A5069955707- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Nausea and vomiting management
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Abdominal Surgery and Complications
- Cardiac Ischemia and Reperfusion
- Long-Term Effects of COVID-19
- Pediatric Pain Management Techniques
- Cardiac Arrest and Resuscitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Anesthesia and Sedative Agents
- Thermal Regulation in Medicine
- Climate Change and Health Impacts
- Total Knee Arthroplasty Outcomes
- COVID-19 Clinical Research Studies
- Thermoregulation and physiological responses
- Pain Management and Placebo Effect
- Enhanced Recovery After Surgery
- Acupuncture Treatment Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hip and Femur Fractures
- Blood Pressure and Hypertension Studies
- Trauma and Emergency Care Studies
- Bone fractures and treatments
Hôpital d'Hautepierre
2012-2025
Mitochondrie, stress oxydant et protection musculaire
2013-2025
Clinical Trial Investigators
2025
Hôpitaux Universitaires de Strasbourg
2011-2024
Université de Strasbourg
2011-2020
Stony Brook Medicine
2017-2020
Collaborative Group (United States)
2020
Institut de Chirurgie Guidée par l'Image
2015-2020
Stony Brook University
2018
Philippe Foundation
2018
Before surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme or angiotensin receptor blockers) is unknown. The lack of evidence leads to conflicting guidelines.
Our aim was to evaluate a fluorescence-based enhanced-reality system assess intestinal viability in laparoscopic mesenteric ischemia model.A small bowel loop exposed, and 3 4 vessels were clipped 6 pigs. Indocyanine green (ICG) administered intravenously 15 minutes later. The illuminated with an incoherent light source laparoscope (D-light-P, KarlStorz). ICG fluorescence signal analyzed Ad Hoc imaging software (VR-RENDER), which provides digital perfusion cartography that superimposed the...
<h3>Importance</h3> It is not known if use of colloid solutions containing hydroxyethyl starch (HES) to correct for intravascular deficits in high-risk surgical patients either effective or safe. <h3>Objective</h3> To evaluate the effect HES 130/0.4 compared with 0.9% saline volume expansion on mortality and postoperative complications after major abdominal surgery. <h3>Design, Setting, Participants</h3> Multicenter, double-blind, parallel-group, randomized clinical trial 775 adult at...
Early and accurate detection of severe hemorrhage is critical for a timely trigger massive transfusion (MT). Hemodynamic indices combining heart rate (HR) either systolic (shock index [SI]) or pulse pressure (PP) (PP/HR ratio) have been shown to track blood loss during hemorrhage. The present study assessed the accuracy prehospital SI PP/HR ratio predict subsequent MT, using gray-zone approach.This was retrospective analysis (January 1, 2009, December 31, 2011) prospectively developed trauma...
Background/Objectives: Acute respiratory distress syndrome (ARDS) is a life-threatening condition that frequently complicates high-risk cardiac surgery. We evaluated the circulating levels and transpulmonary gradient of intracellular proteins in patients at risk developing ARDS after surgery using large scale-proteomics. Methods: enrolled sixteen undergoing surgery, followed by planned ICU admission. Circulating were measured onset surgical procedure, admission (H0), 24 h (H24) blood samples...
In Brief BACKGROUND: Studies evaluating intraperitoneal local anesthetic instillation for pain relief after laparoscopic procedures have reported conflicting results. this randomized, double-blind study we assessed the effects of nebulization on cholecystectomy. METHODS: Patients undergoing elective cholecystectomy were randomly assigned to receive either ropivacaine 0.5%, 20 mL induction pneumoperitoneum, or 1%, 3 before and surgery. Anesthetic surgical techniques standardized. Degree at...
To examine the incidence of Escherichia coli O157:H7 enteric infections in United States and to evaluate vehicles transmission for sporadic cases, we conducted a one-year, population-based study at large health maintenance organization (HMO) Puget Sound area Washington State. All stool specimens submitted culture HMO laboratory were screened E O157:H7; organism was identified 25 (0.4%) 6485 specimens. patients with had diarrhea; 24 (96%) bloody diarrhea. Exposure histories demonstrated that...
Strip-based handheld devices can measure lactatemia on capillary blood obtained by needle puncturing. We aimed to assess the kinetic of bowel lactates, metabolomics profiling, and mitochondria respiratory rate in a prolonged model hypoperfusion.In 6 pigs, 3- 4-cm ischemic segment was created small loops (total = 36 loops) clamping vascular supply, for duration 1 hours. Hourly, 5 samples were puncturing serosa, lactates measured using analyzer. Samples made at following regions interest...
Early hip fracture surgery is recommended to decrease mortality, however the impact of a delay in due previous treatment with direct oral anticoagulants (DOA) unknown. Our objective was determine if early surgery, defined as within 48 h hospital admission associated decreased postoperative mortality. We tested hypothesis that beneficial regard for mortality patients treated anticoagulants.Retrospective cohort study French University Hospital including patient admitted Hip fracture. The main...
Investigation of the clinical reasoning skills experienced clinicians provides insight into decision-making in practice physiotherapy. The purpose present study was to analyse an physiotherapist during her assessment and treatment clients with low back pain.Deconstruction physiotherapist's process accomplished through observation encounters between each six patient subjects. Reconstruction analysis performed retrospective interviews reflective encounter.A working model created from...
The death of a simulated patient is controversial. Some educators feel that having manikin die prejudicial to learning; others it way better preparing students for these situations. Perceived self-efficacy (PSE) reflects person's perception their ability carry out task. A high PSE necessary manage task efficiently. In this study, we measured the impact on medical students' perceived concerning cope with situation cardiac arrest. We carried single-centre, observational, prospective study....
Abstract Background Acute respiratory distress syndrome continues to drive significant morbidity and mortality after severe trauma. The incidence of trauma-induced, moderate-to-severe hypoxaemia, according the Berlin definition, could be as high 45%. Its pathophysiology includes release damage-associated molecular patterns (DAMPs), which propagate tissue injuries by triggering neutrophil extracellular traps (NETs). NETs include a DNA backbone coated with cytoplasmic proteins, pulmonary...
Abstract Standards are needed to control the quality of lungs from nonheart‐beating donors as potential grafts. This was here assessed using metabolomics 1 H high‐resolution magic angle spinning NMR spectroscopy. Selective perfusion porcine bilung block set up 30 min after cardiac arrest with cold Perfadex ® . Lung alterations were analyzed at 3, 6, and 8 h ischemia compared baseline nonperfused lung. Metabolomics analysis lung biopsies allowed identification 35 metabolites. Levels majority...
BACKGROUND Acupressure therapy is associated with favourable efficacies on postoperative nausea, pain and sleep disturbance, although the quality of evidence generally low. No randomised clinical trial has yet assessed effect acupressure recovery (QoR). OBJECTIVE The objective was to study efficacy patient-reported recovery. DESIGN We conducted a single centre, three-group, blind, controlled, pragmatic assessing PC6, LI4 HT7 acupoints. PATIENTS Postoperative patients expected stay in...
Background: Intraoperative hypotension is common in patients having non-cardiac surgery and associated with postoperative acute myocardial injury, kidney mortality. Avoiding intraoperative a complex task for anesthesiologists. Using artificial intelligence to predict from clinical hemodynamic data an innovative intriguing approach. The AcumenTM Hypotension Prediction Index (HPI) software (Edwards Lifesciences; Irvine, CA, USA) was developed using intelligence—specifically machine...
Opioid administration is particularly challenging in the perioperative period. Computerized-based Clinical Decision Support Systems (CDSS) are a promising innovation that might improve pain control. We report development and feasibility validation of knowledge-based CDSS aiming at optimizing management pain, postoperative nausea vomiting (PONV), laxative medications. This novel uses patient adaptive testing through smartphone display, literature-based rules, individual medical prescriptions...