A5101856916- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Anesthesia and Pain Management
- Heme Oxygenase-1 and Carbon Monoxide
- Anesthesia and Sedative Agents
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
- Cannabis and Cannabinoid Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Inflammatory mediators and NSAID effects
- Neuroscience of respiration and sleep
- High Altitude and Hypoxia
- Cardiac, Anesthesia and Surgical Outcomes
- Parasite Biology and Host Interactions
- Nausea and vomiting management
Zhongnan Hospital of Wuhan University
2016-2025
Wuhan University
2016-2025
Huazhong Agricultural University
2016
Iron-dependent lipid peroxidation causes ferroptosis. This study was aimed at verifying that irisin postconditioning can inhibit ferroptosis and minimize lung ischemia/reperfusion (I/R) damage via activating the Nrf2/HO-1 signal axis. We constructed a murine model of I/R damage. At onset reperfusion, irisin, inhibitor ferrostatin-1, inducer Fe-citrate were all administered. discovered could reduce injury, consistent with ferrostatin-1's action. Furthermore, suppressed in damage, as evidenced...
Microglia pyroptosis-mediated neuroinflammation is thought to be the crucial pathogenesis of sepsis-associated encephalopathy (SAE). Erbin has been reported associated with various inflammatory diseases. However, role in SAE and relationship between microglia pyroptosis are unknown. In this study, we investigated promising underlying molecular mechanism regulation pyroptosis.WT knockout mice underwent cecum ligation perforation (CLP) induce SAE. Primary mouse BV2 cells were treated...
Abstract Objective To investigate whether irisin could protect against blood–brain barrier (BBB) dysfunction following focal cerebral ischemia/reperfusion in rats. Methods and Materials Seventy‐two adult male Sprague Dawley rats weighing 280–320 g were randomly divided into three groups: sham operation group (S), (FC), (IR). Focal ischemia was induced by improved thread occlusion of right middle artery (MCAO) for 2 hr followed reperfusion 24 After reperfusion, the neurological evaluation...
The purpose of this study was to compare the effects scalp nerve block (SNB) and local anesthetic infiltration (LA) with 0.75% ropivacaine on postoperative inflammatory response, intraoperative hemodynamic pain control in patients undergoing craniotomy. Fifty-seven were admitted for elective craniotomy surgical clipping a cerebral aneurysm. They randomly divided into three groups: Group S (SNB 15 mL ropivacaine), group I (LA ropivacaine) C (that only received routine intravenous analgesia)....
Postoperative delirium (POD) is a common complication following surgery and anesthesia (Surgery/Anesthesia). Mitochondrial dysfunction, which demonstrated by energy deficits excessively activated oxidative stress, has been reported to contribute POD. The dynamic balance between mitochondrial fusion fission processes critical in regulating function. However, the impact of Surgery/Anesthesia on fusion/fission dynamics remains unclear. Here, we evaluate effects laparotomy under 1.4% isoflurane...
Sleep benefits the restoration of energy metabolism and thereby supports neuronal plasticity cognitive behaviors. Sirt6 is a NAD+-dependent protein deacetylase that has been recognized as an essential regulator because it modulates various transcriptional regulators metabolic enzymes. The aim this study was to investigate influence on cerebral function after chronic sleep deprivation (CSD). We assigned C57BL/6J mice control or two CSD groups subjected them AAV2/9-CMV-EGFP...
BackgroundSleep disorders can profoundly affect neurological function. We investigated changes in social and anxiety-related brain functional connectivity induced by sleep deprivation, the potential therapeutic effects of general anaesthetics propofol sevoflurane rats.MethodsTwelve-week-old male Sprague–Dawley rats were subjected to deprivation for 20 h per day (from 14:00 10:00 next day) 4 consecutive weeks. They free from remaining during which they received (40 mg kg–1 i.p.) or (2% 2 h)...
ABSTRACT Aims The comorbidity of anxiety‐like symptoms in neuropathic pain (NP) is a significant yet often overlooked health concern. Anxiety sufferers may have lower tolerance for pain, but which difficult to treat. Accumulating evidence suggests strong link between astrocytes and the manifestation NP with concurrent behaviors. And anterior cingulate cortex (ACC) has emerged as key player modulation related emotional processing. However, complex mechanisms that ACC influence anxiety...
To compare the efficacy of two one-handed face mask ventilation techniques. Secondarily, we also assessed effect hand size on performance both these Eighty subjects were randomized into EO group and EC group. After receiving training, they carried out a simulation model according to order technique-EC technique or technique-EO technique, performed each for five consecutive ventilations. The primary outcomes time first chest undulation total number undulations in operations. A questionnaire...
Patients undergoing surgery frequently develop neuropsychological disturbances, including cognitive decline or memory impairment, and routine clinical procedures such as mechanical ventilation (MV) may affect acute-phase brain outcome. We aimed to investigate the effect of prolonged MV on postoperative dysfunction in surgical mice.Male C57BL/6 mice were randomly divided into following three groups: (1) The control group (group C) comprised anesthetized, unventilated animals; (2) (subgroups...
Haemonchus contortus is one of the most important parasitic nematodes small ruminants around world, particularly in tropical and subtropical regions. The control haemonchosis relies mainly on anthelmintics, but excessive prolonged use anthelmintics causing serious drug resistance issues many countries. As benzimidazole (BZ) have been broadly used China, we hypothesized that widespread. Given link between three known single nucleotide polymorphisms (SNPs, designated F167Y, E198A F200Y)...
Methylene blue (MB) is a long‑term inhibitor of peripheral nerve axons, thereby alleviating or permanently eliminating pain. However, it remains unknown whether MB safe and effective method treating osteoarthritis (OA). was injected into the knee joints rabbits they were monitored for any histological structural changes. The results revealed no evident changes in structure normal joint following injection 1 mg/kg at 1, 4, 8 24 weeks post‑injection. Compared with vehicle control, treatment...
Irisin, which can be released in the hippocampus after physical exercise, is demonstrated to have beneficial effects on neurovascular diseases. This study investigated impact of exercise linked‐irisin mortality and cognition a mice model cerebral ischemia further explored its underlying mechanism. The cerebrospinal concentrations irisin klotho from ischemic stroke patients were measured with an enzyme‐linked immunosorbent assay (ELISA). cognitive function was evaluated by series behavioural...
The mortality risk related to anaesthesia in China remains poorly characterized. objective of this study was evaluate the anaesthesia-related terms its incidence, changes, causes and preventability Hubei, China, between 2017 2021 using a series annual surveys.We prospectively collected information on patient, surgical, anaesthesia, hospital characteristics for 9,391,669 procedures performed 10 cities within Hubei Province, China. Anaesthesia-related death defined as that deemed be entirely...
Intestinal ischemia/reperfusion (I/R) is a clinical emergency, which often causes lung injury with high morbidity and mortality. Although dexmedetomidine has been identified to have protective effect on caused by intestinal I/R, its specific mechanism still elucidated. In recent years, the cannabinoid (CB 2 ) receptor pathway found be involved in I/R of some organs. current study, we investigated whether CB contributes I/R-induced rats. Dexmedetomidine treatment upregulated expression...
Postoperative delirium (POD) is the most common postoperative complication affecting elderly patients, yet underlying mechanism elusive, and effective therapies are lacking. The neuroinflammation hypothesis for pathogenesis of POD has recently emerged. Accumulating evidence supporting role specialized proresolving lipid mediators (SPMs) in regulating inflammation. Neuroprotectin D1 (NPD1), a novel docosahexaenoic acid (DHA)-derived mediator, shown potent immunoresolvent neuroprotective...
Acute lung injury (ALI) leading to respiratory distress is a common sequela of shock or trauma. The toll-like receptors (TLRs) stand at the interface innate immune activation in settings both infection and sterile by responding variety microbial endogenous ligands alike. This work explored effects TLR-4 on hemorrhage-induced ALI characterizes signaling pathways mechanisms involved noninfectious ALI. Mice underwent hemorrhagic resuscitation (HSR). Arterial blood gases; expressions TLR-4, heme...