A5050533188- Acute Kidney Injury Research
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- T-cell and B-cell Immunology
- Organ Transplantation Techniques and Outcomes
- Cytomegalovirus and herpesvirus research
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Muscle and Compartmental Disorders
- Renal Diseases and Glomerulopathies
- Liver Disease and Transplantation
- Electrolyte and hormonal disorders
- Blood Pressure and Hypertension Studies
- Complement system in diseases
- Sepsis Diagnosis and Treatment
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Pharmacological Effects and Toxicity Studies
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Blood groups and transfusion
- Lanthanide and Transition Metal Complexes
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
University of Duisburg-Essen
2016-2025
Essen University Hospital
2016-2025
Krankenhaus vom Roten Kreuz
2024
Endokrinologikum
2024
University Hospital of Basel
2019
University of Lausanne
2019
University Hospital of Bern
2019
October 6 University
2016
Christie's
2016
Creative Commons
2016
In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the classification and management of acute kidney injury (AKI). The was derived from evidence available through February 2011. Since then, new has emerged that important implications for clinical practice in diagnosing managing AKI. April 2019, KDIGO held controversies conference entitled Acute Injury with following goals: determine best practices areas uncertainty treating AKI; review key relevant literature...
Kidney disease is an important public health problem. Both acute kidney injury (AKI) and chronic have been well defined classified, leading to improved research efforts subsequent management strategies recommendations. For those patients with abnormalities in function and/or structure who meet neither the definition of AKI nor disease, there remains a gap research, care, guidance. The term diseases disorders, abbreviated (AKD), has introduced as construct address this. To expand harmonize...
May 22nd marks the beginning of a Shiga-toxin-producing Escherichia coli (STEC) O104:H4 outbreak in Northern Germany. By its end on 27 July, it had claimed 53 deaths among 2987 STEC and 855 confirmed haemolytic–uraemic syndrome (HUS) cases. To describe short-term effectiveness best supportive care (BSC), therapeutic plasma exchange (TPE) TPE with eculizumab (TPE-Ecu) 631 patients suspected HUS treated 84 hospitals Germany, Sweden Netherlands using web-based registry DGfN (online since May)....
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has a major impact on transplant recipients, with mortality rates up to 20%. Therefore, the effect of established messenger RNA (mRNA)-based SARS-CoV-2 vaccines have be evaluated for solid organ patients (SOT) since they are known poor responses after vaccination. We investigated immune response via IgG detection in 23 renal recipients two doses mRNA-based vaccine BNT162b2 following standard protocol. antibody was once an...
Objectives The RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for disease 2019 (COVID-19). Cell entry mediated by the human angiotensin-converting enzyme II (ACE2). ACE2 and its close homolog I ( ACE ) are currently discussed candidate genes, in which single-nucleotide polymorphisms (SNPs) could alter binding or of SARS-CoV-2 enhance tissue damage lung other organs. This increase susceptibility infection severity COVID-19. Patients methods We performed...
Acute tubular necrosis (ATN) has high mortality, especially in patients who require renal replacement therapy (RRT). We prospectively studied the diagnostic accuracy of urinary excretion low-molecular-weight proteins and enzymes as predictors a need for RRT ATN.In 73 consecutive with initially nonoliguric ATN, we measured alpha(1)- beta(2)-microglobulin, cystatin C, retinol-binding protein, alpha-glutathione S-transferase, gamma-glutamyltransferase, lactate dehydrogenase,...
Background. Continuous venovenous haemofiltration (CVVH) in the intensive care setting requires anticoagulation to prevent clotting of extracorporeal circuit. Several protocols avoiding heparin and using regional citrate have been developed diminish bleeding risks. However, data from randomized trials comparing with systemic heparinization are very limited.
Functional and structural abnormalities in the renal microvasculature are important processes contributing to pathophysiology of ischemic acute kidney injury (AKI). In this study, we examine contribution endothelial cell loss via apoptosis on microvascular permeability rarefaction a mouse model AKI. Three-dimensional reconstructions networks obtained 24 h following demonstrate an intact monolayer areas increased permeability. A 45% decrease density was observed 4 wk after injury. Examination...
Reimbursement for chronic dialysis consumes a substantial portion of healthcare costs relatively small proportion the total population. Each country has unique reimbursement system that attempts to control rising costs. Thus, comparing systems between countries might be helpful find solutions minimize society without jeopardizing quality treatment and outcomes. We conducted survey seven compare crude various modalities evaluated additional factors, such as inclusion drugs or physician...
Purpose One of the key problems in drug therapy patients with chronic conditions is adherence. In 2010 initiative iNephro was launched (www.inephro.de). A software to support regular and correct intake developed for a smartphone platform (iOS). The study investigated whether how users deployed such an application. Methods Together cooperating partners mobile application "Medikamentenplan" ("Medication Plan") developed. Users are able keep alter list their medication. memory function supports...
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare but life-threatening condition. In 2018, the nanobody caplacizumab was approved for treatment of adults experiencing an acute episode aTTP, in conjunction with plasma exchange (PEX) and immunosuppression minimum 30 days after stopping daily PEX. We performed retrospective, observational analysis on use 60 patients from 29 medical centers Germany during disease management. Caplacizumab led to rapid normalization platelet count...
mRNA-based SARS-CoV-2 vaccines offer a preventive strategy against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections that is of interest in the care patients on hemodialysis (HDP). We measured humoral immune responses 72 HDP after standard vaccination with two doses vaccine BNT162b2 (Pfizer-BioNTech). Antibody were evaluated an anti-SARS-CoV-2 IgG ChemiLuminescent ImmunoAssay (CLIA) weeks second dose. In addition, was determined control 16 healthy healthcare workers...
The transmembrane serine protease 2 (TMPRSS2) is the major host that enables entry of severe acute respiratory syndrome coronavirus type (SARS-CoV-2) into cells by spike (S) protein priming. Single nucleotide polymorphisms (SNPs) in gene TMPRSS2 have been associated with susceptibility to and severity H1N1 or H1N9 influenza A virus infections. Functional variants may influence SARS-CoV-2 infection risk Coronavirus disease 2019 (COVID-19) as well. Therefore, we analyzed role SNPs a German...
Serum cystatin C, a cysteine proteinase inhibitor, has been proposed as marker of glomerular filtration rate (GFR). serum creatinine and clearance were measured in 226 patients with various nephropathies, covering the entire range renal function, to evaluate efficacy C screening test detect reduced comparison creatinine. Subgroups 53 26 tubular impairment compared assess whether performed differently either or impairment. Cystatin detected higher sensitivity (97 vs. 83%), negative predictive...
<i>Background:</i> Arteriosclerosis and cardiovascular disease are strongly associated with vascular calcification. Hyperphosphatemia is an essential risk factor for increased End-stage renal (ESRD) patients could serve as in vivo model accelerated This study focuses on the most likely protective effects of magnesium ion (Mg<sup>2+</sup>) phosphate-induced calcification ex vivo/in vitro. Furthermore, plasma Mg<sup>2+</sup> concentrations ESRD healthy...
Subcutaneous administration of Eprex® (epoetin alfa) in patients with chronic kidney disease (CKD) was contraindicated the European Union between 2002 and 2006 after increased reports anti-erythropoietin antibody-mediated pure red cell aplasia (PRCA). The Prospective Immunogenicity Surveillance Registry (PRIMS) conducted to estimate incidence PRCA subcutaneous a new coated-stopper syringe presentation compare this NeoRecormon® beta) Aranesp® (darbepoetin alfa). PRIMS multicentre,...
Medication adherence is crucial for success in the management of patients with chronic conditions. This study analyzes whether a mobile application on tablet aimed at supporting drug intake and vital sign parameter documentation affects elderly patients. Patients coronary heart disease no prior knowledge computers were recruited. They received personal introduction to Plan, installed an Apple iPad. The was conducted using crossover design 3 sequences: initial phase, interventional phase (28...
An increased bleeding risk is reported for patients with end-stage renal disease. This study aims to analyze, whether can be assessed by global tests of hemostasis. Standard laboratory and an extended evaluation hemostasis rotational thromboelastometry, platelet function analyzer (PFA) multiple electrode aggregometry as well thrombin generation assays measurement fibrinolytic potential were performed in 20 on hemodialysis, 10 peritoneal dialysis, chronic kidney disease stage G5 (CKD5)...