A5009223204- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Immunodeficiency and Autoimmune Disorders
- Porphyrin Metabolism and Disorders
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Intensive Care Unit Cognitive Disorders
- Hereditary Neurological Disorders
- Phonocardiography and Auscultation Techniques
- Syphilis Diagnosis and Treatment
- Chemical Analysis and Environmental Impact
- Rabies epidemiology and control
- Complementary and Alternative Medicine Studies
- Diabetes Treatment and Management
- CNS Lymphoma Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Insect and Pesticide Research
University of Toronto
2025
Sinai Hospital
2025
Children's Hospital of Eastern Ontario
2025
University of Ottawa
2025
Ottawa Hospital
2025
University College London
2019-2024
Mortimer Market Centre
2019-2024
Central and North West London NHS Foundation Trust
2019-2024
Eastern Health
2024
National Institute for Health Research
2024
Objective: Excessive weight gain has been reported with integrase strand transfer inhibitors (INSTIs). We evaluated changes in virologically suppressed adults HIV who switched from non-INSTI regimens to raltegravir (RAL)-containing or dolutegravir (DTG)-containing antiretroviral therapy. Design: Retrospective single-centre cohort. Methods: Adults RAL DTG before between January 2015 and October 2017 were identified. Virologically suppressed, treatment-experienced (≥2 years) individuals, at...
Abstract Plasma hexachlorobenzene (HCB) residues in a Louisiana population exposed through the transportation and disposal of chemical waste containing HCB averaged 3.6±4.3 parts per billion (ppb) sample 86 people. The highest level was 345 ppb facility worker while general 23 ppb. There no evidence cutaneous porphyria by history or skin examination. Males had significantly higher than females (4.71 vs 2.79 ppb) but there were age differences. A possible association between coproporphyrin...
Hexachlorobenzene (HCB) blood residues were found in 19 of 20 vegetable spraymen exposed to HCB-contaminated dimethyl-1-2, 3, 5, 6-tetrachloroterephthalate (DCPA). The mean level was 40 ± 63 parts per billion (ppb) with a range 0 310 ppb. No definite physical or biochemical effects this exposure discovered. Specifically there no evidence cutaneous porphyria abnormalities uroporphyrin coproporphyrin excretion. A positive correlation (P<.05) for HCB levels and δ-aminolevulinic acid excretion...
Variants of the
Chronic kidney disease (CKD) is a leading cause of morbidity and mortality globally. The risk CKD increased in people African ancestry with Human Immunodeficiency Virus (HIV) infection.
Metabolic dysfunction associated fatty liver disease (MAFLD) is over-represented in people with HIV (PWH). Maraviroc (MVC) and/or metformin (MET) may reduce MAFLD by influencing inflammatory pathways and acid metabolism.
Congenital cytomegalovirus (CCMV) accounts for high rates of infant morbidity and mortality. Neutropenia is a common finding in CCMV infection, which the age presentation overlaps with autoimmune neutropenia (AIN). AIN represents one most forms chronic childhood.A literature search exploring biologic associations between was conducted: PubMed (MEDLINE), Ovid Web Science. We further describe 2 cases concurrent AIN. Both were confirmed indirect granulocyte immunofluorescence test alternative...
Abstract Objectives Integrase strand transfer inhibitors (INSTIs) are commonplace in modern antiretroviral therapy (ART). Increased weight gain with their use is increasingly scrutinized. We evaluated changes treatment‐naïve adults HIV‐1 attending a UK centre who started regimens including raltegravir or dolutegravir. Methods A retrospective cohort study of prescribed an INSTI between January 2015 and March 2020 were categorized as having ART regimen containing raltegravir, dolutegravir,...
Objective: Bone loss in people with HIV (PWH) is poorly understood. Switching tenofovir disoproxil fumarate (TDF) to alafenamide (TAF) has yielded bone mineral density (BMD) increases. PETRAM (NCT#:03405012) investigated whether BMD and turnover changes correlate. Design: Open-label, randomized controlled trial. Setting: Single-site, outpatient, secondary care. Participants: Nonosteoporotic, virologically suppressed, cis-male PWH taking TDF/emtricitabine (FTC)/rilpivirine (RPV) for more than...
: The association between human immunodeficiency virus (HIV) and lymphoma was observed early in the HIV epidemic 1980s. Lymphoma incidence remains significantly higher than general population. Previously people living with (PLWH) had advanced immune suppression, organ dysfunction consequently poor performance status (PS). advent of combination antiretroviral therapy (ART) has led to improved reconstitution enhanced outlook PLWH, influenced subtypes tolerability treatment. However still most...
Sickle cell trait (SCT) has been associated with chronic kidney disease (CKD) in African Americans, although evidence for its impact Africans and people HIV is currently lacking. We conducted a cross-sectional study investigating the association between SCT of ancestry UK.
Objectives Rapid initiation of antiretroviral therapy (ART) is important for individuals with high baseline viral loads, such as in primary HIV‐1 infection (PHI). Four‐drug regimens are sometimes considered; however, data lacking on tolerability. We aimed to evaluate the tolerability four‐drug used Research Viral Eradication Reservoirs (RIVER) study. Methods At enrolment, ART‐naïve adult participants or those newly commenced ART were initiated intensified within 4 weeks PHI. start was...
Oxidative stress has been implicated in the pathogenesis and progression of chronic kidney disease (CKD). An imbalance between increased production reactive oxygen species reduced antioxidant defenses results disruption to downstream cellular signaling subsequent renal cell apoptosis senescence, fibrosis, vascular injury.1Duni A. Liakopoulos V. Roumeliotis S. et al.Oxidative evolution disease: untangling Ariadne's thread.Int J Mol Sci. 2019; 20https://doi.org/10.3390/ijms20153711Crossref...
Congenital enterovirus infection can be associated with a pro‐inflammatory state triggering haemophagocytic lymphohistiocytosis (HLH). Enteroviruses are also known to cause transient neutropenia in healthy children. Two infants presented temperature instability, lethargy, thrombocytopaenia, hepatosplenomegaly and evidence of hyperinflammation the setting perinatal maternal rash household contacts gastrointestinal symptoms. Whilst HLH was successfully treated both, protracted persisted....
Abstract Background Blood management is an important aspect of healthcare and vital for the well-being patients. For effective blood management, it essential to determine quality documentation processes transfusions in Electronic Medical Records (EMR) system. The EMR system stores information on most activities performed a digital hospital. As such, difficult get overview all data. National Safety Quality Health Service (NSQHS) Standards define metrics that assess care health entities such...