A5028391604- HIV-related health complications and treatments
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 detection and testing
- HIV Research and Treatment
- Renal Diseases and Glomerulopathies
- Ovarian function and disorders
- HIV/AIDS drug development and treatment
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Hematological disorders and diagnostics
- Sexual function and dysfunction studies
- COVID-19 epidemiological studies
- Infection Control and Ventilation
- Biosensors and Analytical Detection
- Multiple Myeloma Research and Treatments
- Advanced Chemical Sensor Technologies
- Pharmacological Effects and Toxicity Studies
- Viral gastroenteritis research and epidemiology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Transplantation Outcomes and Treatments
- RNA regulation and disease
- Infectious Diseases and Tuberculosis
University College London
1995-2021
Central and North West London NHS Foundation Trust
2019
Mortimer Market Centre
2019
North Middlesex Hospital
1995
Western Infirmary
1992
University of Glasgow
1992
Abstract Background Although SARS-CoV-2 infection in Healthcare Workers (HCWs) is a public health concern, there little description of their longitudinal antibody response the presence or absence and symptoms. We followed HCWs an acute London hospital to measure seroconversion RNA detection at peak pandemic. Methods enrolled 200 patient-facing between 26 March 8 April 2020 collected twice-weekly self-administered nose throat swabs, symptom data monthly blood samples. Swabs were tested for by...
Objective: Excessive weight gain has been reported with integrase strand transfer inhibitors (INSTIs). We evaluated changes in virologically suppressed adults HIV who switched from non-INSTI regimens to raltegravir (RAL)-containing or dolutegravir (DTG)-containing antiretroviral therapy. Design: Retrospective single-centre cohort. Methods: Adults RAL DTG before between January 2015 and October 2017 were identified. Virologically suppressed, treatment-experienced (≥2 years) individuals, at...
Abstract Background The aims of this study were to identify common patterns comorbidities observed in people living with HIV (PLWH), using a data-driven approach, and evaluate associations between identified. Methods A wide range assessed PLWH participating 2 independent cohorts (POPPY: UK/Ireland; AGEhIV: Netherlands). presence/absence each comorbidity was determined mix self-reported medical history, concomitant medications, health care resource use, laboratory parameters. Principal...
Severe renal failure is a life-threatening complication of multiple myeloma. Aggressive treatment can reverse acute in many cases but the prognosis for those who require chronic replacement therapy not clear. We have reviewed these patients Brighton, Dulwich and Guy's Hospitals units. Twenty-three were treated total 385 months. Over half presented with end-stage required dialysis immediately. Fifteen died during study period actuarial survival was 45 per cent at one year; six survived longer...
Monocytes from human immunodeficiency virus (HIV) patients have an increased heterogeneity of phenotype and function. In a study 120 HIV we demonstrated that they normal monocyte differential counts but with progression the disease increasing proportion monocytes show phenotypic functional evidence for activation or maturation. A are larger, expression CD11b, HLA-DR, CD45 CD16. Concomitantly there was TNF-α, high constitutive synthesis PGE2 plasma IL-6 levels. This suggested exist more...
The value of immunoscintigraphy with technetium-99m (99Tcm) labelled anti-granulocyte monoclonal antibody (BW250/183) was studied prospectively in human immunodeficiency virus (HIV-1) antibody-positive patients presenting fever without localizing symptoms or signs. Twenty-three studies were performed 23 and the results 99Tcm-anti-granulocyte imaging compared definitive microbiological cytological diagnosis. Twenty-one had an infective cause pyrexia, one patient disseminated lymphoma Kaposi...
A Caucasian homosexual man with AIDS and cytomegalovirus retinitis presented facial pain episodic confusion, had several seizures became obtunded. An electroencephalogram was suggestive of herpes simplex encephalitis. The diagnosis confirmed by detection virus type 2 (HSV 2), but not 1, DNA in cell-free cerebrospinal fluid (CSF) after amplification nested polymerase chain reaction. patient also evidence concomitant (CMV) infection detectable CMV CSF. With high-dose acyclovir the recovered....
We examined follicle-stimulating hormone (FSH) levels in women living with HIV aged > 45 reporting ≥ 12 months' amenorrhoea, and investigated correlation menopausal symptoms.A cross-sectional substudy of 85 from the Positive Transitions through Menopause (PRIME) Study who reported irregular periods at entry into PRIME amenorrhoea recruitment this substudy. Serum FSH was supplemented clinical data symptom assessment. 30 mIU/mL defined as consistent postmenopausal status. Associations between...
A monoclonal antibody, P1, possessing anti-glomerular basement membrane specificity similar to that of naturally-occurring Goodpasture was used study renal biopsy material from patients with thin-membrane nephropathy. Immunofluorescence and immunoperoxidase techniques were employed detect tissue localisation after sections had been incubated P1. Staining glomerular tubular membranes in the 14 nephropathy 10 subjects various other diseases, whereas three Alport's syndrome all gave diminished...
Prvulovich, E.1; Miller, R. F.2; Costa, D. C.1; Severn, A.2; Corbett, E.2; Bomanji, J.1; Becker, W.3; Ell, P. J.1 Author Information