A5068776593- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Anesthesia and Pain Management
- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Anesthesia and Sedative Agents
- Cardiac Arrest and Resuscitation
- Adipose Tissue and Metabolism
- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Nausea and vomiting management
- Histone Deacetylase Inhibitors Research
- Neuropeptides and Animal Physiology
- Cancer, Stress, Anesthesia, and Immune Response
- Intensive Care Unit Cognitive Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Barrier Structure and Function Studies
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Metabolism, Diabetes, and Cancer
- Cancer Treatment and Pharmacology
- Plant-based Medicinal Research
- Transplantation: Methods and Outcomes
Zhongnan Hospital of Wuhan University
2015-2024
Wuhan University
2015-2024
Air Force Medical University
2016
Irisin, a 112-amino acid peptide induced with exercise in mice and human is thought to have correlation the short-term outcomes of patients ischemic stroke. In present study, neuroprotective effects irisin were evaluated vivo vitro its underlying mechanism was also explored. The global cerebral ischemia/reperfusion (I/R) model established by bilateral common carotid artery occlusion for 20 min reperfusion 24 h oxygen-glucose deprivation/reperfusion HT22 cells. Neurological function scored...
The aim of the study was to investigate effects two anaesthetic techniques (total intravenous technique vs. inhalational technique) on changes in pro- and anti-inflammatory cytokine levels during open cholecystectomy. Forty ASA PS I-II patients undergoing cholecystectomy were randomly assigned groups. Group R received total anaesthesia with propofol remifentanil group F balanced isoflurane. plasma tumour necrosis factor-α (TNF-α), interleukin IL-6 IL-10 measured after surgery....
Quercetin (Que), a plant-derived flavonoid, has multiple benefical actions on the cardiovascular system. The current study investigated whether Que postconditioning any protective effects myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. Male Sprague-Dawley rats were randomly allocated to 5 groups (20 animals/group): sham, I/R, postconditioning, Que+LY294002 [a phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway inhibitor],...
Abstract Objective To investigate whether irisin could protect against blood–brain barrier (BBB) dysfunction following focal cerebral ischemia/reperfusion in rats. Methods and Materials Seventy‐two adult male Sprague Dawley rats weighing 280–320 g were randomly divided into three groups: sham operation group (S), (FC), (IR). Focal ischemia was induced by improved thread occlusion of right middle artery (MCAO) for 2 hr followed reperfusion 24 After reperfusion, the neurological evaluation...
Ischemic stroke has been ranked as the second cause of death in patients worldwide. Inflammation which is activated during cerebral ischemia/reperfusion (I/R) an important mechanism leading to brain injury. The present study aimed investigate effect flurbiprofen axetil on I/R injury and role inflammation this process. Rats were subjected sham operation or global with without (5 10 mg/kg). Global ischemia was achieved by occlusion bilateral common carotid arteries combined hypotension for 20...
Background Mitochondrial dysfunction would ultimately lead to myocardial cell apoptosis and death during ischemia-reperfusion injuries. Autophagy could ameliorate mitochondrial by autophagosome forming, which is a catabolic process preserve the mitochondrial's structural functional integrity. HO-1 induction expression are important protective mechanisms. This study in order investigate role of damage its mechanism. Methods Results The H9c2 cardiomyocyte line were incubated hypoxic then...
Irisin, which can be released in the hippocampus after physical exercise, is demonstrated to have beneficial effects on neurovascular diseases. This study investigated impact of exercise linked‐irisin mortality and cognition a mice model cerebral ischemia further explored its underlying mechanism. The cerebrospinal concentrations irisin klotho from ischemic stroke patients were measured with an enzyme‐linked immunosorbent assay (ELISA). cognitive function was evaluated by series behavioural...
Exploring effective methods to lessen myocardial ischemia-reperfusion injury still has positive significance. The adenosine A2a receptor (A2aR) played a crucial part in cardiac injury. Previous studies revealed that the regulated autophagy, but specific mechanism was unclear. We established an model (30 min of ischemia and 2 h reperfusion) vivo with oxygen-glucose deprivation for 6 reoxygenation 18 (OGDR) vitro . resulted prolonged QTc interval, left ventricular systolic dysfunction,...
This study was undertaken to determine and confer the cardioprotective effects of adenosine A2 receptor (A2AR) its impact on myocardial autophagy in setting reperfusion. We established a rat ischemia model by subjecting rats 30 minutes (I) 120 reperfusion (R). The A2AR agonists CGS21680 (A2aAR specific) BAY60-6583 (A2bAR were administered separately combination 5 before (postconditioning). No visible improvements rats' hemodynamic changes response either CGS or BAY observed compared with...
Glutamate transporter-1 (GLT-1) reduction causes dysregulation of excitatory-inhibitory balance, contributing toward neuropathic pain development. However, the mechanisms underlying GLT-1 downregulation are still unclear. Histone acetylation plays a pivotal role in regulation gene expression. We sought to examine contribution histone on hypersensitivity and deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) was intrathecally infused rats through osmotic pumps from -5 days 7 after...
This study aimed to determine the effect and mechanism of action adenosine 2 receptor (A2R) activation on myocardial ischemia reperfusion injury (MIRI) under diabetic conditions.MIRI type rats H9C2 cardiomyocytes were treated with A2R agonist then subjected hypoxia for 6 h reoxygenation 18 h. Myocardial damage, infarct size determined by cardiac ultrasound. Indicators cardiomyocyte injury, creatine kinase-MB troponin I detected Enzyme Linked Immunosorbent Assay. Endoplasmic reticulum stress...
We explored the effects of direct peritoneal resuscitation with pyruvate-peritoneal dialysis solution (PDS) following intravenous (VR) on intestinal ischemia-reperfusion injury in rats hemorrhagic shock (HS).Fifty were randomly assigned equally to five groups. In group sham, a surgical operation was performed without or resuscitation. VR, subjected only VR. groups NS, LA, and PY, normal saline (NS), lactate-based PDS (Lac-PDS), pyruvate-based (Pyr-PDS), respectively, after Mean arterial...
Direct peritoneal resuscitation with pyruvate (Pyr-PDS) has emerged as an interesting candidate to alleviate injury in diverse organs, while the potential mechanism yet be fully elucidated. To explore effect of autophagy spinal cord ischemia-reperfusion (SCIR) and underlying mechanism, we established a model SCIR vivo vitro. In vivo, male SD rats underwent aortic occlusion for 60 min then followed by intraperitoneally infused 20 mL or normal saline 30 min, cords were removed analysis after...
Puerarin, an active compound of radix puerariae, is a major used in Chinese herbal medicines and it has been well known for its pharmacological effects, including antioxidant, anti‑inflammatory, neuroprotective cardioprotective properties. The aim the present study was to determine role puerarin (Pue) complete Freund's adjuvant (CFA)-induced trigeminal neuralgia (TN) effects this on Sirt1 activity progression CFA-induced TN.Mice were injected with CFA unilateral face induce TN. A cell model...