A5058749164- Herpesvirus Infections and Treatments
- Alzheimer's disease research and treatments
- vaccines and immunoinformatics approaches
- Retinal and Optic Conditions
- Sulfur Compounds in Biology
- Autophagy in Disease and Therapy
- Cardiac Ischemia and Reperfusion
- SARS-CoV-2 and COVID-19 Research
- Phytoestrogen effects and research
- Syphilis Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Viral Infections and Vectors
- Virus-based gene therapy research
- Immune responses and vaccinations
- Graphene and Nanomaterials Applications
- CRISPR and Genetic Engineering
- Advanced Cellulose Research Studies
- Nanoparticle-Based Drug Delivery
- Alcohol Consumption and Health Effects
- Parkinson's Disease Mechanisms and Treatments
- Zoonotic diseases and public health
- Nanoplatforms for cancer theranostics
- Effects of Radiation Exposure
- Bioactive natural compounds
Second Affiliated Hospital of Zhengzhou University
2018-2024
Henan University
2015-2016
First Affiliated Hospital of Henan University
2014-2015
Nonalcoholic fatty liver disease (NAFLD) is the most common in world. Hydrogen sulfide (H2S) plays an important role physiology and pathophysiology of liver. However, whether exogenous H2S could mitigate hepatic steatosis mice remains unclear. The aim this study to evaluate effects on liver.C57BL/6 were fed with either a high-fat diet (HFD) or normal fat (NFD) for 16 weeks. After 12 weeks feeding, HFD-fed injected one time per day NaHS saline followed 4 weeks.Compared NFD, HFD induce...
Currently, the selenium-doped hydroxyapatite (Se-HAp) nanoparticles have received immense therapeutic and tissue repairing values owing to their antitumor activities. However, a high concentration of Se is toxic towards normal stem cells whereas its low cannot effectively remove cancer cells. Therefore, current study was aimed improve anticancer activity Se-HAp through catechins (CC) modification value. The sequentially developed modified nanocomposites (CC/Se-HAp) were characterized for...
The Varicella Zoster Virus (VZV) presents a global health challenge due to its dual manifestations of chickenpox and shingles. Despite vaccination efforts, incomplete coverage, waning immunity lead recurrent infections, especially in aging immunocompromised individuals. Existing vaccines prevent but can trigger the reactivation To address these limitations, we propose polyvalent multiepitope subunit vaccine targeting key envelope glycoproteins VZV. Through bioinformatics approaches, selected...
Abstract Varicella is a highly prevalent infectious disease with similar transmission pathway to coronavirus 2019 (COVID‐19). In the context of COVID‐19 pandemic, anti‐COVID‐19 nonpharmaceutical interventions (NPIs) have been implemented prevent spread infection. This study aims analyze varicella's epidemiological characteristics and further investigate effect NPIs on varicella in Xi'an, northwestern China. Based surveillance data, search engine indices, meteorological factors from 2011 2021...
Serum levels of β-amyloid (A) peptides may represent an early biomarker in the diagnosis Alzheimer's disease (AD). In present study, we investigated temporal kinetic changes serum Aβ 1-42 and 40 amyloid precursor protein (APP)/presenilin (PS)1 double transgenic mouse model AD. peptide 2-, 3-, 6-, 9- 18-month old, liver 1-40 level 6-month old mice were measured using enzyme-linked immunosorbent assay (ELISA) kits. Results revealed that peaked 3-month mice, non-transgenic is comparable liver....
Quetiapine, an atypical antipsychotic drug, may have beneficial effects in Alzheimer's disease (AD), and the effect of quetiapine on object recognition memory AD has never been measured. The aim present study was to evaluate oxidative stress that could be involved pathogenesis amyloid precursor protein/presenilin-1 double transgenic mouse model AD. Nontransgenic mice were treated with (0 or 5 mg/kg/day) drinking water from age 2 months. After 10 months continuous administration, impairment...
Previous studies have suggested that the cerebral microglia activation was associated with Aβ plaques, whereas quetiapine, an atypical antipsychotic drug, decreased levels in Alzheimer's disease (AD) mice. The aim of present study to evaluate effects quetiapine on microglial amyloid precursor protein/presenilin-1 double transgenic mouse model AD. Nontransgenic and mice were treated (0 or 5 mg/kg/day) drinking water from age 2 months. After 10 months continuous administration, killed,...
Varicella is a highly prevalent infectious disease with similar transmission pathway to coronavirus 2019 (COVID-19). In the context of COVID-19 pandemic, anti-COVID-19 non-pharmaceutical interventions (NPIs) have been implemented prevent spread infection. This study aims analyze varicella’s epidemiological characteristics and further investigate effect NPIs on varicella in Xi’an, northwestern China. Based surveillance data, search engine indices, meteorological factors from 2011 2021...
Introduction: Microglia become activated and monocytes macrophages following intracerebral hemorrhage (ICH). They are often called “microglia/macrophage” since it is difficult to differentiate between them. The neutrophils also infiltrate into the injured brain after ICH. Those cells capable of releasing numerous detrimental mediators. Hypothesis: activation microglia/macrophage infiltrated promote injury ICH that inhibition both them attenuates Methods: 10-μl autologous blood obtained from...
The number of measles cases reported worldwide has increased in recent years, and 2015, there was a outbreak Xi’an, China. However, the epidemiology seroepidemiology healthy people after 2015 have not been fully understood. We collected fingertip blood samples from around each suspected case Xi’an 2016-2018 tested IgG using ELISA. Eighty were 2016–2018, with an average annual incidence 0.29 per 100,000 persons. Children aged ≤ 5 years adults 25-29 accounted for large proportion cases. More...