A5048386803- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Liver Disease and Transplantation
- Muscle and Compartmental Disorders
- Poisoning and overdose treatments
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Potassium and Related Disorders
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Electrolyte and hormonal disorders
- Anesthesia and Sedative Agents
- Antibiotics Pharmacokinetics and Efficacy
- Aortic aneurysm repair treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Kidney Stones and Urolithiasis Treatments
- Central Venous Catheters and Hemodialysis
University of California, San Diego
2015-2025
Universidade de São Paulo
2012-2025
University of California San Diego Medical Center
2017-2023
University of San Simón
2018
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2009-2017
National Kidney Foundation
2014
Although acute renal failure (ARF) is believed to be common in the setting of critical illness and associated with a high risk death, little known about its epidemiology outcome or how these vary different regions world.To determine period prevalence ARF intensive care unit (ICU) patients multiple countries; characterize differences etiology, severity, clinical practice; impact on patient outcomes.Prospective observational study ICU who either were treated replacement therapy (RRT) fulfilled...
Sepsis is the most common cause of acute kidney injury (AKI) in critical illness, but there limited information on septic AKI. A prospective, observational study critically ill patients with and nonseptic AKI was performed from September 2000 to December 2001 at 54 hospitals 23 countries. total 1753 were enrolled. considered 833 (47.5%); predominant sources sepsis chest abdominal (54.3%). Septic associated greater aberrations hemodynamics laboratory parameters, severity higher need for...
<h3>Importance</h3> In the last decade, new biomarkers for acute kidney injury (AKI) have been identified and studied in clinical trials. Guidance is needed regarding how best to incorporate them into practice. <h3>Objective</h3> To develop recommendations on AKI based existing data expert consensus practicing clinicians researchers. <h3>Evidence Review</h3> At 23rd Acute Disease Quality Initiative meeting, a meeting of 23 international experts critical care, nephrology, related specialties,...
Abstract Introduction Serum creatinine concentration (sCr) is the marker used for diagnosing and staging acute kidney injury (AKI) in RIFLE AKIN classification systems, but influenced by several factors including its volume of distribution. We evaluated effect fluid accumulation on sCr to estimate severity AKI. Methods In 253 patients recruited from a prospective observational study critically-ill with AKI, we calculated cumulative balance computed fluid-adjusted reflecting distribution...
In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the classification and management of acute kidney injury (AKI). The was derived from evidence available through February 2011. Since then, new has emerged that important implications for clinical practice in diagnosing managing AKI. April 2019, KDIGO held controversies conference entitled Acute Injury with following goals: determine best practices areas uncertainty treating AKI; review key relevant literature...
Objective: According to recent research, diuretics may increase mortality in acute renal failure patients. The administration of such patients has been discouraged. Our objective was determine the impact on rate critically ill with failure. Design: Prospective, multiple-center, multinational epidemiologic study. Setting: Intensive care units from 54 centers and 23 countries. Patients: Patients were 1,743 consecutive who either treated replacement therapy or fulfilled predefined criteria for...
The incidence and prevalence of heart failure (HF) chronic kidney disease (CKD) are increasing, as such a better understanding the interface between both conditions is imperative for developing optimal strategies their detection, prevention, diagnosis, management. To this end, Kidney Disease: Improving Global Outcomes (KDIGO) convened an international, multidisciplinary Controversies Conference titled Heart Failure in CKD. Breakout group discussions included (i) HF with preserved ejection...
AKI is a global concern with high incidence among patients across acute care settings. associated significant clinical consequences and increased health costs. Preventive measures, as well rapid identification of AKI, have been shown to improve outcomes in small studies. Providing high-quality for or those at risk occurs continuum that starts the community level continues emergency department, hospital setting, after discharge from inpatient care. Improving quality provided these patients,...
Background. Acute kidney injury (AKI) is common in critically ill patients and associated with high morbidity mortality. Early identification of high-risk provides an opportunity to develop strategies for prevention, early diagnosis treatment AKI. Methods. We undertook this multicenter prospective cohort study validate a risk score predicting AKI admitted intensive care unit (ICU). Patients were screened predictor variables within 48 h ICU admission. Baseline acute factors recorded at the...
Objectives: To describe current practice for the discontinuation of continuous renal replacement therapy in a multinational setting and to identify variables associated with successful discontinuation. The approach discontinue may affect patient outcomes. However, there is lack information on how under what conditions discontinued. Design: Post hoc analysis prospective observational study. Setting: Fifty-four intensive care units 23 countries. Patients: Five hundred twenty-nine patients...
Using a large, international cohort, we sought to determine the effect of initial technique renal replacement therapy (RRT) on outcome acute failure (ARF) in intensive care unit (ICU). We enrolled 1218 patients treated with continuous RRT (CRRT) or intermittent (IRRT) for ARF 54 ICUs 23 countries. obtained demographic, biochemical and clinical data followed either death hospital discharge. Information was analyzed assess independent impact treatment choice survival recovery. Patients first...
Background. The RIFLE classification scheme for acute kidney injury (AKI) is based on relative changes in serum creatinine (SCr) and urine output. SCr criteria, therefore, require a pre-morbid baseline value. When unknown, current recommendations are to estimate by the MDRD equation. However, approach assumes glomerular filtration rate of ∼75 mL/min/1.73 m 2 . This method has not been validated. Methods. Data from Beginning Ending Supportive Therapy Kidney (BEST Kidney) study, prospective...
Background. The widespread use of RIFLE and AKIN classification systems for acute kidney injury (AKI) diagnosis staging has established the association between AKI severity adverse outcomes. However, as a result difficulties in measuring recording urine output every hour, few prospective studies have validated criterion stated these systems. We assessed hourly ICU patients using an automated accurate device to determine if changes flow volume could be sensitive marker AKI. Additionally, we...
Acute kidney injury (AKI) is a common but complex clinical syndrome with multiple etiologies. These etiologies target different sites and pathways within the kidney. Novel biomarkers of 'kidney damage' (which can be tubular or glomerular) used to diagnose AKI, even in absence an increase serum creatinine oliguria. damage combined function facilitate classification AKI. A comprehensive review literature was performed using published methodology Dialysis Quality Initiative (ADQI) working group...
Detection of acute kidney injury is undergoing a dynamic revolution biomarker technology allowing greater, earlier, and more accurate determination diagnosis, prognosis, with powerful implication for management. Biomarkers can be broadly considered as any measurable biologic entity or process that allows differentiation between normal function disease. The ADQI (Acute Dialysis Quality Initiative) had its Ninth Consensus Conference dedicated to synthesis formulation the existing literature on...
Objective: Several different severity scoring systems specific to acute renal failure have been proposed. However, most validation studies of these were conducted in a single center or small number centers, often the same ones used for their development. Therefore, it is not known whether such may be widely applied. Design: Prospective clinical investigation. Setting: Intensive care units. Patients: One thousand seven hundred and forty-two intensive unit patients with who either treated...
Studies examining dose of continuous renal replacement therapy (CRRT) and outcomes have yielded conflicting results. Most studies considered the prescribed as effluent rate represented by ml/kg per hour reported this volume a surrogate solute removal. Because filter fouling can reduce efficacy clearance, actual delivered may be substantially lower than observed rate.Data were examined from 52 critically ill patients with acute kidney injury (AKI) requiring dialysis. All treated predilution...