A5023538431- Spine and Intervertebral Disc Pathology
- Renal Transplantation Outcomes and Treatments
- Spinal Fractures and Fixation Techniques
- Renal Diseases and Glomerulopathies
- Medical and Biological Sciences
- Medical Imaging and Analysis
- COVID-19 Clinical Research Studies
- Cervical Cancer and HPV Research
- Shoulder and Clavicle Injuries
- Pelvic and Acetabular Injuries
- Shoulder Injury and Treatment
- SARS-CoV-2 and COVID-19 Research
- Hip and Femur Fractures
- T-cell and B-cell Immunology
- Organ Donation and Transplantation
- Bone fractures and treatments
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Nerve Injury and Rehabilitation
- Infectious Diseases and Tuberculosis
- Organ and Tissue Transplantation Research
- Transplantation: Methods and Outcomes
- Long-Term Effects of COVID-19
- Orthopaedic implants and arthroplasty
- Organ Transplantation Techniques and Outcomes
Laboratoire de PhysioMédecine Moléculaire
2021-2025
Centre National de la Recherche Scientifique
2015-2025
Centre Hospitalier Universitaire de Nice
2021-2025
Université Côte d'Azur
2018-2025
Hôpital Pasteur
2020-2024
Hospices Civils de Lyon
2014-2022
Hôpital Edouard Herriot
2014-2022
Université Claude Bernard Lyon 1
2014-2022
Observatoire de la Côte d’Azur
2020-2022
Inserm
2014-2021
Antibody-mediated rejection (AMR) is a major cause of kidney graft loss, yet assessment individual risk at diagnosis impeded by the lack reliable prognosis assay. Here, we tested whether capacity anti-HLA antibodies to bind complement components allows accurate stratification time AMR diagnosis. Among 938 transplant recipients for whom biopsy was performed between 2004 and 2012 Lyon University Hospitals, 69 fulfilled criteria were enrolled. Sera banked screened presence donor-specific (DSAs)...
Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim this registry-based observational study was to explore characteristics outcomes transplants included French nationwide Registry Solid Organ Transplant Recipients with Covid-19. Covid-19 diagnosed symptomatic patients who had positive PCR assay for SARS-CoV-2 or having typical lung lesions imaging. Clinical...
There are no studies which have compared the risk of severe COVID-19 and related mortality between transplant recipients nontransplant patients. We enrolled two groups patients hospitalized for COVID-19, that is, kidney (KTR) from French Registry Solid Organ Transplant (n = 306) a single-center cohort 795). An analysis was performed among subgroups matched age factors or mortality. Severe defined as admission (or transfer) to an intensive care unit, need mechanical ventilation, death. were...
Current doctrine is that microvascular inflammation (MVI) triggered by a transplant -recipient antibody response against alloantigens (antibody-mediated rejection) the main cause of graft failure. Here, we show histological lesions are not mediated antibodies in approximately half participants cohort 129 renal recipients with MVI on biopsy. Genetic analysis these patients shows higher prevalence mismatches between donor HLA I and recipient inhibitory killer cell immunoglobulin-like receptors...
Cell therapy with autologous donor-specific regulatory T cells (Tregs) is a promising strategy to minimize immunosuppression in transplant recipients. Chimeric antigen receptor (CAR) technology has recently been used successfully generate Tregs and overcome the limitations of enrichment protocols based on repetitive stimulations alloantigens. However, ability CAR-Treg control alloreactivity immunocompetent recipients unknown. We first analyzed effect CAR naive, mice receiving skin...
The immunogenicity of a two-dose mRNA COVID-19 vaccine regimen is low in kidney transplant (KT) recipients. Here, we provide thorough assessment the three-dose this population.We performed prospective longitudinal study sixty-one KT recipients given three doses BNT162b2 vaccine. We semi-structured pharmacovigilance interviews and monitored donor-specific antibodies function. compared levels anti-spike IgG, pseudo-neutralization activity against homologous heterologous variants, frequency...
Abstract Dogma holds that plasma cells, as opposed to B cannot bind antigen because they have switched from expression of membrane-bound immunoglobulins (Ig) constitute the B-cell receptor (BCR) production secreted form immunoglobulins. Here we compare phenotypical and functional attributes cells generated by T-cell-dependent T-cell-independent forms hapten NP. We show nature Ig isotype, rather than chemical structure immunizing antigen, defines two functionally distinct populations cells....
Background Binding of donor-specific antibodies (DSAs) to kidney allograft endothelial cells that does not activate the classic complement cascade can trigger recruitment innate immune effectors, including NK cells. Activated contribute microvascular inflammation leading chronic antibody-mediated rejection (AMR). Recipient also antibody-independent by sensing absence self HLA class I molecules (“missing self”) on This translational study investigated whether condition missing amplifies...
Background Transplant recipients face increased cancer mortality due to immunosuppressive treatments. Immune checkpoint inhibitors (ICI) have improved survival rates, but data on the use of these agents in transplant is scarce. ICI may trigger allograft rejection, absolute risk AR between different classes remains be defined. Methods VigiBase ® (WHO’s pharmacovigilance database) was queried for reports involving CTLA4, PD1, or PDL1 inhibitors. Disproportionality analysis compares proportion...
The detection of preformed donor-specific alloantibodies (DSA) with multiplex-bead arrays has led to the common observation that individuals without a history pregnancy, transfusion or transplantation can have circulating anti-HLA antibodies unknown etiology. We retrospectively analyzed risk antibody-mediated rejection (AMR) and graft outcome in 41 kidney transplant recipients DSA etiology (DSA cause-unk) at time transplantation. Twenty-one patients received posttransplantation...
Immune checkpoint inhibitors (ICIs) foster anti-cancer immune responses. Their efficacy comes at the cost of immune-related adverse events (IRAEs). The latter affects various organs, including kidneys, mostly as acute tubulointerstitial nephritis, pathophysiology which remains unclear. We conducted a multicentre case-control study to compare characteristics patients with renal IRAEs (ICI-AKI) those diagnosed other IRAEs.We queried French pharmacovigilance database for all involving ICIs....
Antibody-mediated allograft rejection is an increasingly recognized problem in clinical transplantation. However, the primary location of donor-specific alloantibody (DSA)-producing cells after transplantation have not been identified. The purpose this study was to test contribution allospecific antibody-secreting (ASCs) from different anatomical compartments a mouse model. Fully MHC-mismatched heart allografts were transplanted into three groups recipients: nonsensitized wild type,...
Renal involvement in light chain (LC) deposition disease (LCDD) is typically characterized by nodular glomerulosclerosis and nephrotic range proteinuria. Rare cases of LCDD without glomerular symptoms have been reported, but clinical pathological characteristics this entity remain poorly described. This multi-centre retrospective study included 14 patients with biopsy-proven renal proteinuria <0.5 g/day at diagnosis. Baseline median serum creatinine was 281 (136–594) μmol/L, a filtration...
(1929). LVIII.—Description d'especes nouvelles de Coccinellidae. Annals and Magazine of Natural History: Vol. 4, No. 23, pp. 515-524.
(1931). XXX.—Descriptions d'especes nouvelles appartenant a la famille des Coccinellides (Col.) Annals and Magazine of Natural History: Vol. 8, No. 45, pp. 228-234.
Chimeric antigen receptor T (CAR-T) cells have proven to be a game changer for treating several hematologic malignancies. Randomized controlled trials highlighted potential life-threatening adverse drug reactions (ADRs), including cytokine release syndrome (CRS). Acute renal failure (ARF) has also been reported in 20% of the patients treated. However, an analysis safety supported by large-scale real-life data seems warranted. We queried VigiBase® all reports Standardised MedDRA Query "acute...
Solid organ transplant recipients are at high risk for fatal forms of coronavirus disease 2019 (COVID-19). We conducted a cohort study among kidney (KT) from the French Organ Transplant COVID-19 Registry to investigate association between maintenance immunosuppressive drugs and 60-d mortality.Data all KT with included in February 28, 2020, December 30, were retrieved. evaluated associations death within 60 d using logistic regression, baseline characteristics considered influence outcome or...