A5056627667- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Plant Virus Research Studies
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- Parvovirus B19 Infection Studies
- Herpesvirus Infections and Treatments
- Virology and Viral Diseases
- Animal Disease Management and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
Marion Technologies (France)
2018-2024
bioMérieux (France)
2016-2024
Delta Air Lines (United States)
2024
Inserm
2016-2022
Université de Limoges
2018-2022
Torque Teno virus (TTV) is non-pathogenic, highly prevalent and reflects the immune status of its host. TTV plasma load was suggested for risk stratification graft rejection infection post kidney-transplantation, which most studies applied an in-house PCR. Recently, a commercial PCR CE-certified clinical use. The present study designed to assess performance as quantified by in prediction infection. Patients events were selected from prospective TTV-POET trial, including 683 consecutive adult...
Abstract Optimization of individual immunosuppression, which reduces the risks both graft loss and patients' death, is considered best approach to improve long‐term outcomes renal transplantation. Torque Teno Virus (TTV) DNAemia has emerged as a potential biomarker reflecting depth therapeutic immunosuppression during initial year post‐transplantation. However, its efficacy in monitoring remains uncertain. In cohort study involving 34 stable kidney transplant recipients 124 healthy...
Abstract The viral load of the ubiquitous and nonpathogenic torque teno virus (TTV) is associated with grade immunosuppression its host. development next‐generation sequencing (NGS) allowed to describe human virome blood compartment in transplanted patients, showed that TTV most important part virome. This study a descriptive retrospective pilot plasma samples from 15 matched donors recipients. After sample processing, nucleic acids were amplified by rolling circle amplification submitted...
Torque Teno virus (TTV) load is linked with the functionality of its host's immune system and has been proposed as a potential monitoring tool for immune-modulating therapy. However, immunological mechanisms TTV control are incompletely understood. To assess effect classical complement pathway on TTV, 64 healthy volunteers 10 kidney transplant recipients treated anti-C1s antibody sutimlimab were analyzed serum copy numbers (c/mL) by qPCR. Overall, correlation was observed between decrease in...
Obesity affects a rising proportion of the population and is an important risk factor for unfavorable outcomes in viral disease including severe acute respiratory syndrome coronavirus 2- associated diseases. Torque Teno virus (TTV) ubiquitous apathogenic which reflects immune function its host. The aim this study was to investigate association between obesity TTV load - indirect marker compromised response. quantified by R-GENE® PCR total 89 participants 30 were lean (BMI <25 kg/m2) 59 obese...
Torque Teno virus (TTV) load is linked with the functionality of its host's immune system and has been proposed as a potential monitoring tool for immune-modulating therapy. However, immunological mechanisms TTV control are incompletely understood. To assess effect classical complement pathway on TTV, 64 healthy volunteers 10 kidney transplant recipients treated anti-C1s antibody sutimlimab were analyzed serum copy numbers (c/mL) by qPCR. Overall, correlation was observed between decrease in...
Abstract BACKGROUND AND AIMS The nonpathogenic and ubiquitous Torque Teno virus (TTV) plasma load is associated with immunosuppression in solid organ transplant recipients. An optimal TTV range has been defined for risk stratification of graft rejection infection the first year post kidney applying an in-house PCR. Recently, a commercial PCR—the R-GENE® kit—has CE certified clinical use. present study was designed to validate refine kit. METHOD Patients events were selected from prospective...