Nicolas Bouvier
A5000516885- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Neurological Complications and Syndromes
- Polyomavirus and related diseases
- Pregnancy and Medication Impact
- COVID-19 Clinical Research Studies
- Organ Donation and Transplantation
- French Urban and Social Studies
- Dialysis and Renal Disease Management
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Long-Term Effects of COVID-19
- Transplantation: Methods and Outcomes
- Fungal Infections and Studies
- Actinomycetales infections and treatment
- Pancreatic function and diabetes
- Parvovirus B19 Infection Studies
- Pharmacological Effects and Toxicity Studies
- Historical Studies and Socio-cultural Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Diverse Cultural and Historical Studies
- Biomedical Research and Pathophysiology
Université de Caen Normandie
2016-2025
Centre Hospitalier Universitaire de Caen
2015-2024
Hôpital Edouard Herriot
2022
Memorial University of Newfoundland
2018
Sciences pour L’Œnologie
2016
Institut d'Etudes Politiques de Paris
2016
Normandie Université
2016
Hôpital Georges-Clemenceau
2008-2015
Inserm
2008-2013
Sorbonne Paris Cité
2012
Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim this registry-based observational study was to explore characteristics outcomes transplants included French nationwide Registry Solid Organ Transplant Recipients with Covid-19. Covid-19 diagnosed symptomatic patients who had positive PCR assay for SARS-CoV-2 or having typical lung lesions imaging. Clinical...
Background. Nocardiosis is a rare, life-threatening opportunistic infection, affecting 0.04% to 3.5% of patients after solid organ transplant (SOT). The aim this study was identify risk factors for Nocardia infection SOT and describe the presentation nocardiosis in these patients.
It remains unclear whether physicians should accept transplantation offers for candidates with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test due to the potential risk of severe infection after initiating immunosuppressive therapy. A multicenter observational study was conducted in 19 French solid organ units. Patients on waiting list liver or kidney transplants who had nasopharyngeal swab at time were recorded. Sixty-five patients included. The recipients...
A major side effect of the powerful immunosuppressive drug cyclosporine (CsA) is development a chronic nephrotoxicity whose mechanisms are not fully understood. Recent data suggest that tubular cells play central role in pathogenesis nephropathies. We have shown CsA responsible for endoplasmic reticulum (ER) stress cells. Autophagy has recently been described to be induced by ER and alleviate its deleterious effects. In this study, we demonstrate induces autophagy primary cultured human...
Summary In our study of 117 organ transplant recipients with nocardiosis, a history tumor, invasive fungal infection, donor age, and no acute rejection were independently associated 1-year mortality. Short-course antibiotic treatment (≤120 days), used in 17 patients, appeared promising.
The aim of this study (ClinicalTrials.gov, NCT01744470) was to determine the efficacy and safety two different doses extended-release tacrolimus (TacER) in kidney transplant recipients (KTRs) between 4 12 mo after transplantation. Stable steroid-free KTRs were randomized (1:1) mo: Group A had a 50% reduction TacER dose with targeted trough level (C0) >3 μg/L; group B no change (TacER C0 7–12 μg/L). primary outcome estimated GFR at 1 year. Of 300 patients, intent-to-treat analysis included...
Vitamin D sufficiency is associated with a reduced risk of fractures, diabetes mellitus, cardiovascular events, and cancers, which are frequent complications after renal transplantation. The VITALE (VITamin supplementation in renAL transplant recipients) study multicenter double-blind randomized trial, including nondiabetic adult recipients serum 25-hydroxy vitamin (25(OH) D) levels <30 ng/mL, 12 to 48 months transplantation receive high (100 000 IU) or low doses (12 cholecalciferol every 2...
Abstract Background Belatacept (bela) rescue therapy seems to be a valuable option for calcineurin inhibitor chronic toxicity in kidney transplantation. Nevertheless, the risk of infection associated with bela is not well reported. Methods We report rate opportunistic infections (OPI) after switch multicentric cohort 280 transplant patients. Results Forty-two OPI occurred 34 patients (12.1%), on average 10.8 ± 11.3 months switch. With cumulative exposure 5128 treatment, we found an incidence...
Endoplasmic reticulum (ER) stress is involved in the pathophysiology of kidney disease and aging, but molecular bases underlying biologic outcomes on evolution renal remain mostly unknown. Angiogenin (ANG) a ribonuclease that promotes cellular adaptation under its contribution to ER signaling remains elusive. In this study, we investigated ANG-mediated injury. ANG expression was significantly higher samples from injured human kidneys than normal kidneys, mouse rat specifically induced...
Asymptomatic bacteriuria is frequent in kidney transplant recipients (KTRs). However, there no consensus on diagnosis or management. We conducted a European survey to explore current practice related the and management of asymptomatic adult KTRs.A panel experts from Renal Association-European Dialysis Transplant Association/Developing Education Science Care for Transplantation States working group Study Group Infections Compromised Hosts Society Clinical Microbiology Infectious Diseases...
Calcineurin inhibitors cyclosporine and tacrolimus are effective immunosuppressants, but both substances have the same intrinsic nephrotoxic potential that adversely affects allograft survival in renal transplant patients causes end-stage disease other solid organ or bone marrow recipients. Endothelial cells first biological interface between drugs kidney, calcineurin may influence endothelial function viability a number of ways. Notably, recently been shown to contribute accumulation...
Background. Peritoneal dialysis (PD) is underused in France compared with other countries. In addition, there are tremendous regional discrepancies concerning the utilization rate of PD. This study was carried out to evaluate opinion French nephrologists regarding optimal PD and determine which factors limit development France. Methods. Of 22 regions, 2 regions a high (prevalence >15%) 3 low <10%) were selected. June 2007, from five surveyed by questionnaire. Responses between...
The renal epithelium contributes to the development of inflammation during ischemic injury. Ischemia induces endoplasmic reticulum (ER) stress and activates unfolded protein response (UPR). Ischemic tissues generate distress signals that fibrogenesis may promote adaptive immunity. Interestingly, UPR activate pathways. Our aim was test whether is activated metabolic mediates a tubular inflammatory response. Glucose deprivation, not hypoxia amino acids in human cortical cells culture. This...
Anti-tumor necrosis factor-α (TNFα) therapy has improved the prognosis of many chronic inflammatory diseases. It appears to be well-tolerated by liver-transplant patients. However, their use and safety in kidney-transplant patients have yet determined. In this retrospective study, we identified 16 adult aged 46.5 years (34–51.8) who received anti-TNFα from 7 kidney transplantation centers. The indications for treatment included: bowel disease (n = 8), arthritis 5), AA amyloidosis 1),...
The ribonuclease angiogenin is a component of the mammalian stress response, and functions in both cell-autonomous non-cell-autonomous ways to promote tissue adaptation injury. We recently showed that regulates homeostasis during AKI associated with endoplasmic reticulum (ER) through production transfer RNA fragments interfere translation initiation thereby alleviate ER stress. However, whether paracrine signaling mediated by secretion genuine response kidney injury unknown. Here, we...
De novo donor-specific antibodies (DSAs) are associated with antibody-mediated rejection (AMR) and allograft loss. Whether monitoring of de DSA (dnDSA) paired systematic kidney biopsy should become routine remains to be established.A retrospective multicentric study (9 French transplant units the Spiesser group) included patients without graft dysfunction biopsied because presence dnDSA (One Lambda, mean fluorescence intensity [MFI], >1000).One hundred twenty-three (85 male/38 female; age,...
Conversion from calcineurin-inhibitors (CNIs) to belatacept can help kidney-transplant (KT) recipients avoid CNI-related nephrotoxicity. The risk of associated opportunistic infections (OPIs) is ill-defined. We conducted a multicentric cohort study across 15 French KT-centers in real-life setting. Between 07-2010 and 07-2019, 453 KT were converted CNI- belatacept-based therapy at 19 [0.13-431] months post-transplantation. Most patients, i.e., 332 (79.3%), after 6-months Follow-up time...