A5075622190- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Nausea and vomiting management
- Tracheal and airway disorders
- Pain Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Inflammatory mediators and NSAID effects
- MicroRNA in disease regulation
- Health and Medical Research Impacts
- Pain Management and Opioid Use
- Cardiac electrophysiology and arrhythmias
- Cancer, Stress, Anesthesia, and Immune Response
- Pediatric Pain Management Techniques
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Spine and Intervertebral Disc Pathology
- Innovations in Medical Education
University of Hong Kong
2016-2025
Queen Mary Hospital
2015-2025
Chinese University of Hong Kong
2013-2024
UCLA Health
2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Hospital Base
2021
Duchess of Kent Children's Hospital
1994-2020
University Hospital Southampton NHS Foundation Trust
2019
University of Southampton
2019
The American Society of Anesthesiologists (ASA) physical status classification system has previously been shown to be inconsistently applied by anaesthetists. One hundred and sixty questionnaires were sent out all specialist anaesthetists in Hong Kong. Ten hypothetical patients, identical those a similar study undertaken 20 years ago, each with different types degrees disability described. Respondents asked about their country training type anaesthetic practice assign an ASA for patient....
Midazolam is the most commonly used premedication in children. It has been shown to be more effective than parental presence or placebo reducing anxiety and improving compliance at induction of anesthesia. Clonidine, an alpha(2) agonist, suggested as alternative. Dexmedetomidine a selective drug with favorable pharmacokinetic properties clonidine. We designed this prospective, randomized, double-blind, controlled trial evaluate whether intranasal dexmedetomidine oral midazolam for...
The alpha2-receptor agonist, dexmedetomidine, provides sedation with facilitated arousal and analgesia no respiratory depression. These properties render it potentially useful for anesthesia premedication, although parenteral administration is not practical in this setting. We designed study to evaluate the sedative, anxiolytic, analgesic, hemodynamic effects of dexmedetomidine administered intranasally healthy volunteers.Koch's design crossover trials (three-treatment two-period design) was...
Previous studies have shown that 1 μg.kg(-1) intranasal dexmedetomidine produces significant sedation in children aged between 2 and 12 years. This investigation was designed to evaluate the onset time. One hundred 1-12 years of ASA physical status 1-2 undergoing elective surgery were randomly allocated five groups. Patients groups A D received . Group E placebo (0.9% saline). Children from A, B, C, had intravenous cannulation attempted at 30, 45, 60, 75 45 min respectively after drug or...
Summary We compared sedation levels in children following administration of intranasal dexmedetomidine. One hundred and sixteen aged between 1 8 years were enrolled this prospective, randomised trial. Children assigned to receive either dexmedetomidine μg.kg −1 (Group 1) or 2 2). Thirty‐one (53%) patients from Group 38 (66%) satisfactorily sedated at the time anaesthetic induction. Logistic regression showed a significant interaction effect (p = 0.049), with odds ratio over estimated as 1.1...
Allopurinol (ALP) attenuates oxidative stress and diabetic cardiomyopathy (DCM), but the mechanism is unclear. Activation of nuclear factor erythroid 2-related 2 (Nrf2) following disassociation with its repressor Keap1 under can maintain inner redox homeostasis attenuate DCM concomitant attenuation autophagy. We postulated that ALP treatment may activate Nrf2 to mitigate autophagy over-activation consequently DCM. Streptozotocin-induced type 1 rats were untreated or treated (100 mg/kg/d) for...
Protein kinase C (PKC)β2 is preferably overexpressed in the diabetic myocardium, which induces cardiomyocyte hypertrophy and contributes to cardiomyopathy, but underlying mechanisms are incompletely understood. Caveolae critical signal transduction of PKC isoforms cardiomyocytes. Caveolin (Cav)-3, cardiomyocyte-specific caveolar structural protein isoform, decreased heart. The current study determined whether PKCβ2 activation affects caveolae Cav-3 expression. Immunoprecipitation...
Systemic inflammation induces neuroinflammation and cellular changes such as tau phosphorylation to impair cognitive function, including learning memory. This study uses a single model, laparotomy without any pathogen, characterize these their responses anti-inflammatory treatment in the intermediate term.In two-part experiment, wild-type C57BL/6N mice (male, 3 month old, 25 ± 2 g) were subjected sevoflurane anesthesia alone or laparotomy. Cognitive performance, systemic neuroinflammatory...
<h2>Abstract</h2><h3>Background</h3> Perioperative arterial blood pressure management is a physiologically complex challenge influenced by multiple factors. <h3>Methods</h3> A multidisciplinary, international working subgroup of the Third Quality Initiative (POQI) consensus meeting reviewed (patho)physiology and measurement as applied to perioperative medicine. We addressed predefined questions undertaking modified Delphi analysis, in which primary clinical research review articles were...
Opioid receptors mediate cardiac ischemic preconditioning. Remifentanil is a new, potent ultra-short-acting phenylpiperidine opioid used in high doses for anesthesia. The authors hypothesize that pretreatment with this drug confers cardioprotection.Male Sprague-Dawley rats were anesthetized and the chest was opened. All animals subjected to 30 min of occlusion left coronary artery 2 h reperfusion. Before 30-min occlusion, received either preconditioning by ischemia (ischemic preconditioning,...