A5064668228- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Ultrasound in Clinical Applications
- Respiratory Support and Mechanisms
- Thermal Regulation in Medicine
- Organ and Tissue Transplantation Research
- Organ Donation and Transplantation
- Intensive Care Unit Cognitive Disorders
- Organ Transplantation Techniques and Outcomes
- Esophageal and GI Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Liver Disease Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Liver Disease and Transplantation
- Restraint-Related Deaths
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Abdominal Trauma and Injuries
- Heart Rate Variability and Autonomic Control
- Appendicitis Diagnosis and Management
- Bacterial Infections and Vaccines
- Epilepsy research and treatment
- Traumatic Brain Injury Research
Centre Hospitalier Universitaire de Limoges
2004-2023
Maternité Port Royal
2023
Université de Limoges
2002-2022
Institut Cochin
2022
Inserm
2010-2021
Assistance Publique – Hôpitaux de Paris
2015-2021
Hôpital Universitaire Dupuytren
2004-2021
Hôpital Lariboisière
2019-2021
Hôpital Dupuytren
2010-2020
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2020
Moderate therapeutic hypothermia is currently recommended to improve neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiac arrest. However, the effectiveness of moderate patients nonshockable rhythms (asystole or pulseless electrical activity) debated.
To assess the ability of ultrasonography to identify presence and volume pleural effusion in intensive care unit setting.Prospective descriptive clinical study.Medical-surgical a teaching hospital.Initial study group (group I) consisted 97 patients (mean [+/-SD] Simplified Acute Physiology Score II, 40 +/- 14) with clinically suspected effusion. Fifty-one were mechanically ventilated 55 underwent unilateral or bilateral thoracentesis (58 procedures). All supine chest radiography at bedside....
Despite advances in care, mortality and morbidity remain high adults with acute bacterial meningitis, particularly when due to Streptococcus pneumoniae. Induced hypothermia is beneficial other conditions global cerebral hypoxia.To test the hypothesis that induced improves outcome patients severe meningitis.An open-label, multicenter, randomized clinical trial 49 intensive care units France, February 2009-November 2011. In total, 130 were assessed for eligibility 98 comatose (Glasgow Coma...
Targeted temperature management is recommended after out-of-hospital cardiac arrest. Whether advanced internal cooling superior to basic external remains unknown. The aim of this multicenter, controlled trial was evaluate the benefit endovascular versus surface cooling.Inclusion criteria were following: age 18 79 years, arrest related a presumed cause, time return spontaneous circulation <60 minutes, delay between and inclusion <240 unconscious patient before start cooling. Exclusion...
Since 2003, we have routinely used percutaneous coronary intervention (PCI) and mild therapeutic hypothermia (MTH) to treat patients < 80 years of age after out-of-hospital cardiac arrest (OHCA) related ventricular fibrillation. The aim our study was evaluate the prognostic impact routine PCI in association with MTH potential influence age.We studied 111 consecutive resuscitated successfully following OHCA shock-sensitive rhythm. They were divided into five groups according age: 45 (n = 22,...
Severe Pneumocystis jirovecii pneumonia (PJP) requiring intensive care has been the subject of few prospective studies. It is unclear whether delayed curative antibiotic therapy may impact survival in these severe forms PJP. The corticosteroid combined with antibiotics also unclear.
Non-invasive evaluation of left ventricular filling pressure has been scarcely studied in critically ill patients. Accordingly, we prospectively assessed the ability transoesophageal echocardiography (TEE) Doppler to predict an invasive pulmonary artery occlusion (PAOP) < or = 18 mmHg ventilated patients.During two consecutive 3-year periods, TEE parameters were compared right heart catheterisation derived PAOP used as reference 88 patients, haemodynamically stable and sinus rhythm (age: 63...
Abstract Introduction We evaluated the efficacy of and tolerance to mild therapeutic hypothermia achieved using an endovascular cooling system, its ability reach maintain a target temperature 33°C after cardiac arrest. Methods This study was conducted in medical-surgical intensive care unit urban university hospital. Forty patients admitted following out-of-hospital arrest underwent induced (MIH). Core monitored continuously for five days Foley catheter equipped with sensor. Any equipment...
Abstract Background Different modes of death are described in selected populations, but few data report the characteristics a general intensive care unit population. This study analyzed causes and critically ill patients compared anticipated to unexpected counterparts. Methods An observational multicenter cohort was performed 96 units. During 1 yr, each randomized participate during 1-month period. Demographic data, organ failures (Sequential Organ Failure Assessment subscore greater than or...
Circulatory failure during brain death organ donor resuscitation is a problem that compromises recovery of organs. Combined administration steroid, thyroxine and vasopressin has been proposed to optimize the management deceased donors before However single hydrocortisone not rigorously evaluated in any trial.In this prospective multicenter cluster study, 259 subjects were included. Administration low-dose steroids composed steroid group (n = 102).Although there more patients who received...
To describe the characteristics, management, and outcome of patients admitted to ICUs for pheochromocytoma crisis.A 16-year multicenter retrospective study.Fifteen university nonuniversity in France.Patients ICU crisis.None.We included 34 with a median age 46 years (40-54 yr); 65% were males. At admission, Sequential Organ Failure Assessment score was 8 (4-12) Simplified Acute Physiology Score II 49.5 (27-70). The left ventricular ejection fraction consistently decreased value 30% (15-40%)....
Family members of brain dead patients experience an unprecedented situation in which not only they are told that their loved one is but also asked to consider organ donation. The objective this qualitative study was determine 1) what it means for family make the decision and take responsibility, 2) how interact with deceased patient ICU, 3) describe impact process on bereavement process.Qualitative using interviews bereaved who were approached donation after death relative ICU (brain...
Studies show that the quality of end-of-life communication and care have a significant impact on living long after death relative been implicated in burden psychological symptoms ICU experience. In case organ donation, patient's relatives are centrally involved decision-making process; yet, few studies examined death.To assess experience donation process grief brain-dead patients who discussed ICU.We conducted multicenter longitudinal study 28 ICUs France. Participants were approached to...
Meta-analyses of nonrandomized studies have provided conflicting data on therapeutic hypothermia, or targeted temperature management (TTM), at 33°C in patients successfully resuscitated after nonshockable cardiac arrest. Nevertheless, the latest recommendations issued by International Liaison Committee Resuscitation and European Council recommend hypothermia. New are available adverse effects notably infectious complications. The risk/benefit ratio hypothermia arrest is unclear. HYPERION a...
Left ventricular (LV) diastolic dysfunction is highly prevalent in the general population and associated with a significant morbidity mortality. Its prognostic role patients sustaining septic shock intensive care unit (ICU) remains controversial. Accordingly, we investigated whether LV function was independently ICU mortality cohort of assessed using critical echocardiography.Over 5-year period, hospitalized Medical-Surgical who underwent an echocardiographic assessment digitally stored...