A5018315525- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- COVID-19 Pandemic Impacts
- Sphingolipid Metabolism and Signaling
- Respiratory viral infections research
- RNA modifications and cancer
- COVID-19 impact on air quality
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- Zoonotic diseases and public health
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Air Quality and Health Impacts
- Mosquito-borne diseases and control
- Plant-Microbe Interactions and Immunity
- Metabolomics and Mass Spectrometry Studies
- Viral Infections and Outbreaks Research
- Ginseng Biological Effects and Applications
- Phagocytosis and Immune Regulation
- Botany and Plant Ecology Studies
Gansu Agricultural University
2023-2025
Renmin Hospital of Wuhan University
2020-2025
Wuhan University
2020-2025
University of Oslo
2017-2025
Nanjing Medical University
2023-2025
Liaoning University
2024-2025
Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application
2025
Nanjing University
2025
Lanzhou University
2022-2024
First Hospital of Lanzhou University
2022-2024
Estimation of the prevalence and contagiousness undocumented novel coronavirus [severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)] infections is critical for understanding overall pandemic potential this disease. Here, we use observations reported infection within China, in conjunction with mobility data, a networked dynamic metapopulation model, Bayesian inference, to infer epidemiological characteristics associated SARS-CoV-2, including fraction their contagiousness. We estimate...
Non-small-cell lung cancer (NSCLC) is the leading cause of death. Early detection NSCLC will improve its outcome. The current techniques for early are either invasive or have low accuracy. Molecular analyses clinical specimens present promising diagnostic approaches. Non-coding RNAs (ncRNAs) play an important role in tumorigenesis and could be developed as biomarkers cancer. Here we aimed to develop small nucleolar (snoRNAs), a common class ncRNAs, detection. study comprised three phases:...
Making a definitive preoperative diagnosis of solitary pulmonary nodules (SPNs) found by CT has been clinical challenge. We previously demonstrated that microRNAs (miRNAs) could be used as biomarkers for lung cancer diagnosis. Here we investigate whether plasma are useful in identifying among individuals with CT-detected SPNs.By using quantitative reverse transcriptase PCR analysis, first determine expressions five miRNAs training set 32 patients malignant SPNs, 33 subjects benign and 29...
Abstract Background Estimation of the fraction and contagiousness undocumented novel coronavirus (COVID-19) infections is critical for understanding overall prevalence pandemic potential this disease. Many mild are typically not reported and, depending on their contagiousness, may support stealth transmission spread documented infection. Methods Here we use observations infection within China in conjunction with mobility data, a networked dynamic metapopulation model Bayesian inference, to...
Significance Using extensive data on dengue fever and mosquito density, we demonstrate that local weather conditions, through their impact the variation of abundance, are a driver dynamics in China. We believe this mechanism can be applied to explain other places as well. furthermore conjecture our integrative approach would applicable vector-borne diseases, such Zika, malaria, chikungunya.
Recent reports have showed that a proportion of patients with Coronavirus Disease 2019 (COVID-19) presented elevated leukocyte count. Clinical data about these is scarce. We aimed to evaluate the clinical findings COVID-19 who increased at admission. retrospectively collected on 52 count admission from 619 confirmed had pneumonia abnormal features chest CT scan in Renmin Hospital Wuhan University Wuhan, China, February 3 March 3, 2020. The mean age was 64.7 (SD 11.4) years, 32 (61.5%) were...
Emerging infectious diseases are one of the greatest public health challenges. Approximately three-quarters these animal origin. These include classical zoonoses maintained in humans only via transmission from other vertebrates (e.g., rabies) and those initiated by a successful one-off zoonotic event (host-switch) conjunction with efficient human-to-human H1N1 influenza). Here, we provide systematic review, meta-analysis spatial risk modeling, to identify major characteristics past epidemics...
Abstract A functional genomic approach integrating microarray and proteomic analyses done in our laboratory has identified 14-3-3ζ as a putative oncogene whose activation was common driven by its amplification lung adenocarcinomas. is believed to function cell signaling, cycle control, apoptotic death. Following initial finding, here, we analyzed expression tumor tissues obtained from 205 patients with various histologic stage non–small cancers (NSCLC) using immunohistochemistry then...
Abstract Purpose: Analysis of molecular genetic markers in biological fluids has been proposed as a powerful tool for cancer diagnosis. We have characterized detail the signatures primary non–small cell lung cancer, which provided potential diagnostic biomarkers cancer. The aim this study was to determine whether changes can be used sputum specimen early detection Experimental Design: Genetic aberrations genes HYAL2, FHIT, and SFTPC were evaluated paired tumors samples from 38 patients with...
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has been characterized unprecedented rates of spatio-temporal spread. Here, we summarize main events in pandemic's timeline and evaluate what learnt public health community. We also discuss implications for future policy and, specifically, practice epidemic control. critically analyze this ongoing contrast it with 2002–2003 SARS outbreak. identify specific areas (e.g., pathogen identification initial reporting) wherein...
Fusarium solani is a pathogenic fungus that causes significant harm, leading to crop yield reduction, fruit quality postharvest decay, and other diseases. This study used potato glycoside alkaloids (PGA) as inhibitors investigate their effects on the mitochondrial structure tricarboxylic acid (TCA) cycle pathway of F. . The results showed PGA could inhibit colony growth (54.49%), resulting in disappearance membrane loss contents. significantly decreased activities aconitase (ACO), isocitrate...
Clethodim is a chiral herbicide with two enantiomers. The herbicidal activity of (-)-clethodim 1.3-2.0-fold that (+)-clethodim, but the absolute configurations have not been clarified. In this study, enantiomers 1 and 2 resolved from racemate by preparative HPLC equipped Chiralpak IA column were confirmed as R-(-)-clethodim S-(+)-clethodim, respectively. Both showed significant stereoselectivity in vivo. AUC0-72h was 4.50 4.90 times S-(+)-clethodim plasma after intragastric intravenous...
Mycoplasma pneumoniae (M pneumoniae, MP) is a common pathogen causing respiratory tract infections, particularly in children. In 2023, resurgence of MP epidemics was observed Wuhan, Hubei Province, China. This study aims to examine the epidemiological trends and clinical characteristics infections among children Wuhan from 2018 2024, providing valuable scientific evidence guide local prevention strategies. From January 1, 2018, June 30, samples were collected under 14 years with Acute...
Fusarium solani is a widely distributed pathogenic fungus that can cause soil borne diseases in various plants and also one of the main bacteria Lycium barbarum root rot. This study employed tandem mass labeling (TMT) quantitative proteomics technology to investigate antifungal mechanism potato glycoside alkaloids (PGA) against . We elucidated PGA from perspective mitochondrial proteome molecular biology. Furthermore, we identified annotated differentially expressed proteins (DEP) F. under...
To understand infectious disease dynamics, we need to the inextricably intertwined nature of ecology and evolution pathogens hosts. Epidemiological dynamics many diseases have highlighted importance considering demographics societies in which they spread, particularly with respect age structure. In addition, waves recent COVID-19 pandemic driven by variant replacements at an unprecedented speed show that it is vital consider evolutionary aspects. The classic trade-off theory virulence...
To investigate the genomic aberrations that are involved in lung tumorigenesis and therefore may be developed as biomarkers for cancer diagnosis, we characterized copy number changes associated with individual genes 14 tumors from patients primary non small cell (NSCLC). Six squamous carcinomas (SQCAs) eight adenocarcinomas (ADCAs) were examined by high-resolution comparative hybridization (CGH) analysis of cDNA microarray. The SQCAs ADCAs shared common frequency distributions recurrent...