A5062942302- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Ultrasound in Clinical Applications
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Enhanced Recovery After Surgery
- COVID-19 and Mental Health
- Anesthesia and Pain Management
- Climate Change and Health Impacts
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Pelvic and Acetabular Injuries
- Mechanical Circulatory Support Devices
- Cardiovascular Syncope and Autonomic Disorders
- Trauma and Emergency Care Studies
- Pregnancy-related medical research
- Family and Patient Care in Intensive Care Units
- Nausea and vomiting management
- Trauma Management and Diagnosis
- Cardiac electrophysiology and arrhythmias
Hôpital Nord
2014-2024
Aix-Marseille Université
2017-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023-2024
Assistance Publique Hôpitaux de Marseille
2017-2024
Hôpital de la Conception
2014-2024
Inserm
2022-2024
Lyon Genou Centre Albert Trillat
2024
Johns Hopkins Hospital
2024
Hôpital de la Timone
2022-2024
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2023
Perioperative hypotension is associated with an increase in postoperative morbidity and mortality, but the appropriate management strategy remains uncertain.To evaluate whether individualized blood pressure tailored to individual patient physiology could reduce organ dysfunction.The Intraoperative Norepinephrine Control Arterial Pressure (INPRESS) study was a multicenter, randomized, parallel-group clinical trial conducted 9 French university nonuniversity hospitals. Adult patients (n = 298)...
Summary Global warming is a major public health concern. Volatile anaesthetics are greenhouse gases that increase the carbon footprint of healthcare. Modelling studies indicate total intravenous anaesthesia less intensive than volatile anaesthesia, with equivalent quality care. In this observational study, we aimed to apply findings previous modelling compare per general anaesthetic an exclusive TIVA strategy vs. mixed TIVA‐volatile strategy. This comparative retrospective study was...
Before surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme or angiotensin receptor blockers) is unknown. The lack of evidence leads to conflicting guidelines.
Abstract Background Rapid response teams are intended to improve early diagnosis and intervention in ward patients who develop acute respiratory or circulatory failure. A management protocol including the use of a handheld ultrasound device for immediate point-of-care (POCUS) examination at bedside may team performance. The main objective study was assess impact implementing such POCUS-guided on proportion adequate diagnoses two groups. Secondary endpoints included time treatment patient...
Preoperative COVID-19 has been associated with excess postoperative morbi-mortality. Consequently, guidelines were developed that recommended the postponement of surgery for at least 7 weeks after infection. We hypothesised vaccination against SARS-CoV-2 and large predominance Omicron variant attenuated effect a preoperative on occurrence respiratory morbidity.We conducted prospective cohort study in 41 French centres between 15 March 30 May 2022 (ClinicalTrials NCT05336110), aimed comparing...
In minimally invasive thoracic surgery, paravertebral block (PVB) using ultrasound (US)-guided technique is an efficient postoperative analgesia. However, it operator-dependent process depending on experience and local resources. Because pain-control failure highly detrimental, surgeons may consider other locoregional analgesic options.
In solid cancer surgery, oxidative stress (OS) is of particular interest because both the malignancy itself and surgical intervention are major contributors to modulation OS levels. This study aimed investigate effects surgery on Because often accompanied by intense cell death, specifically focused pathway leading uric acid formation, (i.e. adenosine deaminase (ADA) xanthine oxidase (XO). Ische-mia-modified albumin (IMA), a recognized marker stress, plasma redox poten-tial (RP) were also...
Abstract Background Data about critically ill metastatic cancer patients functional outcome after unplanned admission to the ICU are scarce. The aim of this study was assess factors associated with 90-day return home and 1-year survival in population. Study design methods A multicenter retrospective included all consecutive admitted for reason between 2017 2020. Results Among 253 patients, mainly lung cancer, 94 (37.2%) could on day 90. One-year rate 28.5%. Performance status 0 or 1 (OR,...
Purpose: To compare characteristics and outcome in children undergoing extracorporeal life support initiated an center or at the patient’s bedside a local hospital, by means of mobile cardiorespiratory assistance unit. Methods: A retrospective study single PICU during 6 years. Extracorporeal was started either our (control group) hospital (mobile unit group). The data collected were demographics, markers preextracorporeal condition, outcome. Results: One hundred twenty-six underwent support,...
Background An association was reported between the left ventricular longitudinal strain (LV-LS) and preload. LV-LS reflects cardiac function curve as it is ratio of shortening over diastolic dimension. The aim this study to determine sensitivity specificity variations after a passive leg raising (PLR) maneuver predict fluid responsiveness in intensive care unit (ICU) patients with acute circulatory failure (ACF). Methods Patients ACF were prospectively included. Preload-dependency defined...
Physiotherapy is a major cornerstone of enhanced rehabilitation after surgery (ERAS) and reduces the development atelectasis thoracic surgery. By initiating physiotherapy in post-anaesthesia care unit (PACU), aim was to evaluate whether ultra-early initiation (in first hour following tracheal extubation) would improve outcomes patients undergoing elective
Surgical antimicrobial prophylaxis (SAP) is supported by evidence-based guidelines. Nevertheless, SAP guidelines do not cover all clinical scenarios. To our knowledge, no information available regarding in the critically ill patients. We designed a retrospective, observational and preliminary study which objective was to describe professional practices intensive care unit (ICU) patients requiring SAP.All admitted for more than 48 h ICU surgery were retrospectively included from January 1st...
BACKGROUND Stress due to surgical trauma decreases postoperative lymphocyte counts (LCs), potentially favouring the occurrence of infections (PIs). OBJECTIVES We aimed determine whether lymphopaenia following thoracic or gastrointestinal cancer surgery is an independent risk factor for PIs and identify modifiable factors related anaesthesia procedures that might affect its occurrence. STUDY DESIGN The EVALYMPH study was a prospective, multicentre cohort with 30-day patient follow-up....
To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 to determine 90-day mortality after ICU admission associated risk factors.This observational retrospective study was conducted in six (ICUs) three university hospitals Marseille, France. Between 10 March May 2020, all adult admitted SARS-CoV-2 respiratory failure were eligible for inclusion. The statistical analysis focused on the mechanically ventilated patients....
Abstract Background Current guidelines recommend using antifungals for selected patients with health care-associated intra-abdominal infection (HC-IAI), but this recommendation is based on a weak evidence. This study aimed to assess the association between early empirical use of and outcomes in intensive care unit (ICU) adult requiring re-intervention after abdominal surgery. Methods A retrospective, multicentre cohort overlap propensity score weighting was conducted three ICUs located...