Charlotte Salmon Gandonnière
A5085471838- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Acute Kidney Injury Research
- Cardiac Arrest and Resuscitation
- COVID-19 and Mental Health
- Chronic Kidney Disease and Diabetes
- COVID-19 and healthcare impacts
- Healthcare Systems and Challenges
- Family and Patient Care in Intensive Care Units
- Nosocomial Infections in ICU
- Neurological Complications and Syndromes
- Mechanical Circulatory Support Devices
- Diversity and Career in Medicine
- Pregnancy and preeclampsia studies
- Pneumonia and Respiratory Infections
- Inhalation and Respiratory Drug Delivery
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Healthcare cost, quality, practices
- Disaster Response and Management
- Clinical Reasoning and Diagnostic Skills
- Protein Tyrosine Phosphatases
Centre Hospitalier Universitaire de Tours
2015-2024
Université de Tours
2016-2023
Université de Bourgogne
2023
Inserm
2019-2023
Université de Strasbourg
2023
Research Network (United States)
2023
French Clinical Research Infrastructure Network
2022-2023
Clinical Investigation Center Plurithematic Tours
2018-2022
Adaptation Biologique et Vieillissement
2020-2022
Thion Medical (France)
2017
BackgroundWhether preventive inhaled antibiotics may reduce the incidence of ventilator-associated pneumonia is unclear.MethodsIn this investigator-initiated, multicenter, double-blind, randomized, controlled, superiority trial, we assigned critically ill adults who had been undergoing invasive mechanical ventilation for at least 72 hours to receive amikacin a dose 20 mg per kilogram ideal body weight once daily or placebo 3 days. The primary outcome was first episode during 28 days...
There is an absence of controlled clinical data showing bronchodilation effectiveness after nebulization via nasal high-flow therapy circuits.Twenty-five patients with reversible airflow obstruction received, in a randomized order: (1) 2.5 mg albuterol delivered jet nebulizer facial mask; (2) vibrating mesh placed downstream humidification chamber (30 L/min and 37 °C); (3) without nebulization. All three conditions induced significant individual increases forced expiratory volume one second...
Abstract Background Delaying time to prone positioning (PP) may be associated with higher mortality in acute respiratory distress syndrome (ARDS) due coronavirus disease 2019 (COVID-19). We evaluated the use and impact of early PP on clinical outcomes intubated patients hospitalized intensive care units (ICUs) for COVID-19. Methods All ARDS COVID-19 were involved a secondary analysis from prospective multicenter cohort study COVID-ICU network including 149 ICUs across France, Belgium...
Abstract High concentrations of extracellular ATP (eATP) resulting from cell damage may be found during an ischemia/reperfusion (I/R) episode at the site injury. eATP activates purinergic receptors in dendritic cells (DCs) and inhibit inflammation. This immunosuppressive activity could interest field I/R, which is inflammatory condition involved myocardial infarction, stroke, solid organ transplantation. However, specific receptor responsible for this effect remains to identified. In study,...
Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring intensive care unit (ICU) have a high incidence of hospital-acquired infections; however, data regarding hospital acquired bloodstream infections (BSI) are scarce. We aimed to investigate risk factors outcome BSI in critically ill infectious disease-19 (COVID-19) patients.We performed an ancillary analysis multicenter prospective international cohort study (COVID-ICU study) that included...
Limitations of life-sustaining therapies (LST) practices are frequent and vary among intensive care units (ICUs). However, scarce data were available during the COVID-19 pandemic when ICUs under intense pressure. We aimed to investigate prevalence, cumulative incidence, timing, modalities, factors associated with LST decisions in critically ill patients. did an ancillary analysis European multicentre COVID-ICU study, which collected from 163 France, Belgium Switzerland. ICU load, a parameter...
Abstract Background Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring mechanical ventilation suffer from a high incidence of ventilator associated pneumonia (VAP), mainly related to Enterobacterales. Data regarding extended-spectrum beta-lactamase producing Enterobacterales (ESBL-E) VAP are scarce. We aimed investigate risk factors outcomes ESBL-E among critically ill infectious disease-19 (COVID-19) patients who developed VAP. methods...
Abstract Background Previous retrospective research has shown that maintaining prone positioning (PP) for an average of 40 h is associated with increase survival rates in intubated patients COVID-19-related acute respiratory distress syndrome (ARDS). This study aims to determine whether a cumulative PP duration more than 32 during the first 2 days intensive care unit (ICU) admission increased compared or less. Methods ancillary analysis from previous large international observational...
Abstract Background Predicting outcomes of critically ill intensive care unit (ICU) patients with coronavirus-19 disease (COVID-19) is a major challenge to avoid futile, and prolonged ICU stays. Methods The objective was develop predictive survival models for COVID-19 after 1-to-2 weeks in ICU. Based on the COVID–ICU cohort, which prospectively collected characteristics, management, COVID-19. Machine learning used dynamic, clinically useful able predict 90-day mortality using data day (D) 1,...
Abstract Background: Acute kidney injury (AKI) is associated with significant morbidity and mortality, particularly in unstable critically ill patients. In this context, serum creatinine concentration an imperfect tool for estimating glomerular filtration rate (GFR), index of renal function. The objective pilot study was to evaluate the feasibility measuring iohexol clearance GFR assessment patients acute circulatory failure at intensive care unit (ICU) admission. Methods: ICU were...
Abstract Background The medical workforce has been feminized for the last two decades worldwide. Nonetheless, women remain under-represented among intensivists. We conducted a survey French intensivists to assess their professional and personal quality of life perception potential gender discrimination at work. Methods an observational descriptive study by sending survey, designed group FEMMIR (FEmmes Médecins en Médecine Intensive Réanimation), in France, using primarily Société de...
To assess glomerular filtration rate in the early phase of acute circulatory failure by measuring iohexol plasma clearance.Interventional prospective multicentric study.Three French ICUs tertiary teaching hospitals.Patients with within 12 hours after ICU admission.IV administration a nontoxic 5-mL dose iohexol. Collection nine arterial blood samples over 24 for concentration measurements. Iohexol clearance calculation population pharmacokinetic model. was an estimation mean hours.Among 99...
Introduction Prognosis of patients with COVID-19 depends on the severity pulmonary affection. The most severe cases may progress to acute respiratory distress syndrome (ARDS), which is associated a risk long-term repercussions function and neuromuscular outcomes. functional forms have major impact quality life, impair ability return work or exercise. Social inequalities in healthcare influence prognosis, socially vulnerable individuals more likely develop disease. We describe here protocol...
Iodinated contrast media may contribute to acute kidney injury. However, several recent works suggest that this toxicity is minimal in the clinical setting. Recently, urinary G1 cell-cycle arrest proteins tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin like growth factor binding protein 7 (IGFBP-7) were identified as highly sensitive specific biomarkers for early detection aggression. The impact administration on those has not been specifically evaluated but could provide clues...
OBJECTIVES: Static glomerular filtration rate formulas are not suitable for critically ill patients because of nonsteady state and variation in the volume distribution. Kinetic remain to be evaluated against a gold standard. We assessed most accurate kinetic formula as compared iohexol clearance among with shock. DESIGN: Retrospective multicentric study. SETTING: Three French ICUs tertiary teaching hospitals. PATIENTS: Fifty-seven within first 12 hours MEASUREMENTS AND MAIN RESULTS: On day...
Physician abstractsOral communicationsO1 Pulmonary embolism related sudden cardiac arrest admitted alive at hospital: characteristics and outcomesWulfran Bougouin1, Eloi Marijon1, Benjamin Planquette2, Nicole Karam1, Florence Dumas3, David Celermajer4, Daniel Jost5, Lionel Lamhaut6, Frankie Beganton7, Alain Cariou8, Guy Meyer9, Xavier Jouven10, Sudden Death Expertise Center 1Cardiologie, Hôpital Européen Georges-Pompidou, Rue Leblanc, Paris, France; 2Usip, Hopital Europeen 3Service d'accueil...