Jean-Baptiste Lascarrou
A5076352162- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Sepsis Diagnosis and Treatment
- Thermal Regulation in Medicine
- Clinical Nutrition and Gastroenterology
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Tracheal and airway disorders
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury Research
- Mechanical Circulatory Support Devices
- Heart Rate Variability and Autonomic Control
- Nutrition and Health in Aging
- Foreign Body Medical Cases
- Anesthesia and Sedative Agents
- Pneumonia and Respiratory Infections
- Palliative Care and End-of-Life Issues
- Venous Thromboembolism Diagnosis and Management
- Non-Invasive Vital Sign Monitoring
- Disaster Response and Management
- Childhood Cancer Survivors' Quality of Life
Centre Hospitalier Universitaire de Nantes
2008-2024
Inserm
2014-2024
Nantes Université
2017-2024
Paris Cardiovascular Research Center
2018-2023
Université Paris Cité
2021-2023
Laboratoire Motricité, Interactions, Performance
2023
Maternité Port Royal
2023
Centre d'Investigation Clinique de Nantes
2017-2022
Baxter (United States)
2022
Hôpital Cochin
2022
Moderate therapeutic hypothermia is currently recommended to improve neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiac arrest. However, the effectiveness of moderate patients nonshockable rhythms (asystole or pulseless electrical activity) debated.
<h3>Importance</h3> Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information available on adverse peri-intubation events. <h3>Objective</h3> To evaluate incidence nature events to assess current practice <h3>Design, Setting, Participants</h3> The International Observational Study Understand Impact Best Practices Airway Management Critically Ill Patients (INTUBE) study was an international, multicenter, prospective...
Previous research suggested that soluble human recombinant thrombomodulin may reduce mortality among patients with sepsis-associated coagulopathy.To determine the effect of vs placebo on 28-day all-cause coagulopathy.The SCARLET trial was a randomized, double-blind, placebo-controlled, multinational, multicenter phase 3 study conducted in intensive care units at 159 sites 26 countries. All adult admitted to one participating between October 2012 and March 2018 coagulopathy concomitant...
Reignier, Jean*†; Mercier, Emmanuelle‡; Le Gouge, Amelie§; Boulain, Thierry║; Desachy, Arnaud¶; Bellec, Frederic#; Clavel, Marc**; Frat, Jean-Pierre††; Plantefeve, Gaetan‡‡; Quenot, Jean-Pierre§§; Lascarrou, Jean-Baptiste* For the Clinical Research in Intensive Care and Sepsis Group Author Information
In the intensive care unit (ICU), orotracheal intubation can be associated with increased risk of complications because patient may acutely unstable, requiring prompt intervention, often by a practitioner nonexpert skills. Video laryngoscopy decrease this improving glottis visualization.To determine whether video increases frequency successful first-pass compared direct in ICU patients.Randomized clinical trial 371 adults while being treated at 7 ICUs France between May 2015 and January...
In patients with acute hypoxemic respiratory failure, noninvasive ventilation and high-flow nasal cannula oxygen are alternative strategies to conventional therapy. Endotracheal intubation is frequently needed in these a risk of delay, early predictors failure may help clinicians decide early. We aimed identify factors associated treated different oxygenation techniques.Post hoc analysis randomized clinical trial.Twenty-three ICUs.Patients rate greater than 25 breaths/min PaO2/FIO2 ratio...
Abstract Background Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence the respiratory management COVID-19-related acute failure (C-ARF) resulted in wide variation clinical practice. Methods Using a Delphi process, an international panel 39 experts developed practice statements C-ARF areas where is absent or limited. Agreement was defined as achieved when > 70% voted for given option Likert scale...
The COVID-19 pandemic is responsible for many hospitalizations in intensive care units (ICU), with widespread use of invasive mechanical ventilation (IMV) which exposes patients to the risk ventilator-associated pneumonia (VAP). characteristics VAP remain unclear.
Rationale: Cardiovascular instability/collapse is a common peri-intubation event in patients who are critically ill. Objectives: To identify potentially modifiable variables associated with cardiovascular (i.e., systolic arterial pressure <65 mm Hg [once] or <90 for >30 minutes; new/increased vasopressor requirement; fluid bolus >15 ml/kg, cardiac arrest). Methods: INTUBE (International Observational Study to Understand the Impact and Best Practices of Airway Management In Critically Ill...
Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure a direct vasopressor requirement. In the present prospective observational multinational Outcome in Sepsis Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between bio-ADM initial intensive care unit (ICU) stay short-term outcome order to eventually design biomarker-guided randomized...
Sepsis is the leading cause of acute kidney injury (AKI) in critically ill patients. The Kidney and Septic Shock (Kid-SSS) study evaluated value proenkephalin A 119-159 (penkid)-a sensitive biomarker glomerular function, drawn within 24 hours upon intensive care unit (ICU) admission analyzed using a chemiluminescence immunoassay-for events sepsis septic shock.The Kid-SSS was substudy Adrenomedullin Outcome Severe (AdrenOSS) (NCT02393781), prospective, observational, multinational including...
Abstract Background Previous studies reporting the causes of death in patients with severe COVID-19 have provided conflicting results. The objective this study was to describe and timing admitted intensive care unit (ICU). Methods We performed a retrospective eight ICUs across seven French hospitals. All consecutive adult (aged ≥ 18 years) ICU PCR-confirmed SARS-CoV-2 infection acute respiratory failure were included analysis. deaths reported based on medical records. Results From March 1,...
The aim of this study is to determine whether severe COVID-19 patients harbour a higher risk ICU-acquired pneumonia.This retrospective multicentre cohort comprised all consecutive admitted seven ICUs for pneumonia during the first surge in France. Inclusion criteria were laboratory-confirmed SARS-CoV-2 infection and requirement invasive mechanical ventilation 48 h or more. Control groups two historical cohorts mechanically ventilated ICU bacterial non-SARS-CoV-2 viral pneumonia. outcome...
Abstract Background Group A Streptococcus is responsible for severe and potentially lethal invasive conditions requiring intensive care unit (ICU) admission, such as streptococcal toxic shock-like syndrome (STSS). rebound of group (iGAS) infection after COVID-19-associated barrier measures has been observed in children. Several intensivists French adult ICUs have reported similar bedside impressions without objective data. We aimed to compare the incidence iGAS before COVID-19 pandemic,...
Severe Pneumocystis jirovecii pneumonia (PJP) requiring intensive care has been the subject of few prospective studies. It is unclear whether delayed curative antibiotic therapy may impact survival in these severe forms PJP. The corticosteroid combined with antibiotics also unclear.
Abstract Background Chimeric antigen receptor T-cell (CAR-T) therapy is increasingly used in patients with refractory haematological malignancies but can induce severe adverse events. We aimed to describe the clinical features and outcomes of admitted intensive care unit (ICU) after CAR-T therapy. Methods This retrospective observational cohort study included consecutive adults either two French ICUs 2018–2022 within 3 months Results Among 238 given therapy, 84 (35.3%) required ICU admission...
Thyroid storm represents a rare but life-threatening endocrine emergency. Only data are available on its management and the outcome of most severe forms requiring ICU admission. We aimed to describe clinical manifestations, in-ICU 6-month survival rates patients with those thyroid admission.Retrospective, multicenter, national study over an 18-year period (2000-2017).Thirty-one French ICUs.The local medical records from each participating were screened using International Classification...
Intubation is frequently required for patients in the intensive care unit (ICU) but associated with high morbidity and mortality mainly emergency procedures presence of severe organ failures. Improving intubation procedure a major goal all ICU physicians worldwide, videolaryngoscopy may play relevant role.Videolaryngoscopes are heterogeneous entity, including Macintosh blade-shaped optical laryngoscopes, anatomically shaped blade without tube guide guide, which might have theoretical...