A5101900614- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Influenza Virus Research Studies
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Data-Driven Disease Surveillance
- Dengue and Mosquito Control Research
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Zoonotic diseases and public health
- Disaster Response and Management
- Vaccine Coverage and Hesitancy
- Malaria Research and Control
- COVID-19 and healthcare impacts
- Virus-based gene therapy research
- Virology and Viral Diseases
- Immune responses and vaccinations
- COVID-19 and Mental Health
- COVID-19 Pandemic Impacts
Tianjin Centers for Disease Control and Prevention
2024
Guangdong Provincial Center for Disease Control and Prevention
2013-2022
University of Hong Kong
2018-2020
Guangzhou Center for Disease Control and Prevention
2015-2020
Poultry Research Institute
2018
Centers for Disease Control and Prevention
2017
National Institute for Viral Disease Control and Prevention
2016
University of Cambridge
2014
University of Virginia
2010
Fo Guang Shan
2001
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for 2019 (COVID-19) pneumonia. Little known about kinetics, tissue distribution, cross-reactivity, and neutralization antibody response in patients with COVID-19. Two groups of RT-PCR-confirmed COVID-19 were enrolled this study: 12 severely ill intensive care units who needed mechanical ventilation 11 mildly isolation wards. Serial clinical samples collected laboratory detection. Results showed that most had...
ABSTRACT Rationale Several studies have estimated basic production number of novel coronavirus pneumonia (NCP). However, the time-varying transmission dynamics NCP during outbreak remain unclear. Objectives We aimed to estimate and across China, compared them with SARS. Methods Data on cases by February 7, 2020 were collected from epidemiological investigations or official websites. severe acute respiratory syndrome (SARS) in Guangdong Province, Beijing Hong Kong 2002-2003 also obtained....
The role of fecal aerosols in the transmission severe acute respiratory syndrome coronavirus 2 has been suspected.
This study aimed to estimate the attack rates, and identify risk factors of COVID-19 infection. Based on a retrospective cohort study, we investigated 11,580 contacts cases in Guangdong Province from 10 January 15 March 2020. All were tested by RT-PCR detect their infection SARS-COV-2. Attack rates characteristics calculated. Logistic regression was used for COVID-19. A total 515 identified be infected with Compared young adults aged 20-29 years, higher children (RR: 2.59, 95%CI: 1.79-3.76),...
Since early February 2021, the causative agent of COVID-19, SARS-CoV-2, has infected over 104 million people with more than 2 deaths according to official reports. The key understanding biology and virus-host interactions SARS-CoV-2 requires knowledge mutation evolution this virus at both inter- intra-host levels. However, despite quite a few polymorphic sites identified among populations, variant spectra their evolutionary dynamics remain mostly unknown.Using high-throughput sequencing...
Significance Using extensive data on dengue fever and mosquito density, we demonstrate that local weather conditions, through their impact the variation of abundance, are a driver dynamics in China. We believe this mechanism can be applied to explain other places as well. furthermore conjecture our integrative approach would applicable vector-borne diseases, such Zika, malaria, chikungunya.
Dengue cases have been reported each year for the past 25 years in Guangdong Province, China with a recorded historical peak 2014. This study aims to describe epidemiological characteristics of this large outbreak order better understand its epidemic factors and inform control strategies.Data clinically diagnosed laboratory-confirmed dengue fever 2014 were extracted from Notifiable Infectious Disease Reporting System. We analyzed incidence imported indigenous terms population, temporal...
We compared the detection frequency of avian influenza H7 subtypes at live poultry markets in Guangdong Province, China, before and after introduction a bivalent H5/H7 vaccine poultry. The was associated with 92% reduction positivity rates among 98% human H7N9 cases.
Background. In recent decades, the GII.4 norovirus genotype has predominated in epidemics worldwide and been associated with an increased rate of evolutionary change. 2014, a novel GII.17 variant emerged persisted, causing large outbreaks gastroenteritis China sporadic infections globally. The origin, evolution, transmission history this new are largely unknown. Methods. We generated 103 full capsid 8 whole-genome sequences strains collected between August 2013 November 2015 Guangdong,...
China implemented containment measures to stop SARS-CoV-2 transmission in response the COVID-19 epidemic. After first epidemic wave, we conducted population-based serological surveys determine extent of infection, risk factors for and neutralization antibody levels assess real infections random sampled population.We used a multistage, stratified cluster sampling strategy conduct three areas - Wuhan, Hubei Province outside six provinces selected on incidence strategy. Participants were...
Background An explosive outbreak of dengue fever occurred in Guangdong Province, China 2014. A community-based integrated intervention was applied to control this the capital city Guangzhou, where epidemic mainly caused by imported cases. Methodology/Principal Findings We used a time series generalized additive model based on meteorological factors assess effectiveness intervention. The results showed that there significant reduction mosquito density following intervention, and 70.47% (95%...
An unusual prevalence of recombinant GII.2 noroviruses (GII.P16-GII.2) in Guangdong, China, at the end 2016 caused a sharp increase outbreaks acute gastroenteritis. This event was another non-GII.4 epidemic that emerged after GII.17 viruses 2014 and 2015 warrants global surveillance.
To provide an increased understanding of avian influenza A(H7N9) activity in live-poultry market space and time hence improve H7N9 epidemic control, ongoing environmental sampling program multiple markets across Guangdong, China was conducted during March 2013-June 2014.A total 625 throughout 21 prefecture areas took part the study. A 10 sites for were identified to represent 4 different poultry-related areas. At least samples collected from each every month. The real RT-PCR performed detect...
Influenza A(H7N9) virus emerged in eastern China February 2013 and continues to circulate this region, but its ecology is poorly understood. In April 2013, the Guangdong Provincial Center for Disease Control Prevention (CDC) implemented environmental human syndromic surveillance virus. Environmental samples from poultry markets 21 city CDCs (n=8,942) respiratory persons with influenza-like illness or pneumonia (n=32,342) were tested; viruses isolated 6 16 patients sequenced. Sequence...
Abstract Confirmation of an imported case infection with Middle East respiratory syndrome coronavirus in China triggered intensive contact tracing and mandatory monitoring. Using a hotline surveillance video footage was effective for all 110 identified contacts. Contact monitoring detected no secondary transmission China.
Risk assessment of the intra-city spatio-temporal spreading COVID-19 is important for providing location-based precise intervention measures, especially when epidemic occurred in densely populated and high mobile public places. The individual-based simulation has been proven to be an effective method risk assessment. However, acquisition individual-level mobility data limited. This study used publicly available datasets approximate dynamic travel flows by a gravity model. On this basis,...