Background and aims: Diabetic kidney is more sensitive to ischemia/reperfusion (I/R) injury, which associated with increased oxidative stress impaired nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling. Melatonin, a hormone that secreted the rhythm of light/dark cycle, has antioxidative effects in reducing acute injury (AKI). However, molecular mechanism melatonin protection against I/R state diabetes still unknown. In present study, we hypothesized attenuates...

Ischemic stroke is a devastating disease that causes long-term disability. However, its pathogenesis unclear, and treatments for ischemic are limited. Recent studies indicate oxidative stress involved in the pathological progression of angiogenesis participates recovery from stroke. Furthermore, previous have shown Coicis Semen has antioxidative anti-inflammatory effects variety diseases. In present study, we investigated whether protective effect against mechanism this effect.Coicis...

Palmatine (PAL), a natural isoquinoline alkaloid, possesses extensive biological and pharmaceutical activities, including antioxidative stress, anti‐inflammatory, antitumor, neuroprotective, gastroprotective activities. However, it is unknown whether PAL has protective effect against ischemic stroke cerebral ischemia/reperfusion (I/R) injury. In the present study, transient middle artery occlusion (MCAO) mouse model was used to mimic I/R injury in mice. Our study demonstrated that treatment...

Abstract Prussian blue (PB) nanozymes are demonstrated as effective therapeutics for ulcerative colitis (UC), yet an unmet practical challenge remains in the scalable production of these and uncertainty over their efficacy. With a novel approach, series porous manganese‐iron PB (MnPB) colloids, which shown to be efficient scavengers reactive oxygen species (ROS) including hydroxyl radical, superoxide anion, hydrogen peroxide, prepared. In vitro cellular experiments confirm capability...

Background . A strong ongoing intraoperative stress response can cause serious adverse reactions and affect the postoperative outcome. This study evaluated effect of intranasally administered dexmedetomidine (DEX) in combination with local anesthesia (LA) on relief inflammatory during functional endoscopic sinus surgery (FESS). Methods Sixty patients undergoing FESS were randomly allocated to receive either intranasal DEX (DEX group) or saline (Placebo 1 h before surgery. Stress hormones,...

Postoperative pain can cause serious adverse reactions that severely affect postoperative outcome. The present study evaluated the effect of dexmedetomidine (DEX) added to sufentanil in intravenous patient-controlled analgesia (PCA) on relief and inflammatory responses during recovery patients undergoing a combined thoracoscopic-laparoscopic esophagectomy (TLE).Sixty TLE were randomly allocated receive 1 μg/ml alone (Group S) or plus 2.5 DEX D) for (IV) PCA. relief, cumulative PCA...

Myeloid immune cells are abundant in both ruptured and unruptured brain arteriovenous malformations (bAVMs). The role of central nervous system (CNS) resident circulating monocyte-derived macrophages bAVM pathogenesis has not been fully understood. We hypothesize that CNS enhance development hemorrhage. RNA sequencing using cultured endothelial (ECs) mouse samples revealed downregulation two causative genes, activin-like kinase 1

Abstract Ischemic stroke represents a significant global health challenge, frequently associated with intricate pathophysiological alterations. During ischemic stroke, the generation of reactive oxygen species markedly increases, leading to direct neuronal damage as well initiating cascade inflammatory responses. This oxidative stress can also disturb equilibrium gut microbiota, resulting in dysbiosis. In turn, an imbalance microbiota further exacerbate production and contribute...

Ischemic stroke has been ranked as the second cause of death in patients worldwide. Inflammation which is activated during cerebral ischemia/reperfusion (I/R) an important mechanism leading to brain injury. The present study aimed investigate effect flurbiprofen axetil on I/R injury and role inflammation this process. Rats were subjected sham operation or global with without (5 10 mg/kg). Global ischemia was achieved by occlusion bilateral common carotid arteries combined hypotension for 20...

A high level of vascular endothelial growth factor (VEGF) has been implicated in brain arteriovenous malformation (bAVM) bleeding and rupture. However, direct evidence is missing. In this study the authors used a mouse bAVM model to test hypothesis that elevation focal VEGF levels bAVMs exacerbates severity hemorrhage.

Background . Previous research has shown that peroxiredoxin 1 (Prdx1) is an important modulator of physiological and pathophysiological cardiovascular events. This study aimed at investigating the role underlying mechanism Prdx1 in doxorubicin- (DOX-) induced cardiotoxicity. Cardiac-specific expression was mice, mice received a single dose DOX (15 mg/kg) to generate First, our demonstrated upregulated heart cardiomyocytes after treatment. Second, we provided direct evidence overexpression...

The aim of this study was to investigate the effects transforming growth factor-β1 (TGF-β1) and interleukin‑1β (IL-1β) on expression a disintegrin metalloproteinase with thrombospondin motifs (ADAMTS) enzymes their inhibitor, tissue inhibitor 3 (TIMP-3), in human intervertebral disc (IVD) degeneration. Cells from patients IVD degeneration were cultured Dulbecco's modified Eagle's medium Ham's F12 nutrient mixture (DMEM/F12) at 37˚C 5% CO2 incubator. Cell proliferation measured by cell...

Methylene blue (MB) is a long‑term inhibitor of peripheral nerve axons, thereby alleviating or permanently eliminating pain. However, it remains unknown whether MB safe and effective method treating osteoarthritis (OA). was injected into the knee joints rabbits they were monitored for any histological structural changes. The results revealed no evident changes in structure normal joint following injection 1 mg/kg at 1, 4, 8 24 weeks post‑injection. Compared with vehicle control, treatment...

Pro-resolving mediators (PRMs) are considered as emerging analgesics for chronic pain. Maresin 1 (MaR1) is a newly identified member of PRMs, and recent studies implicate its potential role in some pain conditions. As the function MaR1 neuropathic remains unclear, we investigated effects on hypersensitivity underlying mechanism using rat spinal nerve ligation (SNL) model pain.MaR1 (100 ng/10 μL) or commensurable artificial cerebrospinal fluid was delivered via intrathecal catheter from days...

Background . Comparing the effect of two different κ ‐receptor agonists, nalbuphine and oxycodone, regular morphine in patients for prophylactic analgesia acute pain after daytime laparoscopic cholecystectomy. Methods One hundred twenty‐four undergoing cholecystectomy were randomly allocated to receive (group N), oxycodone O), M). The three groups all given intravenous injection (iv.) 0.15 mg/kg before incision 0.05 at end pneumoperitoneum. Visual Analogue Scale (VAS) scores (incision,...

JOURNAL/nrgr/04.03/01300535-202411000-00028/figure1/v/2024-04-10T160327Z/r/image-tiff Calcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury. Various calcium channels are involved in Cav3.2 channel is a main subtype of T-type channels. blockers, such as pimozide and mibefradil, have been shown to prevent injury-induced brain However, the role injury remains unclear. Here, vitro vivo models were established using middle artery occlusion mice high...

Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. might be effective in combination with sevoflurane for anesthesia, but prospective randomized controlled clinical trials which to verify this hypothesis are lacking. In total, 120 patients who underwent embolization of an intracranial aneurysm were recruited from Anhui Provincial Hospital Renmin Wuhan University China randomly allocated two groups. After intraoperative administration 2% 3%...

Pregnancy-induced hypertension (PIH) causes significant maternal and fetal morbidity mortality. A decreased number of regulatory T (Treg) cells is associated with the pathogenesis PIH. The programmed cell death-1 (PD-1)/PD-ligand 1 (PD-L1) pathway critical to normal pregnancy (NP) by promoting Treg development. However, relationship between PD-1/PD-L1 differentiation in PIH has not been fully elucidated. In this study, venous blood was obtained from 20 NP 58 patients. Peripheral mononuclear...