Martine Ferrandière
A5107984940- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Hemoglobinopathies and Related Disorders
- Rabies epidemiology and control
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Hemodynamic Monitoring and Therapy
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Nosocomial Infections in ICU
- Antifungal resistance and susceptibility
- Inhalation and Respiratory Drug Delivery
- Microbial infections and disease research
- Poisoning and overdose treatments
- Liver Disease Diagnosis and Treatment
- Genital Health and Disease
- Renal Transplantation Outcomes and Treatments
Clinical Trial Investigators
2025
Centre Hospitalier Universitaire de Tours
2014-2024
Université de Tours
2003-2024
Inserm
2002-2023
Université de Strasbourg
2023
Research Network (United States)
2023
French Clinical Research Infrastructure Network
2023
Université de Bourgogne
2023
Cerebral Palsy Research Network
2023
Centre Hospitalier Universitaire de Nantes
2022
To test whether the polymyxin B hemoperfusion (PMX HP) fiber column reduces mortality and organ failure in peritonitis-induced septic shock (SS) from abdominal infections. Prospective, multicenter, randomized controlled trial 18 French intensive care units October 2010 to March 2013, enrolling 243 patients with SS within 12 h after emergency surgery for peritonitis related perforation. The PMX HP group received conventional therapy plus two sessions of HP. Primary outcome was on day 28;...
It has not been established whether noninvasive ventilation (NIV) reduces the need for invasive mechanical in patients who develop hypoxemic acute respiratory failure after abdominal surgery.To evaluate improves outcomes among developing surgery.Multicenter, randomized, parallel-group clinical trial conducted between May 2013 and September 2014 20 French intensive care units 293 had undergone surgery developed (partial oxygen pressure <60 mm Hg or saturation [SpO2] ≤90% when breathing room...
BackgroundWhether preventive inhaled antibiotics may reduce the incidence of ventilator-associated pneumonia is unclear.MethodsIn this investigator-initiated, multicenter, double-blind, randomized, controlled, superiority trial, we assigned critically ill adults who had been undergoing invasive mechanical ventilation for at least 72 hours to receive amikacin a dose 20 mg per kilogram ideal body weight once daily or placebo 3 days. The primary outcome was first episode during 28 days...
Abstract Background Anemia is a significant problem in patients on ICU. Its commonest cause, iron deficiency (ID), difficult to diagnose the context of inflammation. Hepcidin new marker ID. We aimed assess whether hepcidin levels would accurately guide treatment ID critically ill anemic after prolonged ICU stay and affect post-ICU outcomes. Methods In controlled, single-blinded, multicenter study, (WHO definition) with an ≥ 5 days were randomized when discharge was expected either...
Over a 5-month period, four liver transplant patients at single hospital were diagnosed with Pneumocystis jirovecii pneumonia (PCP). This unusually high incidence was investigated using molecular genotyping. Bronchoalveolar lavage fluids (BALF) obtained from the recipients PCP processed for multilocus sequence typing (MLST) three loci (SOD, mt26s, and CYB). Twenty-four other BALF samples, which positive P. collected 24 epidemiologically unrelated clinical signs of PCP, studied in parallel by...
The objective of this study was to characterize the pharmacokinetics unbound and total concentrations daptomycin in infected ICU patients with various degrees renal impairment. From these results, probability attaining antimicrobial efficacy risks toxicity were assessed.Twenty-four functions requiring treatment complicated skin soft-tissue infections, bacteraemia, or endocarditis recruited. Daptomycin (Cubicin®) at 10 mg/kg administered every 24 h for creatinine clearance (CLCR) ≥30 mL/min...
Human neutrophil elastase (HNE) has long been linked to the pathology of a variety inflammatory diseases and therefore is potential target for therapeutic intervention. At least two other serine proteases, proteinase 3 (Pr3) cathepsin G, are stored within same primary granules as HNE released from cell at time sites. Pr3 structurally functionally very similar, no substrate currently available that preferentially cleaved by rather than HNE. Discrimination between these proteases first step in...
Conflicting results have been reported on the influence of Polymyxin-B hemoperfusion treatment systemic inflammation markers. The aim study was to assess in a randomized control trial plasma cytokine concentrations septic shock due peritonitis. A panel 10 pro- or anti-inflammatory cytokines measured 213 patients with peritonitis-induced enrolled ABDOMIX testing impact 2 sessions standard treatment. Gram-negative bacteria were identified 69% patients. In overall population, baseline not...
Abstract Objectives Ceftaroline could be suitable to treat early-onset ventilator-associated pneumonia (VAP) because of its antibacterial spectrum. However, augmented renal clearance (ARC) is frequent in ICU patients and may affect ceftaroline pharmacokinetics efficacy. The objective the study was explore impact ARC on evaluate whether currently recommended dosing regimen (600 mg every 12 h) appropriate VAP patients. Methods A population pharmacokinetic model developed using data from 18...
Summary Background: Preoxygenation is recommended in pediatric anesthesia but it has been poorly assessed. Fractional expired oxygen concentration (F ET O 2 ) a preoxygenation monitor. The aim of this prospective study children was to compare three techniques by the measurement F 2. Methods: Twenty (6–15 years) were included. measured with child supine position, holding facemask. value after 3 min calm breathing room air (baseline) and during performed random order: tidal volume using an...
In France, liver grafts that have been refused by at least 5 teams are considered for rescue allocation (RA), with the choice of recipient being team's discretion. Although this system permits use otherwise discarded in a context organ shortage, outcomes and potential benefits need to be assessed.Between 2011 2015, RA (n = 33) were compared SA 321) single French center.Liver group older (63 ± 17 years vs 54 18 years, P 0.007) had higher DRI (1.86 0.45 1.61 0.47, 0.010). Recipients lower...
A single-use flexible bronchoscope with a large suction channel has become available recently and we have evaluated this innovative device. Firstly, bronchoalveolar lavage was performed quantified in ventilated piglets. Next, the three intensive care units satisfaction questionnaire carried out. Sixteen lavages were piglets recovery rate of 83 (79–86 [72–89])% instilled volume. Quality performance all devices tested identical. The medical as follows: 'acceptable' to 'very good' for quality...
Shock includes different pathophysiological mechanisms not fully understood and remains a challenge to manage. Exhaled breath condensate (EBC) may contain relevant biomarkers that could help us make an early diagnosis or better understand the metabolic perturbations resulting from this pathological situation.we aimed establish metabolomics signature of EBC patients in shock with acute respiratory failure pilot study.We explored 12 compared 14 controls using LC-HRMS. We used non-targeted...