A5066019954- Pelvic floor disorders treatments
- Clostridium difficile and Clostridium perfringens research
- Economic and Technological Innovation
- Anorectal Disease Treatments and Outcomes
- Gut microbiota and health
- Economic Growth and Productivity
- Innovation and Socioeconomic Development
- Ureteral procedures and complications
- Labor market dynamics and wage inequality
- Urinary Bladder and Prostate Research
- Microscopic Colitis
- SARS-CoV-2 detection and testing
- Dental Education, Practice, Research
- Antibiotic Resistance in Bacteria
- Urological Disorders and Treatments
- Pelvic and Acetabular Injuries
- SARS-CoV-2 and COVID-19 Research
- Mycobacterium research and diagnosis
- Education Systems and Policy
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Sexual function and dysfunction studies
- Income, Poverty, and Inequality
- Connective tissue disorders research
- Infection Control and Ventilation
Leeds Teaching Hospitals NHS Trust
2018-2024
University of Leeds
2016-2024
NIHR Leeds Musculoskeletal Biomedical Research Unit
2023
Cornell University
2022
Leeds General Infirmary
2020-2021
Chapel Allerton Hospital
2020
University of Cape Town
2017
Summa Health System
2012
Northeast Ohio Medical University
2012
Good Samaritan Hospital
2005-2008
Nosocomial transmission of SARS-CoV-2 is a key concern, and evaluating the effect testing infection prevention control strategies essential for guiding policy in this area. Using within-hospital SEIR transition model typical English hospital, we estimate that between 9 March 2020 17 July approximately 20% infections inpatients, 73% healthcare workers (HCWs) were due to nosocomial transmission. Model results suggest placing suspected COVID-19 patients single rooms or bays has potential reduce...
In Brief OBJECTIVE: To evaluate the five-year anatomic and functional outcomes of high uterosacral vaginal vault suspension. METHODS: One hundred ten patients with advanced symptomatic uterovaginal or posthysterectomy prolapse treated between January 1997 2000 were identified 72 (65%) consented to participate in this study. Anatomic obtained by Pelvic Organ Prolapse Quantification. Functional results subjectively quality-of-life questionnaires, including short-form Incontinence Impact...
This work aimed to resolve the conflicting reports on Prevotellaceae abundance in development of rheumatoid arthritis (RA) and observe structural, functional temporal changes gut microbiome RA progressors versus non-progressors.
In Brief OBJECTIVE: To develop a valid and reliable tool to objectively measure surgical skill necessary for repair of fourth-degree perineal lacerations then use this improvement after workshop. METHODS: We measured baseline ability clinical knowledge 26 residents (postgraduate year [PGY]-1 PGY-4) using the Objective Structured Assessment Technical Skills (OSATS) written examination. The OSATS consists global skills assessment (OSATS-G), procedure checklist (OSAT-C), pass/fail grade. Five...
Abstract Objective Individuals with newly diagnosed RA have a distinct microbiome when compared healthy controls. However, little is known as to these perturbations begin. Using prospective at-risk cohort of individuals positive for anti-citrullinated protein (anti-CCP) antibody new onset musculoskeletal symptoms, but without clinical arthritis, we investigated the presence gut dysbiosis before RA. Methods The microbiota 25 anti-CCP synovitis were sequenced targeting V4 region 16S rRNA gene....
Carbapenemase-producing Enterobacteriaceae (CPE) pose a major global health risk. Mobile genetic elements account for much of the increasing CPE burden. To investigate colonization and impact antibiotic exposure on subsequent resistance gene dissemination within gut microbiota using model to simulate human colon. Gut models seeded with CPE-negative faeces [screened BioMérieux chromID® CARBA-SMART (Carba-Smart), Cepheid Xpert® Carba-R assay (XCR)] were inoculated distinct...
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) infections in neonates can result significant morbidity and mortality. However, comparatively to adults, neonatal MRSA data remains relatively scarce. Additionally, while evidence-driven practices for adults have seen considerable progress, infection prevention strategies remain poorly described. The Leeds Newborn Service adopted a series of control (IPC) measures following rise cases 2008–2009. This narrative review presents IPC...
In Brief BACKGROUND: Abdominal sacral colpopexy is a popular method for resupporting the vaginal apex. Bleeding and infection are most common complications. We report complication resulting in small bowel fistula. CASE: A 48-year-old woman developed chronic discharge 4–6 months after routine abdominal which velour mesh remained exposed pelvis. Conservative measures failed to control intermittent copious from upper vault where was visualized. At laparotomy, an entero fistula discovered....
Recent advances imply that early events triggering rheumatoid arthritis (RA) occur at mucosal surfaces. We aimed to evaluate whether intestinal permeability is altered in patients increased risk of RA, and/or predicts the development clinical arthritis, by measuring serum zonulin family peptides (ZFP) levels, which are shown reflect barrier integrity.