A5038047002- Drug-Induced Adverse Reactions
- Appendicitis Diagnosis and Management
- Pharmacovigilance and Adverse Drug Reactions
- Respiratory and Cough-Related Research
- Contact Dermatitis and Allergies
- Renal Diseases and Glomerulopathies
- Cardiac, Anesthesia and Surgical Outcomes
- Diverticular Disease and Complications
- Urticaria and Related Conditions
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Sepsis Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Food Allergy and Anaphylaxis Research
- Antimicrobial Resistance in Staphylococcus
- Chronic Lymphocytic Leukemia Research
- Hematological disorders and diagnostics
- Historical Medical Research and Treatments
- Phytochemical and Pharmacological Studies
- Streptococcal Infections and Treatments
- Mycobacterium research and diagnosis
- Moringa oleifera research and applications
- Intestinal Malrotation and Obstruction Disorders
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
Leeds Teaching Hospitals NHS Trust
2005-2025
University of Leeds
2013-2025
Lehigh Valley Hospital-Pocono
2023
Lehigh Valley Health Network
2023
Security Forces Hospital
2022
Leeds General Infirmary
2019-2021
Background About 6% of the UK general practice population has a record penicillin allergy but fewer than 10% these people are likely to be truly allergic. Consequently, significant portion is denied first line antibiotics. The ALABAMA trial aimed determine if assessment pathway (PAAP) was safe and effective in de-labelling patients as allergic improving antibiotic prescribing patient health outcomes. Aims To investigate patients’ experience testing (PAT) their acceptance following negative...
Background: Eosinophilic Granulomatosis with Polyangiitis (EGPA), formerly known as Churg-Strauss Syndrome, is a rare autoimmune vasculitis affecting small- and medium-sized blood vessels. It characterized by multisystem involvement, including respiratory, dermatological, neurological manifestations. Neurological complications, such mononeuritis multiplex peripheral neuropathy, are reported in up to 70% of cases can result significant functional impairment. Standard treatments,...
Background Penicillin allergy (PenA) prevalence is approximately 6%, but fewer than 10% of these people are expected to be truly allergic. Consequently, a significant proportion the population prescribed alternative antibiotics with potential increased risk acquiring multi-drug resistant bacteria and worse health outcomes. The ALABAMA trial aimed determine if penicillin assessment pathway (PAAP) initiated in primary care, effective de-labelling erroneous records, improving antibiotic...
Incorrect penicillin allergy records are recognised as an important barrier to the safe treatment of infection and affect estimated 2.7 million people in England. Penicillin associated with worse health outcome antimicrobial resistance. The ALlergy AntiBiotics And Microbial resistAnce (ALABAMA) trial aims determine if intervention package, centred around a assessment pathway (PAAP) initiated primary care, is effective improving patient outcomes antibiotic prescribing. ALABAMA multicentre,...
Abstract We examine 3 different approaches to protecting the gut microbiome: highly targeted antibiotics, antibiotic destruction, and binding. Each approach shows promise prevent off-target effects of antibiotics on microbiome.
Abstract Background Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. The aim of this study was to describe the clinical characteristics patients cIAI in a multicentre develop prediction models (CPMs) help identify at risk mortality or relapse. Methods A observational conducted from August 2016 February 2017 UK. Adult diagnosed were included. Multivariable logistic regression performed CPMs for c-statistic used test model discrimination....
Oxidative stress has been implicated in the pathogenesis and progression of chronic kidney disease (CKD). An imbalance between increased production reactive oxygen species reduced antioxidant defenses results disruption to downstream cellular signaling subsequent renal cell apoptosis senescence, fibrosis, vascular injury.1Duni A. Liakopoulos V. Roumeliotis S. et al.Oxidative evolution disease: untangling Ariadne's thread.Int J Mol Sci. 2019; 20https://doi.org/10.3390/ijms20153711Crossref...
Moringa oleifera, also known as the miracle tree, is considered nutritionally rich with therapeutic properties. This article emphasizes phytochemicals and their potential in management of Type II diabetes. study aims to provide a comprehensive understanding oleifera’s contributions Nowadays, attention has been drawn towards for its manage oxidative stress inflammation associated In this review article, we included various scientific studies establish link between effect moringa extracts on...
Use of electronic health records (EHR) to provide real-world data for research is established, but using EHR deliver randomised controlled trials (RCTs) more efficiently less developed. The Allergy AntiBiotics And Microbial resistAnce (ALABAMA) RCT evaluated a penicillin allergy assessment pathway versus usual clinical care in UK primary setting. aim this paper describe how EHRs were used facilitate efficient delivery large-scale trial complex intervention embracing participant...
An experimentallrial was callied out althe Experimental Farm of Sakha Agric.Res.Stalion during two seasons (1999/2000 and 2000101) to study the effect FYM planting space on Ammi v/snaga l .plants.FYM used at rale 15. 20 25 m 3 /fed.Which were added before preparation experimental field spaces 20, 30 cm.The data showed that, using ml lfed.FYM Significantly Increased vegetative growth, by Increasing up em apart growth increased. .TreaUng plants with different rates increased seed we{ght per...
Abstract Background Antibiotic consumption is one of the main drivers for antimicrobial resistance (AMR). To improve clinical outcomes and tackle AMR, we need to antibiotic usage in patients with penicillin allergy (PenA). Patients PenA have been found higher usage, often requiring repeated courses antibiotics compared those without PenA. Additionally, are more likely receive broad spectrum antibiotics. Objectives determine whether who be colonized or infected resistant bacteria. Methods...
Introduction: We report an eight-case series of coronavirus disease 2019 (COVID-19)-related multisystem inflammatory syndrome in children (MIS-C). Methods: Children who tested positive for COVID-19, met the MIS-C criteria World Health Organization (WHO), and were hospitalized at a tertiary hospital Riyadh from September to December 2021 identified their clinical data reviewed. Results: The age diagnosis is between 4 13 years old. Fever, decreased oral intake, gastroenteritis, abdominal pain...
Abstract Introduction Complicated intra-abdominal infections (cIAI) pose a major challenge in surgical patients. Despite the heterogenous aetiology they have common disease process, which is bacterial infection of peritoneal space. Hence, all cIAIs are managed with source control, plus antibiotic therapy. However, there uncertainty regarding optimal treatment strategy order to prevent relapse or extra-abdominal spread infection1. At present, no UK guidance on management cIAIs2. For other...