A5019943317- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Renal Transplantation Outcomes and Treatments
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Otitis Media and Relapsing Polychondritis
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Sclerosis and Related Diseases
- Complement system in diseases
- Inflammatory Myopathies and Dermatomyositis
- Ocular Diseases and Behçet’s Syndrome
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders
- Vascular Anomalies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Transplantation: Methods and Outcomes
- T-cell and B-cell Immunology
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Hospices Civils de Lyon
2015-2025
Hôpital Edouard Herriot
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Hôpital de la Croix-Rousse
2013-2024
Centre International de Recherche en Infectiologie
2020-2022
Centre National de la Recherche Scientifique
2020-2022
Inserm
2018-2022
École Normale Supérieure de Lyon
2020-2022
Fédération française de cardiologie
2021
Communauté urbaine de Lyon
2019
Current doctrine is that microvascular inflammation (MVI) triggered by a transplant -recipient antibody response against alloantigens (antibody-mediated rejection) the main cause of graft failure. Here, we show histological lesions are not mediated antibodies in approximately half participants cohort 129 renal recipients with MVI on biopsy. Genetic analysis these patients shows higher prevalence mismatches between donor HLA I and recipient inhibitory killer cell immunoglobulin-like receptors...
VEXAS syndrome in a woman Get access Thomas Barba, Barba Internal Medicine, University Hospital Edouard Herriot, Hospices Civils de LyonInternational Center for Infectiology Research (CIRI), Inserm U1111, of Lyon, CNRSLyon Immunology Federation (LIFE) Correspondence to: Service Médecine Interne, Hôpital 5 Place d’Arsonval, F-69003 France. E-mail: thomas.barba@chu-lyon.fr Search other works by this author on: Oxford Academic PubMed Google Scholar Yvan Jamilloux, Jamilloux International...
Background Binding of donor-specific antibodies (DSAs) to kidney allograft endothelial cells that does not activate the classic complement cascade can trigger recruitment innate immune effectors, including NK cells. Activated contribute microvascular inflammation leading chronic antibody-mediated rejection (AMR). Recipient also antibody-independent by sensing absence self HLA class I molecules (“missing self”) on This translational study investigated whether condition missing amplifies...
Antibody-mediated rejection is currently the leading cause of transplant failure. Prevailing dogma predicts that B cells differentiate into anti-donor-specific antibody (DSA)-producing plasma only with help CD4+ T cells. Yet, previous studies have shown dependence on helper decreases when high amounts protein antigen are recruited to spleen, two conditions potentially met by organ transplantation. This could explain why a significant proportion recipients develop DSA despite therapeutic...
Hemophagocytic lymphohistiocytosis (HLH) is a critical condition that may lead to organ failure and early death. The aim of this retrospective observational study was describe cohort HLH patients admitted intensive care unit (ICU) investigate the risk factors A positive diagnosis defined by an HScore ≥169. Univariate multivariate analyses were carried out hospital 28-day mortality factors. Between January 2002 July 2014, 71 cases seen at our institution. overall (start ICU admission) 38%...
Kidney transplant recipients (KTRs) have reduced ability to mount adequate antibody response after two doses of the COVID-19 mRNA vaccine. French health authorities allowed a third booster dose (D3) for KTRs, but their is heterogeneous and tools able discriminate responders are lacking.Anti-RBD IgG titers (chemiluminescence immunoassay), spike-specific cellular responses (IFN-γ-releasing assay, IGRA), in vitro serum neutralization virus (the best available correlate protection), were...
Despite the critical role of cytokines in allograft rejection, relation peripheral blood cytokine profiles to clinical kidney transplant rejection has not been fully elucidated. We assessed 28 through multiplex assay 293 samples from recipients at time graft dysfunction. Unsupervised hierarchical clustering identified a subset patients with increased pro-inflammatory levels. This patient was hallmarked by high prevalence (75%) donor-specific anti-human leukocyte antigen antibodies (HLA-DSA)...
The generation of antibodies against donor-specific major histocompatibility complex (MHC) antigens, a type (DSAs), after transplantation requires that recipient's allospecific B cells receive help from T cells. current dogma holds this is exclusively provided by the CD4+ recognize complexes MHC II molecules and peptides derived alloantigens, process called indirect allorecognition. Here, we demonstrated that, allogeneic heart transplantation, CD3ε knockout recipient mice lacking generate...
Magnetic resonance images (MRI) of the brain exhibit high dimensionality that pose significant challenges for computational analysis. While models proposed MRIs analyses yield encouraging results, complexity neuroimaging data hinders generalizability and clinical application. We introduce DUNE, a neuroimaging-oriented encoder designed to extract deep-features from multisequence MRIs, thereby enabling their processing by basic machine learning algorithms. A UNet-based autoencoder was trained...
Abstract Objectives Only a third of patients with eosinophilic granulomatosis polyangiitis (EGPA) are ANCA-positive, mainly directed against MPO. ANCA PR3 rarely found in EGPA. We aimed to examine the significance PR3-ANCA Methods set up retrospective European multicentre cohort including 845 patients. Baseline characteristics and outcomes were analysed compared according status. Results status was available for 734 patients: 508 (69.2%) ANCA-negative, 210 (28.6%) MPO-ANCA 16 (2.2%)...
Abstract Optimization of individual immunosuppression, which reduces the risks both graft loss and patients' death, is considered best approach to improve long‐term outcomes renal transplantation. Torque Teno Virus (TTV) DNAemia has emerged as a potential biomarker reflecting depth therapeutic immunosuppression during initial year post‐transplantation. However, its efficacy in monitoring remains uncertain. In cohort study involving 34 stable kidney transplant recipients 124 healthy...
Abstract Background Patients on maintenance hemodialysis (MHD) are at high risk of infection with SARS-Cov-2 and death due to COVID-19. This vulnerable population has been prioritized for vaccination, but the level protection achieved in these immunocompromised patients is unclear. Objectives To evaluate MHD against COVID-19 after 2 doses (2D) BNT162b2, safety impact immune responses a 3 rd dose (3D). Design Prospective observational. Setting, Patients, intervention measurements REIN...
To report on a large series of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and bronchiectasis, specific focus the timeline occurrence both features.Retrospective nationwide multicenter study diagnosed AAV bronchiectasis.Sixty-one were included, among whom 27 (44.25%) had microscopic polyangiitis (MPA), granulomatosis (GPA), 7 (11.5%) eosinophilic GPA. Thirty-nine (64%) myeloperoxidase (MPO)-ANCA 13 (21%) proteinase 3-ANCA. The diagnosis bronchiectasis...