Muriel Fartoukh
A5018007709- Respiratory Support and Mechanisms
- Vascular Anomalies and Treatments
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrest and Resuscitation
- Tracheal and airway disorders
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Hemoglobinopathies and Related Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antibiotic Use and Resistance
- Lung Cancer Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Atrial Fibrillation Management and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Emergency and Acute Care Studies
- COVID-19 and healthcare impacts
- Pleural and Pulmonary Diseases
- Vasculitis and related conditions
Sorbonne Université
2016-2025
Inserm
2009-2025
Hôpital Tenon
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Institut Mondor de Recherche Biomédicale
2017-2025
Université Paris-Est Créteil
2015-2025
Sorbonne Paris Cité
2019-2024
Université Gustave Eiffel
2021-2024
Université Sorbonne Nouvelle
2019-2024
THERANOSCAN : Biomarqueurs Théranostiques des Cancers Bronchiques Non à Petites Cellules
2024
Whether noninvasive ventilation should be administered in patients with acute hypoxemic respiratory failure is debated. Therapy high-flow oxygen through a nasal cannula may offer an alternative hypoxemia.
<h3>Importance</h3> Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19). <h3>Objective</h3> To determine whether tocilizumab (TCZ) improves outcomes patients hospitalized moderate-to-severe COVID-19 pneumonia. <h3>Design, Setting, Particpants</h3> This cohort-embedded, investigator-initiated, multicenter, open-label, bayesian randomized clinical trial investigating moderate or severe requiring at least 3 L/min...
ANY PHYSICIANS BELIEVEthat the pulmonary artery catheter (PAC) is useful for diagnosis and treatment of cardiopulmonary disturbances assessing volume status in critically ill patients. 1,2However, investigators have raised doubts about safety PAC 3,4 because its use may be associated with direct complications 5 or harmful effects related to inappropriate decisions resulting from misinterpretation data. 6he most serious concern was by retrospective study Connors et al, 4 which suggested that...
Corticosteroid therapy induces potentially detrimental hyperglycemia in septic shock. In addition, the benefit of adding fludrocortisone this setting is unclear.To test efficacy intensive insulin patients whose shock was treated with hydrocortisone and to assess, as a secondary objective, fludrocortisone.A multicenter, 2 x factorial, randomized trial, involving 509 adults who presented multiple organ dysfunction, defined by Sequential Organ Failure Assessment score 8 or more, had received...
Patients with COVID-19 pneumonia have an excess of inflammation and increased concentrations cytokines including interleukin-1 (IL-1). We aimed to determine whether anakinra, a recombinant human IL-1 receptor antagonist, could improve outcomes in patients hospital mild-to-moderate pneumonia.In this multicentre, open-label, Bayesian randomised clinical trial (CORIMUNO-ANA-1), nested within the CORIMUNO-19 cohort, we recruited from 16 University hospitals France pneumonia, severe acute...
Abstract Aims Out-of-hospital cardiac arrest (OHCA) without return of spontaneous circulation (ROSC) despite conventional resuscitation is common and has poor outcomes. Adding extracorporeal membrane oxygenation (ECMO) to cardiopulmonary (extracorporeal-CPR) increasingly used in an attempt improve Methods results We analysed a prospective registry 13 191 OHCAs the Paris region from May 2011 January 2018. compared survival at hospital discharge with extracorporeal-CPR identified factors...
In the Île-de-France region (henceforth termed Greater Paris), extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) was considered early in COVID-19 pandemic. We report ECMO network organisation and outcomes during first wave of pandemic.In this multicentre cohort study, we present an analysis all adult patients with laboratory-confirmed SARS-CoV-2 infection ARDS requiring who were admitted to 17 Paris intensive care units between March 8 June 3,...
In patients with acute hypoxemic respiratory failure, noninvasive ventilation and high-flow nasal cannula oxygen are alternative strategies to conventional therapy. Endotracheal intubation is frequently needed in these a risk of delay, early predictors failure may help clinicians decide early. We aimed identify factors associated treated different oxygenation techniques.Post hoc analysis randomized clinical trial.Twenty-three ICUs.Patients rate greater than 25 breaths/min PaO2/FIO2 ratio...
<h3>Importance</h3> The high mortality rate in critically ill elderly patients has led to questioning of the beneficial effect intensive care unit (ICU) admission and a variable ICU use among this population. <h3>Objective</h3> To determine whether recommendation for systematic reduces 6-month compared with usual practice. <h3>Design, Setting, Participants</h3> Multicenter, cluster-randomized clinical trial 3037 aged 75 years or older, free cancer, preserved functional status (Index...
The correct management of immunocompromised patients with pneumonia is debated. We evaluated the prevalence, risk factors, and characteristics coming from community pneumonia.We conducted a secondary analysis an international, multicenter study enrolling adult hospitalized in 222 hospitals 54 countries worldwide. Risk factors for immunocompromise included AIDS, aplastic anemia, asplenia, hematological cancer, chemotherapy, neutropenia, biological drug use, lung transplantation, chronic...
Abstract Background Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced distress (ARDS) causes high mortality. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have potentially relevant immune-modulatory properties, whose place in ARDS treatment is not established. This phase 2b trial was undertaken to assess the efficacy of UC-MSCs patients with SARS–CoV-2-induced ARDS. Methods multicentre, double-blind, randomized, placebo-controlled (STROMA–CoV-2) recruited...
Airway occlusion pressure at 100 ms (P0.1) reflects central respiratory drive.
The clinical pulmonary infection score-original or modified-has been proposed for the diagnosis and management of ventilator-associated pneumonia. In 79 episodes suspected pneumonia, we prospectively assessed diagnostic accuracy physicians' assessment probability modified score, both measured before (pretest) after (post-test) incorporating gram stains results, using bronchoalveolar lavage fluid culture as reference test. pretest estimate was inaccurate (sensitivity 50%, specificity 58%);...
Primary pulmonary hypertension (PPH) is characterized by intimal fibrosis and cell proliferation (including fibroblasts, smooth muscle endothelial cells) in the distal arterial tree. Considerable interest has been generated recent reports of PPH human immunodeficiency virus (HIV)-1-infected individuals. Although lack evidence for a artery infection suggested that such cases HIV may act through mediator release rather than direct infection, mechanisms underlying HIV-associated remain poorly...
In a subset of patients with primary pulmonary hypertension (PPH), high doses oral calcium-channel blockers (CCB) produce sustained clinical and haemodynamic improvement. However, significant side-effects have been reported during acute testing CCB. Therefore, to identify accurately who may benefit from long-term CCB therapy, there is need for safe, potent short-acting vasodilator. The aim this study was compare the response inhaled nitric oxide (NO) in 33 consecutive PPH. A vasodilator...
Diminished exercise capacity in advanced pulmonary histiocytosis X does not appear to be related ventilatory limitation but may vascular dysfunction. Pulmonary hemodynamics and respiratory function were studied 21 consecutive patients with X, compared parameters of other severe chronic lung diseases (29 obstructive disease 14 idiopathic fibrosis). All displayed hypertension: mean arterial pressure, 59 ± 4 mm Hg; cardiac index, 2.6 0.8 L/min/m2; total resistance, 25 3 IU/m2 (p < 0.05, as...