A5016122611- Cardiac, Anesthesia and Surgical Outcomes
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Chronic Kidney Disease and Diabetes
- Anesthesia and Pain Management
- Dialysis and Renal Disease Management
- Enhanced Recovery After Surgery
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Electrolyte and hormonal disorders
- Heart Failure Treatment and Management
- Anesthesia and Neurotoxicity Research
- Blood Pressure and Hypertension Studies
- Cardiac and Coronary Surgery Techniques
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Pain Management and Opioid Use
- Pediatric Pain Management Techniques
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
Cleveland Clinic
2021-2025
University of Tennessee Health Science Center
2022-2025
Cleveland Clinic Lerner College of Medicine
2025
Case Western Reserve University
2025
Imperial College London
2007-2024
Clinical Trial Investigators
2024
Glasgow Royal Infirmary
1982-2023
Missoula County Public Schools
2023
Robert Jones and Agnes Hunt Orthopaedic Hospital
2023
Neurological Surgery
2014-2023
Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely provide benefit. Identifying early markers damage has been difficult due the complex nature human AKI, in which multiple etiologies exist. The objective this study was identify validate novel biomarkers AKI.
Both balanced crystalloids and saline are used for intravenous fluid administration in critically ill adults, but it is not known which results better clinical outcomes.
Comparative clinical effects of balanced crystalloids and saline are uncertain, particularly in noncritically ill patients cared for outside an intensive care unit (ICU).
To assess the association of 0.9% saline use versus a calcium-free physiologically balanced crystalloid solution with major morbidity and clinical resource after abdominal surgery.0.9% saline, which results in hyperchloremic acidosis infusion, is frequently used to replace volume losses surgery.An observational study using Premier Perspective Comparative Database was performed evaluate adult patients undergoing open surgery who received either (30,994 patients) or (926 on day surgery. The...
<h3>Importance</h3> In the last decade, new biomarkers for acute kidney injury (AKI) have been identified and studied in clinical trials. Guidance is needed regarding how best to incorporate them into practice. <h3>Objective</h3> To develop recommendations on AKI based existing data expert consensus practicing clinicians researchers. <h3>Evidence Review</h3> At 23rd Acute Disease Quality Initiative meeting, a meeting of 23 international experts critical care, nephrology, related specialties,...
Severity of AKI is determined by the magnitude increase in serum creatinine level or decrease urine output. However, patients manifesting both oliguria and azotemia those which these impairments are persistent more likely to have worse disease. Thus, we investigated relationship severity duration across output domains with risk for RRT likelihood renal recovery survival using a large, academic medical center database critically ill patients. We analyzed electronic records from 32,045 treated...
Rationale: We recently reported two novel biomarkers for acute kidney injury (AKI), tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7), both related to G1 cell cycle arrest.Objectives: now validate a clinical test urinary [TIMP-2]·[IGFBP7] at high-sensitivity cutoff greater than 0.3 AKI risk stratification in diverse population critically ill patients.Methods: conducted prospective multicenter study 420 patients. The primary analysis was...
Despite the importance of blood flow on brainstem control respiratory and autonomic function, little is known about regional cerebral (CBF) during changes in arterial gases.We quantified: (1) anterior posterior CBF reactivity through a wide range steady-state partial pressures CO2 (PaCO2) O2 (PaO2) blood, (2) determined if internal carotid artery (ICA) vertebral (VA) change diameter same range.We used near-concurrent vascular ultrasound measures ICA VA, velocity their downstream arteries...
Objective: Isotonic saline is the most commonly used crystalloid in ICU, but recent evidence suggests that balanced fluids like Lactated Ringer’s solution may be preferable. We examined association between choice of crystalloids and in-hospital mortality during resuscitation critically ill adults with sepsis. Design: A retrospective cohort study patients admitted sepsis, not undergoing any surgical procedures, treated an ICU by hospital day 2. propensity score matching to control for...
In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the classification and management of acute kidney injury (AKI). The was derived from evidence available through February 2011. Since then, new has emerged that important implications for clinical practice in diagnosing managing AKI. April 2019, KDIGO held controversies conference entitled Acute Injury with following goals: determine best practices areas uncertainty treating AKI; review key relevant literature...
In the setting of early acute kidney injury (AKI), no test has been shown to definitively predict progression more severe stages.We investigated ability a furosemide stress (FST) (one-time dose 1.0 or 1.5 mg/kg depending on prior furosemide-exposure) development AKIN Stage-III in 2 cohorts critically ill subjects with AKI. Cohort 1 was retrospective cohort who received FST AKI patients as part Southern Network. prospective multicenter group their AKI.We studied 77 subjects; 23 from and 54 2;...
Kidney disease is an important public health problem. Both acute kidney injury (AKI) and chronic have been well defined classified, leading to improved research efforts subsequent management strategies recommendations. For those patients with abnormalities in function and/or structure who meet neither the definition of AKI nor disease, there remains a gap research, care, guidance. The term diseases disorders, abbreviated (AKD), has introduced as construct address this. To expand harmonize...
AKI is associated with major adverse kidney events (MAKE): death, new dialysis, and worsened renal function. CKD (arising from function) a higher risk of cardiac (MACE): myocardial infarction (MI), stroke, heart failure. Therefore, the study hypothesis was that veterans who develop during hospitalization for an MI would be at subsequent MACE MAKE.Patients in Veterans Affairs (VA) database had discharge diagnosis International Classification Diseases, Ninth Revision, code 584.xx (AKI) or...