A5006025957- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Mosquito-borne diseases and control
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Drug-Induced Hepatotoxicity and Protection
- SARS-CoV-2 and COVID-19 Research
- Pain Mechanisms and Treatments
- Lung Cancer Diagnosis and Treatment
- COVID-19 epidemiological studies
- Long-Term Effects of COVID-19
- Vector-borne infectious diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Malaria Research and Control
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- Radiomics and Machine Learning in Medical Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Disease and Transplantation
- Metabolomics and Mass Spectrometry Studies
- Cancer Cells and Metastasis
- Acute Myocardial Infarction Research
- Pharmacogenetics and Drug Metabolism
Beijing YouAn Hospital
2010-2025
Capital Medical University
2015-2025
Xuzhou Medical College
2024-2025
Australian Regenerative Medicine Institute
2025
Quality Research
2025
Monash University
2020-2025
Jinzhou Medical University
2025
Shanghai University
2025
Beijing Ditan Hospital
2024-2025
Ankang City Central Hospital
2024
Introduction The treatment response to neoadjuvant immunochemotherapy varies among patients with potentially resectable non-small cell lung cancers (NSCLC) and may have severe immune-related adverse effects. We are currently unable accurately predict therapeutic response. aimed develop a radiomics-based nomogram major pathological (MPR) of NSCLC using pretreatment computed tomography (CT) images clinical characteristics. Methods A total 89 eligible participants were included randomly divided...
The comorbidity of chronic pain and depression poses tremendous challenges for the treatment either one because they exacerbate each other with unknown mechanisms. As posterior insular cortex (PIC) integrates multiple somatosensory emotional information is implicated in or depression, we hypothesize that PIC its projections may contribute to pathophysiology comorbid depression. We show neurons were readily activated by mechanical, thermal, aversive, stressful appetitive stimulation naive...
The treatment of COVID-19 in the post-transplant individuals is challenging, primarily due to drug-drug interaction between nirmatrelvir/ritonavir and tacrolimus. Deuremidevir hydrobromide tablets (VV116) an orally small molecule agents target SARS-CoV-2 RdRp inhibits viral replication. It may have a low likelihood interactions has potential provide new option. We described three cases renal transplant patients with concomitant impaired function who developed pneumonia were treated VV116....
Abstract Background The unprecedented outbreak of corona virus disease 2019 (COVID-19) infection in Wuhan City has caused global concern; the outflow population from was believed to be a main reason for rapid and large-scale spread disease, so government implemented city-closure measure prevent its transmission considering large amount travel before Chinese New Year. Methods Based on daily reported new cases population-movement data between 1 31 January, we examined effects geographical...
China has made substantial progress regarding COVID-19 control, as the local transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) almost been stopped. However, a serious natural disaster, flooding, unfortunately threatened lives and homes people in 27 provinces across central southern July, 2020. Starting on June 2, 2020, authorities issued alerts for heavy rainfall 41 consecutive days. The average precipitation areas along Yangtze River reached highest level since...
Neurons in the subthalamic nucleus (STN) become hyperactive following nerve injury and promote pain-related responses mice. Considering that anterior cingulate cortex (ACC) is involved pain emotion processing projects to STN, we hypothesize ACC neurons may contribute hyperactivity STN chronic pain. In present study, showed enhanced activity response noxious stimuli alterations emotional states became state established by spared of sciatic (SNI) naïve mice, were activated stimuli, but not...
Background. A recent study has reported that high circulating 25-hydroxyvitamin D [25(OH)D] is associated with low thyroid-stimulating hormone (TSH) levels, but only in younger individuals. The goal of the present was to explore relationship between vitamin status and TSH levels thyroid autoimmunity taken into consideration a population-based health survey middle-aged elderly Methods. total 1,424 Chinese adults, aged 41-78 years, were enrolled this cross-sectional study. Serum 25(OH)D, TSH,...
The aim of this study was to investigate the relationship serum uric acid (sUA) with residual β -cell function in type 2 diabetes. Oral glucose tolerance tests (OGTT) were performed on 1021 diabetes patients. ratio area under curve insulin during 0 30 min and 120 OGTT calculated as indices secretion function. products multiplied by Matsuda sensitivity index used disposition indices. After correlation multiple linear regression analysis, sUA significantly associated male, female, total groups...
Investigating the antipulmonary fibrosis effect of mangiferin from Mangifera indica and possible molecular mechanism.In vivo, bleomycin (BLM)-induced pulmonary experimental model was used for evaluating mangiferin. Histopathologic examination collagen deposition were investigated by HE Masson staining as well detecting content hydroxyproline. The expression transforming growth factor-β1 (TGF-β1), α-smooth muscle actin (α-SMA), TLR4 p-P65 in lung tissue analysed through immunofluorescence....
Pulmonary fibrosis is a progressive and irreversible fibrotic lung disorder with high mortality few treatment options. Recently, induced pluripotent stem (iPS) cells have been considered as an ideal resource for cell-based therapy. Although, earlier study demonstrated the therapeutic effect of iPS on pulmonary fibrosis, exact mechanisms remain obscure. The present investigated effects inflammatory responses, transforming growth factor (TGF)-β1 signaling pathway, epithelial to mesenchymal...
Anti-programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 predicting responses patients with anti-PD-1/PD-L1 is controversial. Some studies suggested that intra- and inter-tumoral heterogeneity expression might explain controversy. This study aimed analyze PD-L1, PD-L2, PD-1 as well CD8(+) T-cell density primary tumors lymph nodes from stage T1-4N+M0 adenocarcinoma...
To investigate the presence of vimentin expression in CTCs and its clinical relevance patients with advanced lung cancer.Peripheral blood was obtained from 61 treatment-naive cancer. Subtraction enrichment immunostaining-fluorescence situ hybridization (SE-iFISH) platform applied to identify, enumerate characterize based on cell size, aneuploidy chromosome 8 (Chr8) expression. Quantification analysis were performed before chemotherapy administration after two cycles therapy.Before treatment,...
Abstract The outbreak of pneumonia caused by a novel coronavirus (2019-nCoV) in Wuhan City China obtained global concern, the population outflow from has contributed to spatial expansion other parts China. We examined effects on 2019-nCoV transmission provinces and cities China, as well impacts city closure Wuhan. observed significantly positive association between movement number cases. Further analysis revealed that if policy was implemented two days earlier, 1420 (95% CI: 1059, 1833)...
Gypenoside (GP) is the major effective component of Gynostemma pentaphyllum and has been shown to encompass a variety pharmacological activities. In this study, we investigated whether GP able protect cardiomyocytes against injury myocardial ischemia-reperfusion (I/R) by using in vitro oxygen-glucose deprivation-reoxygenation (OGD/R) H9c2 cell model vivo I/R rat model. We found that pre-treatment alleviated impairments on cardiac structure function injured rats. Moreover, with significantly...