin-like growth factor binding protein 7 (IGFBP7) has recently been recognized as a suppressor in many types. However, expression pattern of IGFBP7 its biological function various types carcinoma remain poorly understood. We found that levels FTC ATC tissues were significantly lower or even absent...
Background: Neutrophil-to-lymphocyte count ratio (NLCR) has been shown as a feasible parameter associated with outcomes of tumor patients and an accessible predictor bacteremia. However, only handful research shed the light on association between NLCR septic patients. This study is aimed to evaluate all-cause mortality in population adult
Cytomegalovirus (CMV) reactivation is associated with adverse prognoses of critically ill patients. However, the epidemiology and predictors CMV in immunocompetent patients receiving mechanical ventilation (MV) are not clear. The aim this study was to investigate requiring MV.A single-center, prospective observational (conducted from June 30, 2017 July 01, 2018) a follow-up 90 days (September 29, that included 71 CMV-seropositive MV at 37-bed university hospital general intensive care unit...