The outbreak of 2019 novel coronavirus disease (COVID-19) in Wuhan, China, has spread rapidly worldwide. In the early stage, we encountered a small but meaningful number patients who were unintentionally scheduled for elective surgeries during incubation period COVID-19. We intended to describe their clinical characteristics and outcomes.We retrospectively analyzed data 34 underwent COVID-19 at Renmin Hospital, Zhongnan Tongji Hospital Central from January 1 February 5, 2020.Of operative...

The reactive oxygen species- (ROS-) induced nod-like receptor protein-3 (NLRP3) inflammasome triggers sterile inflammatory responses and pyroptosis, which is a proinflammatory form of programmed cell death initiated by the activation caspases. NLRP3 plays an important role in myocardial ischemia/reperfusion (MI/R) injury. Our present study investigated whether diabetes aggravated MI/R injury through inflammasome-mediated pyroptosis. Type 1 diabetic rat model was established intraperitoneal...

Diabetes aggravates myocardial ischemia-reperfusion (I/R) injury because of the combination effects changes in glucose and lipid energy metabolism, oxidative stress, systemic inflammatory response. Studies have indicated that I/R may coincide interact with sepsis inflammation. However, role LPS hypoxia/reoxygenation (H/R) cardiomyocytes under high conditions is still unclear. Our objective was to examine whether lipopolysaccharide (LPS) could aggravate glucose- (HG-) hypoxia/reoxygenation-...

Background and aims: Diabetic kidney is more sensitive to ischemia/reperfusion (I/R) injury, which associated with increased oxidative stress impaired nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling. Melatonin, a hormone that secreted the rhythm of light/dark cycle, has antioxidative effects in reducing acute injury (AKI). However, molecular mechanism melatonin protection against I/R state diabetes still unknown. In present study, we hypothesized attenuates...

The outbreak of coronavirus disease 2019 (COVID-19) has considerably burdened the healthcare system in Hubei Province, most severely affected region China. aim our study was to assess psychological effects COVID-19 epidemic on workers Hubei.A total 2737 were sampled using a two-dimensional code shared online between Mar 4 and 9, 2020. questionnaires consisted three elements: baseline characteristics, Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety Depression Scale (HADS). primary...

Protein kinase C (PKC)β2 is preferably overexpressed in the diabetic myocardium, which induces cardiomyocyte hypertrophy and contributes to cardiomyopathy, but underlying mechanisms are incompletely understood. Caveolae critical signal transduction of PKC isoforms cardiomyocytes. Caveolin (Cav)-3, cardiomyocyte-specific caveolar structural protein isoform, decreased heart. The current study determined whether PKCβ2 activation affects caveolae Cav-3 expression. Immunoprecipitation...

Long non-coding (lncRNA) MALAT1 can be increased by hypoxia or ischemic limbs. Also, downregulation of contributes to reduction cardiomyocyte apoptosis. However, the functional involvement in myocardial ischemia-reperfusion (I/R) injury has not been defined. This study investigated lncRNA-MALAT1 cardioprotective effects fentanyl. HL-1, a cardiac muscle cell line from AT-1 mouse atrial tumor lineage was pre-treated with fentanyl and generated model hypoxia-reoxygenation (H/R). Relative...

Patients with diabetes are more vulnerable to myocardial ischemia/reperfusion (MI/R) injury, which is associated excessive reactive oxygen species (ROS) generation and decreased antioxidant defense. Histone deacetylase 6 (HDAC6), a regulator of the protein peroxiredoxin 1 (Prdx1), several pathological conditions in cardiovascular system. This study investigated whether tubastatin A (TubA), highly selective HDAC6 inhibitor, could confer protective effect by modulating Prdx1 acetylation rat...

Susceptibility to myocardial ischemia-reperfusion (IR) injury in type-2 diabetes (T2DM) remains disputed, although studies have reported that ferroptosis is associated with IR injury. Nobiletin, a flavonoid isolated from citrus peels, an antioxidant possesses anti-inflammatory and anti-diabetic activities. However, it unknown whether nobiletin has any protective effects on susceptibility during T2DM rats via ferroptosis. To investigate the underlying mechanisms of T2DM, we induced model at...

Patients with diabetes are vulnerable to MI/R (myocardial ischaemia/reperfusion) injury, but not responsive IPostC (ischaemic post-conditioning) which activates PI3K (phosphoinositide 3-kinase)/Akt (also known as PKB or protein kinase B) and JAK2 (Janus 2)/STAT3 (signal transducer activator of transcription 3) pathways confer cardioprotection. We hypothesized that increased cardiac PTEN (phosphatase tensin homologue deleted on chromosome 10), a major negative regulator PI3K/Akt, is...

Increasing evidence indicates that neuroinflammatory and oxidative stress play two pivotal roles in cognitive impairment after surgery. Honokiol (HNK), as an activator of Sirtuin3 (SIRT3), has potential multiple biological functions. The aim these experiments is to evaluate the effects HNK on surgery/anesthesia-induced decline mice.Adult C57BL/6 mice received a laparotomy under sevoflurane anesthesia or SIRT3 inhibitor (3-TYP) treatment. Cognitive function locomotor activity were evaluated...

The potential mechanism of postoperative cognitive impairment is still largely unclear. activation NLRP3 inflammasome had been reported to be involved in neurodegenerative diseases, including change, and closely related mitochondrial ROS mitophagy. Honokiol (HNK) owns multiple organic protective effects. This study aimed at observing the neuroprotective effect HNK change examining role regulation mitophagy relationship between these effects mice induced by surgery/anesthesia. In this study,...

Diabetic hearts are more vulnerable to ischemia/reperfusion (I/R) injury and less responsive remifentanil preconditioning (RPC), but the underlying mechanisms incompletely understood. Caveolin-3 (Cav-3), dominant isoform of cardiomyocyte caveolae, is reduced in diabetic which oxidative stress increased. This study determined whether compromised RPC diabetes was an independent manifestation hyperglycemia-induced or linked impaired Cav-3 expression with associated signaling abnormality....

Abstract The circadian clock is closely related to the development of diabetes mellitus and cardiovascular disease, disruption exacerbates myocardial ischaemia/reperfusion injury (MI/RI). HDAC3 a key component negative feedback loop that controls expression pattern nuclear receptor Rev-erbα maintain stability genes such as BMAL1. However, mechanism by which HDAC3-orchestrated Rev-erbα/BMAL1 pathway increases MI/RI in its relationship with mitophagy have yet be elucidated. Here, we observed...

Type 2 diabetic hearts are more vulnerable to myocardial ischemia reperfusion (MIR) injury, which involves decreased mitophagy status with unknown mechanisms. MitoQ, a mitochondria-targeted antioxidant, has been shown have protection against injury through upregulating mitophagy. The aim of this study was investigate the effects MitoQ on myocardium during MIR in type diabetes (T2D). Herein, discovered that PINK1/Parkin downregulation suffered accompanied by reduced Treatment significantly...

Oxidative stress plays critical roles in the development of diabetic cardiovascular complications, including myocardial hypertrophy. The β isoform PKC (protein kinase C) is preferentially overexpressed myocardium subjects accompanied with increased activation pro-oxidant enzyme NADPH oxidase, which may exacerbate oxidative stress. We hypothesized that PKCβ a major upstream mediator diabetes and inhibition can attenuate hypertrophy dysfunction. Control or streptozotocin-induced rats were...

Patients with diabetes are prone to develop cardiac hypertrophy and more susceptible myocardial ischemia–reperfusion (I/R) injury, which concomitant hyperglycemia-induced oxidative stress impaired endothelial nitric oxide (NO) synthase (eNOS)/NO signaling. Caveolae critical in the transduction of eNOS/NO signaling cardiovascular system. Caveolin (Cav)-3, cardiomyocytes-specific caveolae structural protein, is decreased diabetic heart production reactive oxygen species increased. We...

(-)-Epigallocatechin gallate (EGCG) exerts multiple beneficial effects on cardiovascular performance. In this study, we aimed to examine the of EGCG diabetic cardiomyopathy during myocardial ischemia/reperfusion (I/R) injury. (100 mg/kg/day) was administered at week 6 for 2 weeks rats following induction type 1 diabetes by streptozotocin (STZ). At end 8, animals were subjected I/R The EGCG-elicited structural and functional analyzed. Additionally, (20 µM) 24 h cultured cardiac H9c2 cells...

Objective. Intestinal ischemia reperfusion (II/R) injury plays a critical role in remote organ dysfunction, such as lung injury, which is associated with nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. In the present study, we tested whether ginsenoside Rb1 attenuated II/R induced by Nrf2/HO-1 Methods. was male C57BL/6J mice 45 min of superior mesenteric artery (SMA) occlusion followed hours reperfusion. Ginsenoside administrated prior to or without...

Ischemia/reperfusion (I/R) is an inevitable pathophysiological process during heart transplantation, and ferroptosis important pathogenic mechanism. Unlike other modes of cell death, depends on the accumulation iron within oxidative degradation polyunsaturated fatty acids. Dysregulation this pathway has been linked to progression multiple pathological conditions, making it attractive target for therapeutic intervention. Therefore, study aims explore effect I/R transplantation. GEO2R was...

The hypermetabolic response associated with burns is characterized by skeletal muscle atrophy and an increased incidence of disability death. Significant remodeling the gut microbiota occurs after severe burn trauma. However, specific mechanisms which contribute to burn-induced remain unexplored. results showed that disruption exacerbated atrophy. Fecal metabolite analysis revealed perturbations, primarily within tryptophan (Trp) metabolic pathway. Animal models further demonstrated disorder...