A5082190633- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Cardiac, Anesthesia and Surgical Outcomes
- Muscle and Compartmental Disorders
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Electrolyte and hormonal disorders
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Antibiotics Pharmacokinetics and Efficacy
- Chronic Kidney Disease and Diabetes
- Pancreatitis Pathology and Treatment
- Airway Management and Intubation Techniques
- COVID-19 Clinical Research Studies
- Clinical Nutrition and Gastroenterology
- Liver Disease and Transplantation
- Blood Pressure and Hypertension Studies
- Antibiotic Resistance in Bacteria
- Anesthesia and Sedative Agents
- Ion Transport and Channel Regulation
- Anesthesia and Pain Management
Centre Hospitalier Universitaire de Bordeaux
2015-2024
Université de Bordeaux
2011-2024
Hôpital Cardiologique du Haut-Lévêque
2011-2023
Société de Réanimation de Langue Française
2022
Hôpital Saint Roch
2017
Intensive Care Foundation
2015
Imation (United States)
2014
Atrium Medisch Centrum Parkstad
2006-2008
Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely provide benefit. Identifying early markers damage has been difficult due the complex nature human AKI, in which multiple etiologies exist. The objective this study was identify validate novel biomarkers AKI.
To test whether the polymyxin B hemoperfusion (PMX HP) fiber column reduces mortality and organ failure in peritonitis-induced septic shock (SS) from abdominal infections. Prospective, multicenter, randomized controlled trial 18 French intensive care units October 2010 to March 2013, enrolling 243 patients with SS within 12 h after emergency surgery for peritonitis related perforation. The PMX HP group received conventional therapy plus two sessions of HP. Primary outcome was on day 28;...
Before surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme or angiotensin receptor blockers) is unknown. The lack of evidence leads to conflicting guidelines.
Background and objectives Prompt recognition of severe renal impairment could improve the early management critically ill patients. We compared value kinetic eGFR, plasma neutrophil gelatinase–associated lipocalin (NGAL), urine tissue inhibitor metalloproteinase-2 insulin-like growth factor–binding protein 7 ([TIMP-2]*[IGFBP7]) in predicting short-term recovery from AKI major adverse kidney events. Design, setting, participants, & measurements During 6-month study period, 245 patients were...
Coronavirus disease 2019 (COVID-19)-associated acute kidney injury (AKI) frequency, severity and characterization in critically ill patients has not been reported.
To examine the performance of urinary biomarker panel tissue inhibitor metalloproteinase-2 and insulin-like growth factor-binding protein 7 in patients with sepsis at ICU admission. investigate effect nonrenal organ dysfunction on this population.In ancillary analysis, we included who were enrolled either two trials including 39 ICUs across Europe North America. The primary endpoint was moderate-severe acute kidney injury (equivalent to Kidney Disease Improving Global Outcome stage 2-3)...
The world is currently facing an unprecedented healthcare crisis caused by the COVID-19 pandemic. objective of these guidelines to produce a framework facilitate partial and gradual resumption intervention activity in context group has endeavoured minimum number recommendations highlight strengths be retained 7 predefined areas: (1) protection staff patients; (2) benefit/risk patient information; (3) preoperative assessment decision on intervention; (4) modalities preanaesthesia...
The purpose of this study was to evaluate the effect high volume continuous venovenous hemofiltration (HVCVVH) on hemodynamic and outcome in patients with septic shock. primary end point mortality at 28 days. Study design a prospective case series, setting 12 bed intensive care unit university hospital. A total 24 consecutive shock were included, dysfunction more than two organs. All treated by HVCVVH ultrafiltration rate between 40 ml · kg−1 hr−1 60 for 96 hours. In all patients, increase...
Sepsis-induced acute kidney injury (SAKI) remains an important challenge in critical care medicine. We reviewed current available evidence on prevention and treatment of SAKI with focus some recent advances developments. Prevention starts early ample fluid resuscitation preferentially crystalloid solutions. Balanced crystalloids have no proven superior benefit. Renal function can be evaluated by measuring lactate clearance rate, renal Doppler, or central venous oxygenation monitoring....
Objective: Recent preclinical and clinical data suggest that thoracic epidural analgesia, a technique primarily aimed at decreasing pain, might exert anti-inflammatory effects, enhance splanchnic pancreatic blood flow during acute pancreatitis; however, the influence of analgesia on mortality remains under investigated in this setting. This study was therefore designed to assess impact ICU patients with pancreatitis. Design: Multicenter retrospective, observational, cohort study. Setting:...
Acute kidney injury requiring renal replacement therapy is a major concern in ICUs. Initial modality, continuous or intermittent hemodialysis, may impact recovery. The aim of this study was to assess the influence initial modality on recovery at hospital discharge.Retrospective cohort all ICU stays from January 1, 2010, December 31, 2013, with "renal for acute injury" code using French discharge database.Two hundred ninety-one ICUs France.A total 1,031,120 stays: 58,635 and 25,750 included...