A5009032063- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- HIV/AIDS drug development and treatment
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- HIV-related health complications and treatments
- Polyomavirus and related diseases
- Dialysis and Renal Disease Management
- Cytomegalovirus and herpesvirus research
- Neurological Complications and Syndromes
- Chronic Kidney Disease and Diabetes
- Biomedical Ethics and Regulation
- Pregnancy and Medication Impact
- Pneumocystis jirovecii pneumonia detection and treatment
- Acute Kidney Injury Research
- Pharmacological Effects and Toxicity Studies
- Immune Cell Function and Interaction
- Muscle and Compartmental Disorders
- Liver Disease and Transplantation
- Psoriasis: Treatment and Pathogenesis
- CAR-T cell therapy research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Metabolism and Genetic Disorders
- HIV/AIDS Research and Interventions
Guy's and St Thomas' NHS Foundation Trust
2015-2025
Guy's Hospital
2012-2023
Bridgewater Community Healthcare NHS Foundation Trust
2016-2022
British Transplantation Society
2016
HealthPartners
2013
Cell Therapy Catapult
2013
King's College London
2006-2013
National Health Service
2013
Medical Research Council
2011-2013
National Institute for Health Research
2011-2013
Identifying transplant recipients in whom immunological tolerance is established or developing would allow an individually tailored approach to their posttransplantation management. In this study, we aimed develop reliable and reproducible vitro assays capable of detecting renal recipients. Several biomarkers bioassays were screened on a training set that included 11 operationally tolerant recipients, recipient groups following different immunosuppressive regimes, undergoing chronic...
The concept of regulatory T cell (Treg)-based immunotherapy has enormous potential for facilitating tolerance in autoimmunity and transplantation. Clinical translation Treg therapy requires production processes that satisfy the rigors Good Manufacturing Practice (GMP) standards. In this regard, we report our findings on implementation a robust GMP compliant process ex vivo expansion clinical grade Tregs, demonstrating feasibility developed manufacture final product application. This...
Short-term outcomes in kidney transplantation are marred by progressive transplant failure and mortality secondary to immunosuppression toxicity. Immune modulation with autologous polyclonal regulatory T cell (Treg) therapy may facilitate reduction promoting better long-term clinical outcomes. In a Phase I trial, 12 recipients received 1–10 × 106 Treg per kg at Day +5 posttransplantation lieu of induction (Treg Therapy cohort). Nineteen patients standard (Reference Primary were...
We and others have previously described signatures of tolerance in kidney transplantation showing the differential expression B cell–related genes relative expansions cell subsets. However, all these studies, index group—namely, tolerant recipients—were not receiving immunosuppression (IS) treatment, unlike rest comparator groups. aimed to assess confounding effect regimens develop a novel IS-independent signature tolerance. Analyzing gene three independent transplant patient cohorts (232...
The pathogenesis and natural history of HIV-associated immune complex kidney disease (HIVICK) is not well understood. Key questions remain unanswered, including the role HIV infection replication in development efficacy antiretroviral therapy (ART) prevention treatment disease. In this multicentre study, we describe renal pathology HIVICK compare clinical characteristics patients with those IgA nephropathy (HIVAN). Poisson regression models were used to identify risk factors for each these...
Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN) is an important cause of end-stage renal disease among African American patients. This study was performed to the epidemiology HIVAN in a predominantly black population and impact highly active antiretroviral therapy other factors on development disease.
Summary Background and objectives Cell-based therapy with natural (CD4 + CD25 hi CD127 lo ) regulatory T cells to induce transplant tolerance is now technically feasible. However, from hemodialysis patients awaiting transplantation may be functionally/numerically defective. Human are also heterogeneous, some able convert proinflammatory Th17 cells. This study addresses the suitability of for cell-based in preparation first clinical trials renal recipients (the ONE Study). Design, setting,...
What's known on the subject? and What does study add? Previously, donors with asymptomatic stones found incidentally CT were not considered ideal donor candidates because of presumed risk morbidity to both recipient. Increasingly, studies show that these risks are low. This aims evaluate long‐term safety using ex vivo ureteroscopy remove from kidney bench before donation. Outcomes so far suggest this technique can safely render a stone‐free transplantation. has led 20 more transplants in our...
3% of kidney transplant recipients return to dialysis annually upon allograft failure. Development antibodies (Ab) against human leukocyte antigens (HLA) is a validated prognostic biomarker We tested whether screening for HLA Ab, combined with an intervention improve adherence and optimization immunosuppression could prevent failure.Prospective, open-labelled randomised biomarker-based strategy (hybrid) trial in 13 UK centres [EudraCT (2012-004308-36) ISRCTN (46157828)]. Patients were...
HIV-positive patients are at increased risk of end-stage kidney disease (ESKD). Kidney transplantation (KT) is an established treatment modality for ESKD in the general population. Recent data have confirmed feasibility patients, and increasingly offered to with well-controlled HIV infection. We report clinical outcomes a national cohort study patients. In all, 35 KT recipients who had undergone up December 2010 (66% male, 74% black ethnicity) were identified; median CD4 cell count was 366,...
Asymptomatic bacteriuria is frequent in kidney transplant recipients (KTRs). However, there no consensus on diagnosis or management. We conducted a European survey to explore current practice related the and management of asymptomatic adult KTRs.A panel experts from Renal Association-European Dialysis Transplant Association/Developing Education Science Care for Transplantation States working group Study Group Infections Compromised Hosts Society Clinical Microbiology Infectious Diseases...
In Brief Background Kidney transplantation (KT) of human immunodeficiency virus (HIV)–positive patients has transformed the management end-stage kidney disease in this population. Although favourable outcomes have been reported, experience high rates acute allograft rejection (AR). We examined factors associated with AR first year after KT, particular emphasis on choice calcineurin inhibitor (CNI) immunosuppressive therapy. Methods conducted a national observational cohort study HIV/KT...
Improvement in long-term renal allograft survival is impeded by incomplete or erroneous coding of causes loss. This study reports 13-year trends graft failure across the UK. National Health Service Blood and Transplant (NHSBT) UK Renal Registry data were linked to describe kidney patients transplanted 2000–13. NHSBT categories used, with 'other' recoded when free text was available. Adjusted analyses examined influence age, ethnicity donor type on failure. In 22 730 recipients, 5389 (23.7%)...
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Cancer transmission is a known risk for recipients of organ transplants. Many people wait long time suitable transplant; some never receive one. Although patients with brain tumors may donate their organs, opinions vary on the risks involved.To determine cancer associated transplants from deceased donors primary tumors. Key secondary objectives were to investigate association that donor have usage and posttransplant survival.This was cohort study in England Scotland, conducted January 1,...
Peripancreatic fluid collections (PPFC) are a serious complication after simultaneous pancreas-kidney transplantation (SPKTx).Retrospective study for all 223 SPKTx performed from December 8, 1996, to October 10, 2011, evaluate the risk factors (RF) and impact of PPFCs on outcomes was conducted.Clinically significant were seen in 36 (16%) cases, within 3 months transplantation. Radiologic drainage resolved 2 (6%) 34 required laparotomy (mean [SD], 4 [7]). Compared with non-PPFC group (n=186),...
Studies assessing cardiovascular disease (CVD) risk factors in patients with psoriasis have been limited by selection bias, inappropriate controls or a reliance on data collected for clinical reasons.To investigate whether screening CVD primary care augments the known prevalence of cross-sectional study.Patients listed as having were recruited, screened and assessed QRISK2.In total, 287 attended (mean age 53 years, 57% women, 94% white British, 22% severe disease, 33% self-reported psoriatic...
It has been suggested that the research priorities of those funding and performing in transplantation may differ from end service users such as patients, carers healthcare professionals involved day-to-day care. The Kidney Transplant Priority Setting Partnership (PSP) was established with aim involving all stakeholders prioritising future field.The PSP methodology is outlined by James Lind Alliance. An initial survey collected unanswered questions clinicians. Duplicate out-of-scope topics...
Abstract Background and hypothesis Starting dialysis is associated with morbidity mortality. Outcomes for people failed transplants can be poorer than native kidney failure. We aimed to determine if modality, place of initiation, mortality outcomes differed in the first 90 days between starting transplant Methods Retrospective cohort using linked UK Renal Registry (UKRR) data Hospital Episode Statistics. Modality, compared day 16,417 adults England January 2018 December 2019. Results...
Background. Nephropathy associated with BK virus (BKVAN) has recently emerged as an important cause of allograft failure following renal transplantation. The aim this study was to evaluate the effectiveness laboratory markers in follow-up patients BKVAN.
Introduction: For suitable patients, renal transplantation is considered the optimal modality of replacement therapy, with availability donor organs limiting number transplants undertaken. The 2006 kidney allocation policy was developed to ensure equity patients on transplant waiting list, whilst still achieving a good donor/recipient match. This study aims describe characteristics list and variations in median times. Methods: Demographics clinical all listed for only UK 1st January 2011...