A5100350722- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Receptor Mechanisms and Signaling
- Immune Response and Inflammation
- Organ Transplantation Techniques and Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Autophagy in Disease and Therapy
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Traditional Chinese Medicine Analysis
- Adipose Tissue and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Respiratory Support and Mechanisms
- Vagus Nerve Stimulation Research
- Intensive Care Unit Cognitive Disorders
- Neuropeptides and Animal Physiology
- Inflammatory mediators and NSAID effects
- Anesthesia and Pain Management
- Pharmaceutical studies and practices
- Cardiac Arrest and Resuscitation
- Neurological Disease Mechanisms and Treatments
- Peroxisome Proliferator-Activated Receptors
Capital Medical University
2025
Otsuka Pharmaceutical (Spain)
2025
Wuhan University
2014-2024
Zhongnan Hospital of Wuhan University
2014-2024
First Affiliated Hospital of Zhengzhou University
2024
Peking University
2024
Hubei University of Technology
2024
International Peace Maternity & Child Health Hospital
2017-2023
Shanghai Jiao Tong University
2013-2023
Otsuka (United States)
2021-2023
Kidney is one of the most vulnerable organs in sepsis, resulting sepsis-associated acute kidney injury (SA-AKI), which brings about not only morbidity but also mortality sepsis. Ferroptosis a new kind death type cells elicited by iron-dependent lipid peroxidation, participates pathogenesis The aim this study was to verify occurrence ferroptosis SA-AKI and demonstrate that post-treatment with irisin could restrain alleviate via activating SIRT1/Nrf2 signaling pathway. We established model...
Irisin, a 112-amino acid peptide induced with exercise in mice and human is thought to have correlation the short-term outcomes of patients ischemic stroke. In present study, neuroprotective effects irisin were evaluated vivo vitro its underlying mechanism was also explored. The global cerebral ischemia/reperfusion (I/R) model established by bilateral common carotid artery occlusion for 20 min reperfusion 24 h oxygen-glucose deprivation/reperfusion HT22 cells. Neurological function scored...
Iron-dependent lipid peroxidation causes ferroptosis. This study was aimed at verifying that irisin postconditioning can inhibit ferroptosis and minimize lung ischemia/reperfusion (I/R) damage via activating the Nrf2/HO-1 signal axis. We constructed a murine model of I/R damage. At onset reperfusion, irisin, inhibitor ferrostatin-1, inducer Fe-citrate were all administered. discovered could reduce injury, consistent with ferrostatin-1's action. Furthermore, suppressed in damage, as evidenced...
Microglia pyroptosis-mediated neuroinflammation is thought to be the crucial pathogenesis of sepsis-associated encephalopathy (SAE). Erbin has been reported associated with various inflammatory diseases. However, role in SAE and relationship between microglia pyroptosis are unknown. In this study, we investigated promising underlying molecular mechanism regulation pyroptosis.WT knockout mice underwent cecum ligation perforation (CLP) induce SAE. Primary mouse BV2 cells were treated...
Human amniotic fluid cells (hAFCs) may differentiate into multiple cell lineages and thus have a great potential to become donor source for regenerative medicine. The ability of hAFCs germ oocyte-like has been previously documented. Herein we report the use help restore follicles in clinical condition involving premature ovarian failure.Human was obtained via amniocentesis, yielding subpopulation cloned that able form embryoid bodies (EBs) three embryonic layers. Moreover, culture EBs medium...
Long-term infection with Helicobacter pylori ( H. pylori) leads to elevated serum gastrin levels, which are closely related gastric cancer. Eradication of H . treat the high levels is increasingly challenged by antibiotic resistance. Dopamine (DA) receptor 1 (D R) expressed on G cells in antrum. Parietal produce DA, inhibits somatostatin (SOM) release through D 2 R mucosa. Whether targeted intervention DRs can improve after remains be explored. In this study, human tissue, pylori-infected...
Neurocognitive impairment risk increases with age and is further enhanced after anaesthesia, resulting in significant long-term morbidity an overall reduced quality of life. Metformin activates autophagy, a key process that protects against cognitive dysfunction. We hypothesized metformin mitigates sevoflurane-induced neurocognitive by regulating autophagy explored the underlying molecular mechanisms aged mice. Twenty-month-old mice were exposed to 3 % sevoflurane for 2 h or without...
Honokiol, a potent radical scavenger, has been demonstrated to ameliorate cerebral infarction following ischemia/reperfusion (I/R) injury. However, its effects on myocardial I/R injury remain unclear. The present study aimed examine the of honokiol and investigate potential cardioprotective mechanisms. Sprague-Dawley rats were pretreated with exposed 30-min ischemia followed by 2-h coronary reperfusion. Myocardial I/R-induced infarct size biochemical histological changes compared. expression...
Many studies have reported that microRNAs participate in neuropathic pain development. Previously, miR-200b and miR-429 are to be involved various diseases. In our current study, we focused on their roles found were significantly decreased chronic constriction injury (CCI) rat spinal cords isolated microglials. overexpression able relieve through modulating PWT PWL CCI rats. Meanwhile, observed both upregulation could repress neuroinflammation via inhibiting inflammatory cytokines such as...
Irisin, which can be released in the hippocampus after physical exercise, is demonstrated to have beneficial effects on neurovascular diseases. This study investigated impact of exercise linked‐irisin mortality and cognition a mice model cerebral ischemia further explored its underlying mechanism. The cerebrospinal concentrations irisin klotho from ischemic stroke patients were measured with an enzyme‐linked immunosorbent assay (ELISA). cognitive function was evaluated by series behavioural...
Exploring effective methods to lessen myocardial ischemia-reperfusion injury still has positive significance. The adenosine A2a receptor (A2aR) played a crucial part in cardiac injury. Previous studies revealed that the regulated autophagy, but specific mechanism was unclear. We established an model (30 min of ischemia and 2 h reperfusion) vivo with oxygen-glucose deprivation for 6 reoxygenation 18 (OGDR) vitro . resulted prolonged QTc interval, left ventricular systolic dysfunction,...
Recent research indicates that brain cannabinoid CB2 receptors are involved in drug reward and addiction. However, it is unclear whether β-caryophyllene (BCP), a natural product with receptor agonist profile, has therapeutic effects on methamphetamine (METH) abuse dependence. In this study, we used animal models of self-administration, electrical brain-stimulation (BSR) vivo microdialysis to explore the BCP METH-taking METH-seeking behavior. We found systemic administration dose-dependently...
Due to the customary delay between medication approvals in adult and adolescent populations, adolescents with schizophrenia may receive off-label antipsychotic treatment, without empirically justified dosing recommendations. In order accelerate pediatric drug development, US Food Drug Administration (FDA) released a general advice letter sponsors permitting effectiveness of atypical antipsychotics for treatment adults be extrapolated based on pharmacokinetic (PK) analysis support dose...
Methotrexate (MTX) is an anchor drug used to treat rheumatoid arthritis (RA), but responsiveness variable in effectiveness and toxicity. its polyglutamate conjugates (MTXPG(n)) red blood cells (RBC) have been associated with patient response. In the current study, 13 collagen-induced arthritic (CIA) rats 12 healthy were given subcutaneous doses of either saline or 0.3 1.5 mg/kg per 2 days MTX from day 21 43 post-induction. Blood samples obtained at various times measure plasma, MTXPG(n) RBC....