A5027324909- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Multiple Sclerosis Research Studies
- MRI in cancer diagnosis
- Neuroscience and Neuropharmacology Research
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Systemic Lupus Erythematosus Research
- Tensor decomposition and applications
- Lymphoma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Neurological Complications and Syndromes
- Wireless Power Transfer Systems
- NMR spectroscopy and applications
- Image and Signal Denoising Methods
- Bone and Joint Diseases
- Neurological Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Glioma Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Prion Diseases and Protein Misfolding
- Granular flow and fluidized beds
- Caveolin-1 and cellular processes
University of Winnipeg
2013-2024
Anhui University
2023
University Hospital Ulm
2019-2020
University of Manitoba
2010-2018
Hadassah Medical Center
2015
Lawson Health Research Institute
2015
Western University
2015
St. Boniface Hospital
2015
University of Lethbridge
2015
Therapeutics Clinical Research
2012
The cuprizone mouse model of demyelination was used to investigate the influence that white matter changes have on different magnetic resonance imaging results. In vivo T 2 ‐weighted and magnetization transfer images (MTIs) were acquired weekly in control ( n = 5) cuprizone‐fed mice, with significant increases signal intensity p < 0.001) lower ratio corpus callosum mice starting at 3 weeks peaking 4 5 weeks, respectively. Diffusion tensor (DTI), quantitative MTI (qMTI), 1 / measurements...
Brain 18F-FDG PET images are commonly-known materials for effectively predicting Alzheimer's disease (AD). How-ever, the data volume of is usually insufficient, which unfavorable to train an accurate AD prediction networks. Fur-thermore, image noisy with low signal-to-noise ratio, and simultaneously feature (metabolic abnormality) used in not always obvious. Such charac-teristics hinder existing deep learning networks learn lesion (i.e., glucose metabolism effectively, leads unsatisfactory...
We present an archetypal set of three-dimensional digital atlases the quail embryo based on microscopic magnetic resonance imaging (microMRI). The are composed three modules: (1) images fixed ex ovo quail, ranging in age from embryonic day 5 to 10 (e05 e10); (2) a coarsely delineated anatomical atlas microMRI data; and (3) organ system-based hierarchical graph linked delineations. is designed be accessed using SHIVA, free Java application. extensible can contain other types information...
The myelin basic protein (MBP) gene encodes two families of proteins, the classic MBP constituents and golli-MBPs, function which is less well understood. In this study, targeted ablation but not MBPs, resulted in a distinct phenotype unlike that knock-outs (KOs) MBPs or other proteins. Although golli KO animals did display an overt dysmyelinating phenotype, they exhibit delayed and/or hypomyelination selected areas brain, such as visual cortex optic nerve, determined by Northern Western...
Visually evoked potentials (VEPs) and micro magnetic resonance imaging (micro MRI) are widely used as noninvasive techniques for diagnosis of central nervous system (CNS) diseases, especially myelin such multiple sclerosis. Here we use these in tandem to validate the vivo data mouse models. We shiverer mutant mouse, which has little or no CNS myelin, a test model. These show that (MBP(shi)/MBP(shi)) VEP latency is 30% longer than its wild-type sibling. Surprisingly, heterozygous (MBP(shi)/+)...
A diagnosis of Alzheimer's disease (AD), a neurodegenerative disorder accompanied by severe functional and cognitive decline, is based on clinical findings, with final confirmation the at autopsy presence amyloid-β (Aβ) plaques neurofibrillary tangles. Given that microstructural brain alterations occur years prior to symptoms, efforts detect changes early could significantly enhance our ability diagnose AD sooner. Diffusion tensor imaging (DTI), type MRI characterizes magnitude, orientation,...
Abstract Inductively coupled radiofrequency (RF) coils are an inexpensive and simple method to realize wireless RF in magnetic resonance imaging (MRI), which can significantly ease the MRI scan setup improve patient comfort because they do not require bulky components such as cables, baluns, preamplifiers, connectors. However, volume‐type typically operated transmit/receive mode detuning is much more challenging due their complex structure multiple resonant modes. Meanwhile, adding too many...
Summary Mutations in SOCS1 are frequent primary mediastinal B‐cell lymphoma and classical Hodgkin lymphoma. In the latter, mutations affect length of encoded protein (major mutations) associated with shorter patient survival. Two independent studies examined prognostic impact diffuse large (DLBCL) showed differing results. This may be due to small number included patients, heterogeneity patients’ demographics distinct treatment schemes these studies. To overcome size limitations previous...
Activation of adenosine A1 receptors has neuroprotective effects in animal stroke models. Adenosine levels are regulated by nucleoside transporters. In vitro studies showed that neuron-specific expression human equilibrative transporter 1 (hENT1) decreases extracellular and receptor activity. this study, we tested the effect hENT1 on cortical infarct size following intracerebral injection vasoconstrictor endothelin-1 (ET-1) or saline.Mice underwent stereotaxic intracortical ET-1 (1 μl; 400...
This article explains some simple experiments that can be used in undergraduate or graduate physics biomedical engineering laboratory classes to learn how birdcage volume radiofrequency (RF) coils and magnetic resonance imaging (MRI) work. For a clear picture, do any quantitative MRI analysis, acquiring images with high signal-to-noise ratio (SNR) is required. With given system at field strength, the only means change SNR using hardware RF coil collect image. designed many different ways...
There appear to be species differences among the effects of gene mutations related familial Alzheimer's disease on brain during aging. To gain a better understanding Swedish mutation amyloid precursor protein and mutant form human presenilin 1 mice, commercially available mice from Jackson Laboratory were studied. Three dimensional T2 * -weighted imaging was used monitor size brains APP/PS1 monthly, 6 13 months age. No significant difference measured in medial-lateral width, dorsal-ventral...
The advent of highly effective treatments targeting the disease biology chronic lymphocytic leukemia (CLL) has transformed therapeutic field tremendously. However, transformation into an aggressive B-cell lymphoma, called Richter syndrome (RS), remains challenging since treatment options for this condition are still insufficient. Exploratory drug testing and experimental studies restricted by lack satisfactory models. We have established U-RT1, a cell line derived from proliferating RS...