A5042773174- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Landslides and related hazards
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Remote Sensing and Land Use
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Amyotrophic Lateral Sclerosis Research
- Stress Responses and Cortisol
- Cell death mechanisms and regulation
- Nerve injury and regeneration
- Neurological Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Tree Root and Stability Studies
- Spinal Cord Injury Research
- Nanoparticle-Based Drug Delivery
- Geotechnical Engineering and Underground Structures
- Geotechnical Engineering and Analysis
- Parkinson's Disease Mechanisms and Treatments
- Tissue Engineering and Regenerative Medicine
- Electrochemical sensors and biosensors
- Anatomy and Medical Technology
- Muscle Physiology and Disorders
University of Manitoba
2016-2025
Korea Aerospace University
2024
Beijing University of Chinese Medicine
2024
Hebei North University
2018-2023
Chinese Center For Disease Control and Prevention
2023
Children's Hospital Research Institute of Manitoba
2012-2021
Iran University of Medical Sciences
2020
Shantou University Mental Health Center
2017-2020
Southwest Medical University
2020
Shantou University
2020
Amyotrophic lateral sclerosis (ALS) involves motor neuron degeneration, skeletal muscle atrophy, paralysis, and death. Mutations in Cu,Zn superoxide dismutase (SOD1) are one cause of the disease. Mice transgenic for mutated SOD1 develop symptoms pathology similar to those human ALS. To understand disease mechanism, we developed a simple behavioral assay progression mice. Using this assay, defined four stages mice expressing G93A mutant SOD1. By studying with stages, tied several pathological...
Autophagy is a self-digestion process important for cell survival during starvation. It has also been described as form of programmed death. Mitochondria are regulators autophagy-induced death and damaged mitochondria often degraded by autophagosomes. Inhibition the mitochondrial electron transport chain (mETC) induces through generating reactive oxygen species (ROS). The role mETC inhibitors in unknown. Herein, we determined that complex I (rotenone) II (TTFA) induce autophagy transformed...
This study develops novel pH and reduction dual-sensitive micelles for the anticancer drug doxorubicin (DOX) delivery owing to fact that tumor tissues show low high environment. These sub-100 nm present a core-shell structure under physiological conditions, but quickly release loaded drugs responding acidic reductive stimuli. With disulfide bonds in each repeat unit of poly(β-amino ester)s, copolymer was synthesized via Michael addition polymerization from 2,2'-dithiodiethanol diacrylate,...
SUMMARY Aims: To determine the extent to which autophagy contributes neuronal death in cerebral hypoxia and ischemia. Methods: We performed immunocytochemistry, western blot, cell viability assay, electron microscopy analyze activities vitro vivo. Results: In both primary cortical neurons SH‐SY5Y cells exposed oxygen glucose deprivation (OGD)for 6 h reperfusion (RP) for 24, 48, 72 h, respectively, an increase of was observed as determined by increased ratio LC3‐II LC3‐I Beclin‐1 (BECN1)...
Summary Introduction A basal level of mitophagy is essential in mitochondrial quality control physiological conditions, while excessive contributes to cell death a number diseases including ischemic stroke. Signals regulating this process remain unknown. BNIP 3, pro‐apoptotic BH 3‐only protein, has been implicated as regulator mitophagy. Aims Both vivo and vitro models stroke, well 3 wild‐type knock out mice were used study. Results We show that its homologue 3L ( NIX ) are highly expressed...
Sleep is thought to be restorative in function, but what restored during sleep unclear. Here we tested the hypothesis that increased periods of wakefulness will result decreased levels glycogen, principal energy store brain, and with recovery glycogen replenished, thus representing a homeostatic component drive. Using high-energy focused microwave irradiation method kill animals thereby snap-inactivate glycogen-producing -metabolizing enzymes, determined, accuracy precision, brain showed...
A study of the source blood supply to anterolateral femoral flap was carried out on 42 lower limbs adult cadavers (among them 35 with injection red latex and 1 india ink into arteries 6 vascular cast specimens), surface locations pedicle were detected 50 healthy adults. It found that descending branch lateral circumflex vessel an ideal axial vessel. There are constant perforating branches myocutaneous artery or cutaneous from intermuscular space skin. The area extends about 12 x 30 cm....
Abstract Glutamate, a major excitatory neurotransmitter in the CNS, plays critical role neurological disorders such as stroke and Parkinson’s disease. Recent studies have suggested that glutamate excess can result form of cell death called glutamate‐induced oxytosis. In this study, we explore protective effects necrostatin‐1 (Nec‐1), an inhibitor necroptosis, on We show Nec‐1 inhibits oxytosis HT‐22 cells through mechanism involves increase cellular glutathione (GSH) levels well reduction...
The cuprizone mouse model of demyelination was used to investigate the influence that white matter changes have on different magnetic resonance imaging results. In vivo T 2 ‐weighted and magnetization transfer images (MTIs) were acquired weekly in control ( n = 5) cuprizone‐fed mice, with significant increases signal intensity p < 0.001) lower ratio corpus callosum mice starting at 3 weeks peaking 4 5 weeks, respectively. Diffusion tensor (DTI), quantitative MTI (qMTI), 1 / measurements...
Abstract. Prediction of the landslide development process is always a hot issue in research. So far, many methods for displacement series prediction have been proposed. The support vector machine (SVM) has proved to be novel algorithm with good performance. However, performance strongly depends on right selection parameters (C and γ) SVM model. In this study, we present an application genetic (GA–SVM) method parameter optimization rate prediction. We selected typical large-scale...
Astrocytic proliferation and hypertrophy (astrogliosis) are associated with neuronal injury. However, neither the temporal nor spatial relationship between astrocytes injured neurons is clear, especially in neurodegenerative diseases. We investigated these questions a mouse amyotrophic lateral sclerosis (ALS) model. The initial increase astrogliosis coincided onset of clinical disease massive mitochondrial vacuolation motor neurons. After onset, increased further parallel number degenerating...
Alzheimer's disease (AD) is a progressive neurodegenerative associated with senile beta-amyloid (Abeta) plaques and cognitive decline. Neurogenesis in the adult hippocampus implicated regulating learning memory, increased human postmortem brain of AD patients. However, little currently known about changes hippocampal neurogenesis progression AD. As tissues from patients during are generally not available, an amyloid precursor protein (APP)/presenilin1 (PS1) double transgenic mouse model was...
Nanocoating of a single-cell with biocompatible materials creates defined microenvironment for cell differentiation and proliferation, as well model studies in biology. In addition, the acidic environment tissue stroke victims necessitates drug release upon pH stimuli. Here, we report encapsulation single neural stem cells (NSCs) using layer-by-layer (LbL) self-assembly technique polyelectrolytes gelatin alginate. Analysis NSCs showed that LbL would not affect viability, or cells. When...
Abstract Connexin43 (Cx43) is one of the most abundant gap junction proteins in central nervous system. Abnormal opening Cx43 hemichannels after ischemic insults causes apoptotic cell death. In this study, we found persistently increased expression 8 h to 7 d hypoxia/ischemia (HI) injury neonatal rats. Pre‐treatment with Gap26 and Gap27, two mimetic peptides, significantly reduced cerebral infarct volume. treatment at 24 ischemia improved functional recovery on muscle strength, motor...
Summary Aims Both amyloid deposition and neuroinflammation appear in the early course of Alzheimer's disease ( AD ). However, progression its relationship with behavioral changes have not been fully elucidated. A better understanding role might extend our current knowledge to therapeutic intervention possibilities. Methods This study systematically characterized abnormalities APP / PS 1 transgenic mice. Brain pathology measures were performed post‐mortem brain tissues mice from 2 22 months....