A5021022035- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Renal function and acid-base balance
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Muscle and Compartmental Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Electrolyte and hormonal disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Mechanical Circulatory Support Devices
- Ion Transport and Channel Regulation
- Organ Transplantation Techniques and Outcomes
- Poisoning and overdose treatments
- Immune Response and Inflammation
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Abdominal Trauma and Injuries
- Intensive Care Unit Cognitive Disorders
- Trauma and Emergency Care Studies
- Cardiac Ischemia and Reperfusion
- Metabolism and Genetic Disorders
University of Pittsburgh Medical Center
2016-2025
University of Pittsburgh
2016-2025
King's College Hospital NHS Foundation Trust
2025
King's College London
2025
Guy's and St Thomas' NHS Foundation Trust
2025
Iridian Spectral Technologies (Canada)
2022-2024
National Institutes of Health
2015-2023
Children's Hospital of Pittsburgh
2017-2022
Pittsburg State University
2019-2022
Magee-Womens Hospital
2022
Abstract Introduction Acute kidney injury (AKI) is a complex disorder for which currently there no accepted definition. Having uniform standard diagnosing and classifying AKI would enhance our ability to manage these patients. Future clinical translational research in will require collaborative networks of investigators drawn from various disciplines, dissemination information via multidisciplinary joint conferences publications, improved translation knowledge pre-clinical research. We...
Although acute renal failure (ARF) is believed to be common in the setting of critical illness and associated with a high risk death, little known about its epidemiology outcome or how these vary different regions world.To determine period prevalence ARF intensive care unit (ICU) patients multiple countries; characterize differences etiology, severity, clinical practice; impact on patient outcomes.Prospective observational study ICU who either were treated replacement therapy (RRT) fulfilled...
Acute kidney injury (AKI) is a common and serious problem affecting millions causing death disability for many. In 2012, Kidney Disease: Improving Global Outcomes completed the first ever, international, multidisciplinary, clinical practice guideline AKI. The based on evidence review appraisal, covers AKI definition, risk assessment, evaluation, prevention, treatment. this we summarize key aspects of including definition staging AKI, as well evaluation nondialytic management....
In a single-center study published more than decade ago involving patients presenting to the emergency department with severe sepsis and septic shock, mortality was markedly lower among those who were treated according 6-hour protocol of early goal-directed therapy (EGDT), in which intravenous fluids, vasopressors, inotropes, blood transfusions adjusted reach central hemodynamic targets, receiving usual care. We conducted trial determine whether these findings generalizable all aspects necessary.
The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial.We randomly assigned and failure at least one nonrenal organ or sepsis to receive intensive less therapy. primary end point was death from any cause by day 60. In both study groups, hemodynamically stable underwent intermittent hemodialysis, unstable continuous venovenous hemodiafiltration sustained low-efficiency dialysis. Patients receiving the treatment strategy...
Abstract Introduction The lack of a standard definition for acute kidney injury has resulted in large variation the reported incidence and associated mortality. RIFLE, newly developed international consensus classification injury, defines three grades severity – risk (class R), I) failure F) but not yet been evaluated clinical series. Methods We performed retrospective cohort study, seven intensive care units single tertiary academic center, on 5,383 patients admitted during one year period...
Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely provide benefit. Identifying early markers damage has been difficult due the complex nature human AKI, in which multiple etiologies exist. The objective this study was identify validate novel biomarkers AKI.
Sepsis is a heterogeneous syndrome. Identification of distinct clinical phenotypes may allow more precise therapy and improve care.To derive sepsis from data, determine their reproducibility correlation with host-response biomarkers outcomes, assess the potential causal relationship results randomized trials (RCTs).Retrospective analysis data sets using statistical, machine learning, simulation tools. Phenotypes were derived among 20 189 total patients (16 552 unique patients) who met...
<h3>Importance</h3> Optimal timing of initiation renal replacement therapy (RRT) for severe acute kidney injury (AKI) but without life-threatening indications is still unknown. <h3>Objective</h3> To determine whether early RRT in patients who are critically ill with AKI reduces 90-day all-cause mortality. <h3>Design, Setting, and Participants</h3> Single-center randomized clinical trial 231 Kidney Disease: Improving Global Outcomes (KDIGO) stage 2 (≥2 times baseline or urinary output <0.5...
Sepsis is the most common cause of acute kidney injury (AKI) in critical illness, but there limited information on septic AKI. A prospective, observational study critically ill patients with and nonseptic AKI was performed from September 2000 to December 2001 at 54 hospitals 23 countries. total 1753 were enrolled. considered 833 (47.5%); predominant sources sepsis chest abdominal (54.3%). Septic associated greater aberrations hemodynamics laboratory parameters, severity higher need for...
Background: Severe sepsis is common and frequently fatal, community-acquired pneumonia (CAP) the leading cause.Although severe often attributed to uncontrolled unbalanced inflammation, evidence from humans with infection syndromes across breadth of disease lacking.In this study we describe systemic cytokine response determine if specific patterns, including balance proinflammatory anti-inflammatory markers, are associated death.Methods: This a cohort 1886 subjects hospitalized CAP through...
To assess the association of 0.9% saline use versus a calcium-free physiologically balanced crystalloid solution with major morbidity and clinical resource after abdominal surgery.0.9% saline, which results in hyperchloremic acidosis infusion, is frequently used to replace volume losses surgery.An observational study using Premier Perspective Comparative Database was performed evaluate adult patients undergoing open surgery who received either (30,994 patients) or (926 on day surgery. The...