A5022267524- Venous Thromboembolism Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Acute Ischemic Stroke Management
- Blood Coagulation and Thrombosis Mechanisms
- COVID-19 Clinical Research Studies
- Ultrasound in Clinical Applications
- Cardiac tumors and thrombi
- Vascular Anomalies and Treatments
- Diagnosis and Treatment of Venous Diseases
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Issues in Pregnancy
- COVID-19 and healthcare impacts
- Clinical practice guidelines implementation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Central Venous Catheters and Hemodialysis
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Circular RNAs in diseases
Capital Medical University
2015-2025
China-Japan Friendship Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Peking University
2019-2025
National Clinical Research
2015-2024
Academy of Medical Sciences
2020-2024
National Clinical Research Center for Digestive Diseases
2017-2024
First Affiliated Hospital of Zhengzhou University
2024
Hebei Medical University
2024
Third Hospital of Hebei Medical University
2024
Objective To evaluate pulmonary function and clinical symptoms in coronavirus disease 2019 (COVID-19) survivors within 3 months after hospital discharge, to identify risk factors associated with impaired lung function. Methods material COVID-19 patients were prospectively followed-up tests characteristics for following discharge from a Wuhan, China between January February 2020. Results 647 included. 87 (13%) presented weakness, 63 (10%) palpitations 56 (9%) dyspnoea. The prevalence of each...
Background There has not been sufficient evidence to support the Asians being less susceptible pulmonary embolism (PE) than other ethnicities, because prevalence of PE/deep venous thrombosis (DVT) in different racial and ethnic groups carefully studied until recently except Caucasians. To test hypothesis that Chinese population a lower risk for PE, this study comprehensively assessed hospital-based incidence case fatality rates PE during 1997–2008 China. Methods A registration patients with...
BackgroundLimited data exist on VTE risk and prophylaxis in Chinese inpatients. The Identification of Hospitalized Patients' Risk Profile for Venous Thromboembolism-2 (DissolVE-2), a nationwide, multicenter, cross-sectional study, was therefore designed to investigate prevalence risks evaluate implementation compliant with the latest guidelines (American College Chest Physicians [CHEST], 9th edition).MethodsAdults admitted (≥ 72 h) 60 urban, tertiary hospitals due acute medical conditions or...
Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but debilitating and life-threatening complication of acute embolism. Circular RNAs (circRNAs), presenting as covalently closed continuous loops, are RNA molecules with joined 3′- 5′-ends formed by back-splicing events. circRNAs may be significant biological to understand disease mechanisms identify biomarkers for diagnosis therapy. The aim this study was investigate the potential roles in CTEPH. Methods: Ten human...
Early identification and treatment of chronic thromboembolic pulmonary hypertension (CTEPH) are critical to prevent disease progression. We determined the incidence risk factors for CTEPH in patients with a first episode acute embolism (PE).In this study, consecutive first-episode PE were followed ≤5 years. Pulmonary (PH) was screened by echocardiography. Suspected cases evaluated right heart catheterization (RHC) angiography (PA). If invasive procedures not permitted, PH diagnosed systolic...
Pulmonary embolism (PE) has not been accounted for as a cause of death contributing to cause-specific mortality in global reports.We analyzed PE-related by focusing on the latest year available each member state World Health Organization (WHO) database, which provides age-sex-specific aggregated data transmitted national authorities underlying death. deaths were defined International Classification Diseases, Tenth Revision codes acute PE or nonfatal manifestations venous thromboembolism...
Abstract Genome-wide association studies (GWAS) have identified numerous risk loci for venous thromboembolism (VTE), but it is challenging to decipher the underlying mechanisms. We employed an integrative analytical pipeline transform genetic associations identify novel plasma proteins VTE. Proteome-wide (PWAS) were determined by functional summary-based imputation leveraging data from a genome-wide analysis (14,429 VTE patients, 267,037 controls), blood proteomes (1348 cases), followed...
Determining novel biomarkers for early identification of chronic thromboembolic pulmonary hypertension (CTEPH) could improve patient outcomes. We used the isobaric tag relative and absolute quantitation approach to compare serum protein profiles between CTEPH patients controls. Bioinformatics analyses ELISA were also performed. identified three proteins including heparanase (HPSE), gelsolin (GSN), secreted acidic rich in cysteine (SPARC) had significant changes CTEPH. The receiver operating...
Early recognition and diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is crucial for improving prognosis reducing the disease burden. Established clinical practice guidelines describe interventions evaluation CTEPH, yet limited insight remains into variation barriers to care. The CTEPH global cross-sectional scientific survey (CLARITY) was developed gather insights current diagnosis, treatment, management identify unmet medical needs. This paper focuses on referral these...
Oxidative stress (OS) and reduced nitric oxide (NO) bioavailability contribute to the pathogenesis of pulmonary hypertension (PH). Whether there are associations between OS NO signaling biomarkers whether these associated with severity PH remain unclear. Blood samples were collected from 35 healthy controls patients arterial (PAH, n = 12) or chronic thromboembolic (CTEPH, 23). The mean artery pressure (mPAP) vascular resistance index (PVRI) measured by right heart catheterization. We...
Similar trends of management and in-hospital mortality acute pulmonary embolism (PE) have been reported in European American populations. However, these tendencies are not clear Asian countries. We retrospectively analysed the risk stratification, for patients with PE through a multicentre registry China (CURES). Adult symptomatic were included between 2009 2015. Trends disease diagnosis, treatment death hospital fully analysed. Risk stratification was classified by haemodynamic status...