A5005491498- Orthopedic Infections and Treatments
- Inhalation and Respiratory Drug Delivery
- Orthopaedic implants and arthroplasty
- Airway Management and Intubation Techniques
- Iron Metabolism and Disorders
- Tracheal and airway disorders
- Pharmaceutical studies and practices
- Asthma and respiratory diseases
- Total Knee Arthroplasty Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Hemoglobinopathies and Related Disorders
- Central Venous Catheters and Hemodialysis
- Childhood Cancer Survivors' Quality of Life
- Herpesvirus Infections and Treatments
- Antifungal resistance and susceptibility
- Drug Transport and Resistance Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- Palliative Care and End-of-Life Issues
- Dental Research and COVID-19
- Healthcare Decision-Making and Restraints
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Plant-based Medicinal Research
- Synthesis and Biological Evaluation
Nottingham University Hospitals NHS Trust
2011-2024
Queen's Medical Centre
2006-2021
Office of Infectious Diseases
2021
University College London Hospitals NHS Foundation Trust
2020
University College London
2020
Vectura (United Kingdom)
2018-2019
Nottingham City Hospital
2009-2016
Pulmagen Therapeutics (United Kingdom)
2013
King's College School
1990-1991
MRC Clinical Trials Unit at UCL
1985-1990
Abstract Background Reporting of outpatient parenteral antimicrobial therapy (OPAT) outcomes with national benchmarking is key to informing service development and supporting quality improvement. Objectives To analyse report on data collected by the BSAC OPAT National Outcomes Registry from 2015 2019. Methods Quarterly 2020 was extracted analysed. Results 57 organizations submitted 27 841 patient episodes 442 280 treatment days. A diverse range infections antimicrobials were reported a mean...
Objective: To determine whether serial casting combined with botulinum toxin reduces the development of calf contracture after severe head injury. Design: A double-blind placebo-controlled trial three parallel treatments for lower limb spasticity. Setting: Acute general hospital in UK. Subjects: Adults aged 17–70 years admitted to following a brain Interventions: Current physical treatment (group I), leg plus injections either saline II), or III) into gastrocnemius and soleus muscles....
Aims Single-stage revision total knee arthroplasty (rTKA) is gaining popularity in treating chronic periprosthetic joint infections (PJIs). We have introduced this approach to our clinical practice and sought evaluate rates of reinfection re-revision, along with predictors failure both single- two-stage rTKA for PJI. Methods A retrospective comparative cohort study all rTKAs PJI between 1 April 2003 31 December 2018 was undertaken using prospective databases. Patients acute were excluded;...
Tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 are implicated in the pathogenesis of severe Plasmodium falciparum malaria. In this study, effect IL-10 on their production by peripheral blood mononuclear cells (PBMC) from acutely infected patients was examined. Exogenous inhibited malarial antigen-induced cytokine reducing mRNA accumulation. Maximal inhibition occurred when added first 2 h stimulation. Conversely, addition anti-IL-10 markedly enhanced TNF-alpha,...
The availability of stability data for the use continuous intravenous flucloxacillin in an elastomeric device has enabled treatment serious Methicillin Sensitive Staphylococcus aureus (MSSA) outpatient parenteral antimicrobial therapy (OPAT) setting. This service review aimed to evaluate current standard care establish clinical effectiveness and complication rates associated with its since introduction at our institution. A retrospective outcomes adverse events/complications, was undertaken...
Abstract Objectives We determined the available mechanisms to generate income from outpatient parenteral antimicrobial therapy (OPAT) in UK and calculated revenue generated treatment of an episode cellulitis. Methods Revenue was for patients receiving cellulitis as inpatient OPAT by a series different payment pathways. Selected established services Northern Ireland, Scotland Wales, where Payment-by-Results (PbR) does not operate, were contacted determine individual national funding...
Infection following total hip or knee arthroplasty is a serious complication. We noted an increase in post-operative infection cases carried out temporary operating theatres. therefore compared those performed standard and theatres examined the deep periprosthetic rates.A of 1223 primary arthroplasties were between August 2012 June 2013. A 539 (44%) The two groups matched for age, gender, body mass index American Society Anesthesiologists grade.The rate was 0 684 (0%); it eight (1.5%) (p =...
Interstitial pneumonitis is a rare complication of cytomegalovirus (CMV) infection in the immunocompetent. There paucity literature regarding treatment these patients. A previously healthy, immunocompetent female patient presented with fever, shortness breath, dry non-productive cough and myalgia was subsequently diagnosed CMV interstitial pneumonitis. She treated valganciclovir swiftly improved but experienced neutropenia, which resolved on cessation.
A 29-year-old patient with HIV developed a facial angioedema hypersensitivity reaction to aciclovir when treated for acute retinal necrosis secondary herpes virus infection. She similar famciclovir. Successful rapid desensitisation oral was performed and she became tolerant aciclovir. successfully completed 28 months of continuous treatment no further reactions. However, later experienced blurred vision resumed taking without preceding regimen. No allergic occurred.
The subcellular distribution of newly absorbed iron in isolated mouse duodenal enterocytes was investigated by analytical fractionation using sucrose density gradient centifugation. Two major peaks mucosal 59Fe activity were observed: one soluble and particulate (density 1.18-1.20 g ml-1). latter increased following prior exposure animals to chronic hypoxia. localized the basolateral membranes marker enzyme Na+, K+ activated, Mg2+ dependent, ATPase washing intact with selective plasma...
Usual culture methods to identify pathogenic bacteria can be unsuccessful, particularly when working with fastidious organisms. We present a case of early periprosthetic knee joint infection Ureaplasma parvum only identified using 16S ribosomal RNA PCR. This represents the impact molecular bacterial identification have on clinical care allowing for more targeted antimicrobial therapy; something which is imperative in an era increasing resistance.
Abstract Background Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. The aim of this study was to describe the clinical characteristics patients cIAI in a multicentre develop prediction models (CPMs) help identify at risk mortality or relapse. Methods A observational conducted from August 2016 February 2017 UK. Adult diagnosed were included. Multivariable logistic regression performed CPMs for c-statistic used test model discrimination....