A5017976270- Diabetes Management and Research
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Angiogenesis and VEGF in Cancer
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer Cells and Metastasis
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- MicroRNA in disease regulation
- Systemic Lupus Erythematosus Research
- Retinal Diseases and Treatments
- Traditional Chinese Medicine Analysis
- Medicinal plant effects and applications
- Pharmacology and Obesity Treatment
- Acute Myocardial Infarction Research
- Alcohol Consumption and Health Effects
- Sulfur Compounds in Biology
- Neonatal and fetal brain pathology
- Gestational Diabetes Research and Management
- Medicinal Plant Pharmacodynamics Research
- Atherosclerosis and Cardiovascular Diseases
- Cancer Research and Treatments
- Fibroblast Growth Factor Research
- Microbial Metabolism and Applications
Henan University Huaihe Hospital and Huaihe Clinical Institute
2012-2024
Henan University
2023
Diabetic nephropathy (DN) is the leading cause of end-stage renal failure, contributing to severe morbidity and mortality in diabetic patients. Berberine (BBR) has been well characterized exert renoprotective effects DN progression. However, action mechanism BBR remains be fully understood.The rat model was generated by intraperitoneal injection streptozotocin (STZ, 65 mg/kg body weight) while 30 mM high glucose (HG)-treated podocytes were used as an vitro model. The fasting blood level...
Nonalcoholic fatty liver disease (NAFLD) is the most common in world. Hydrogen sulfide (H2S) plays an important role physiology and pathophysiology of liver. However, whether exogenous H2S could mitigate hepatic steatosis mice remains unclear. The aim this study to evaluate effects on liver.C57BL/6 were fed with either a high-fat diet (HFD) or normal fat (NFD) for 16 weeks. After 12 weeks feeding, HFD-fed injected one time per day NaHS saline followed 4 weeks.Compared NFD, HFD induce...
BackgroundLimited data exist on VTE risk and prophylaxis in Chinese inpatients. The Identification of Hospitalized Patients' Risk Profile for Venous Thromboembolism-2 (DissolVE-2), a nationwide, multicenter, cross-sectional study, was therefore designed to investigate prevalence risks evaluate implementation compliant with the latest guidelines (American College Chest Physicians [CHEST], 9th edition).MethodsAdults admitted (≥ 72 h) 60 urban, tertiary hospitals due acute medical conditions or...
Abstract Aims/hypothesis The aim of this study was to assess the efficacy and safety oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes inadequately controlled metformin treatment. Methods Peptide Innovation for Early Diabetes Treatment (PIONEER) 12 trial randomised, double-dummy, active-controlled, parallel-group, Phase IIIa conducted over 26 weeks at 90 sites across China region (including mainland China, Taiwan Hong Kong) five other countries....
Abstract Aims To evaluate the efficacy and safety of iGlarLixi compared with iGlar in Chinese adults type 2 diabetes advancing therapy from basal insulin ± oral antihyperglycaemic drugs. Materials methods LixiLan‐L‐CN (NCT03798080) was a 30‐week randomized, active‐controlled, open‐label, parallel‐group, multicentre study. Participants were randomized 1:1 to or iGlar. The primary objective show superiority over glycated haemoglobin (HbA1c) change baseline Week 30. Results In total, 426...
Aims: Obesity is characterized as a chronic state of low-grade inflammation with progressive immune cell infiltration into adipose tissue. Adipose tissue macrophages play critical role in the establishment inflammatory states and metabolic dysfunctions. Inonotus ( I .) sanghuang its extract polyphenols exhibit anti-carcinogenesis, anti-inflammatory, anti-oxidant activities. However, action I. obesity-related has not been reported. The aim this study was to explore anti-inflammatory from...
Glucokinase variant-induced maturity-onset diabetes of the young (GCK-MODY) exhibits unique clinical features mild fasting hyperglycemia. However, formal studies its glucose excursion pattern in daily life comparison with those or without other types are lacking. We conducted a case-control study including 25 patients GCK-MODY, A1C-matched, drug-naive type 2 (T2DM), and age-, BMI-, sex-matched subjects normal tolerance (NGT). All wore flash monitoring (FGM) sensors for weeks, readings were...
To determine the safety of a higher starting dose basal insulin in overweight/obese patients with type 2 diabetes (T2D).This 16-week, randomized, multicentre, open-label trial enrolled adults T2D (body mass index 25-40 kg/m2 ) and suboptimal glycaemic control (glycated haemoglobin [HbA1c] 7.5-11.0% [58-97 mmol/mol] fasting plasma glucose [FPG] >9.0 mmol/L) two to three oral anti-hyperglycaemic drugs at 51 centres China. Patients were randomized (1:1) (0.3 U/kg) or standard (0.2 glargine 100...
Treatment with basal insulin in Chinese populations is currently sub-optimal, delayed initiation of treatment and inadequate dose titration. Increasing the initial may be a practicable effective solution to problem A higher will helpful for patients achieve blood glucose target improve satisfaction compliance as well require fewer steps titrate. Considering that overweight obese usually doses because resistance, feasible type 2 diabetes. However, safety an important issue needing considered...
Objective: To investigate the effects of pirfenidone on orbital fibroblasts (OFs) from patients with thyroid-associated ophthalmopathy (TAO) and its underlying mechanisms. Methods: OFs TAO were isolated cultured in DMEM. Cells divided into four groups treated 0, 250, 500 1 000 μg/ml for 24, 48 or 72 hours, respectively. Cell proliferation was detected by tetramethyl azo salt (MTT) assay, cell viability determined trypan blue. Transforming growth factor (TGF) β1 mRNA level real-time...
Objective To investigate retinal nerve fiber layer (RNFL) thickness changes using fourier domain optical coherence tomography (OCT) in patients with diabetic peripheral neuropathy (DPN).Methods One hundred and twelve cases DPN diagnosed type 2 diabetes were included NDR group (61 cases) NPDR (51 cases).According the Clinical Scoring System (CSS),all divided into mild (41 cases),moderate (38 severe (33 cases).The control 48 but non-DPN NDR.The RNFL was measured OCT.Each subject had circular...
Objective To explore whether endothelial progenitor cells(EPCs)exerts therapeutic effects on rats with diabetic peripheral neuropathy(DPN). Methods Diabetes was induced by streptozotocin. Male SD were divided into normal control group(NC group), neuropathy group(DPN DPN+ saline group(DPN+ S and EPCs group. Sciatic nerve motor conduction velocity(MNCV)was measured a electromyography trigger potentiometer instrument. Pathological changes observed under optical microscope electron...
Objective To explore the relationship of levels adhesion molecules and cytokines with vascular disease in patients type 2 diabetes (T2DM).Methods Ninety-six T2DM were selected as case group divided into non-vascular (28 cases),micro-vascular (33 cases) major group(35 according to disease.Meanwhile,30 healthy persons control group.Serum serum soluble intercellular molecule-1 (ICAM-1),vascular cell (VCAM-1),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α) yon willebrand factor (vWF)...
<p> </p> <p>Glucokinase variant-induced maturity-onset diabetes of the young (GCK-MODY) exhibits unique clinical features mild fasting hyperglycaemia. However, formal studies its glucose excursion pattern in daily life comparison with those or without other types are lacking. We conducted a case-control study including 25 patients GCK-MODY, A1c-matched, drug naive type 2 (T2DM) and age-, BMI- sex-matched subjects normal tolerance (NGT). All wore flash monitoring (FGM)...
<p> </p> <p>Glucokinase variant-induced maturity-onset diabetes of the young (GCK-MODY) exhibits unique clinical features mild fasting hyperglycaemia. However, formal studies its glucose excursion pattern in daily life comparison with those or without other types are lacking. We conducted a case-control study including 25 patients GCK-MODY, A1c-matched, drug naive type 2 (T2DM) and age-, BMI- sex-matched subjects normal tolerance (NGT). All wore flash monitoring (FGM)...
Objective To investigate the curative effect of estrogen therapy on urinary tract infection type 2 diabetes mellitus in postmenopausal women. Methods Eithty-three women who had were enrolled and randomly divided to receive antibiotic therapy(levofloxacin was used before obtaining drug susceptibility results) alone (control group) or combination with estradiol gel (treatment group). The clinical efficacy bacteriological therapeutic two groups evaluated. Results treatment group better than...
Objective To investigate the main clincal characteristics of coronary angiograph and relation with clinical conoary fasting plasma glucose (FPG),glycosylated hemoglobin ( HbA1c ),low density lipoprein LDL - C ),high HDL C),triglyceride (TG) cholesterol TC ) in newly diagnosed heart disease (CHD).Methods One hundred twenty six CHD patients by undergoing angiography from our hospital were retrospectively analyzed then all devided into type 2 diabetes group no patient blood...
Objective To compare the effects of continuous subcutaneous insulin infusion by pump and multiple injection in patients with gestational diabetes mellitus (GDM).Methods Thirty GDM observation group were treated insulim pump,30 control injection.The pregnancy complication,the incidence hypoglycemia prevalence fetal disease analyzed.Statistical analysis was performed SPSS 11.O.Results There significant differences between two groups hypoglycemia,the (P ＜ 0.05).Conclusions In treatment GDM,the...
Objective To explore the mechanism of bone marrow-derived endothelial progenitor cells(EPCs)in treatment peripheral neuropathy diabetic rats. Methods Rats with neuropathy(DPN)were induced by streptozotocin(60 mg/kg). Male SD rats were divided into normal control group(NC group), DPN group, DPN+ saline group(DPN+ S and EPCs group. Sciatic nerve motor conduction velocity(MNCV)was measured. The expressions NF-κB myelin basic protein(MBP)in sciatic detected...