A5066491567- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Transplantation: Methods and Outcomes
- Neurological Complications and Syndromes
- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Bone health and osteoporosis research
- Pharmacological Effects and Toxicity Studies
- Liver Disease and Transplantation
- Metabolism and Genetic Disorders
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- Chronic Kidney Disease and Diabetes
- Pregnancy and Medication Impact
- Complement system in diseases
- Long-Term Effects of COVID-19
- Bone and Joint Diseases
- Bone health and treatments
- Heart Failure Treatment and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
Hospital Universitario de Canarias
2012-2025
Universidad de La Laguna
2004-2025
Adventist Health Glendale
2025
Universidad Regional Autónoma de Los Andes
2025
Mexican Social Security Institute
2025
Instituto de Investigación Biomédica de Salamanca
2024
Centro de Investigación Biomédica en Red de Cáncer
2024
Pontificia Universidad Católica del Ecuador
2024
Hospital Universitario La Paz
2024
Hospital Regional Universitario de Málaga
2014-2023
Physical activity, including appropriate endurance and resistance training, is a major therapeutic modality for type 2 diabetes. Unfortunately, too often physical activity an underutilized therapy. Favorable changes in glucose tolerance insulin sensitivity usually deteriorate within 72 h of the last exercise session: consequently, regular imperative to sustain glucose-lowering effects improved sensitivity. Individuals with diabetes should strive achieve minimum cumulative total 1,000 kcal x...
We report the nationwide experience with solid organ transplant (SOT) and hematopoietic stem cell (HSCT) recipients diagnosed coronavirus disease 2019 (COVID-19) in Spain until 13 July 2020. compiled information for 778 (423 kidney, 113 HSCT, 110 liver, 69 heart, 54 lung, 8 pancreas, 1 multivisceral) recipients. Median age at diagnosis was 61 years (interquartile range [IQR]: 52-70), 66% were male. The incidence of COVID-19 SOT two-fold higher compared to Spanish general population. median...
Abstract Introduction Extracorporeal circulation induces hemostatic alterations that lead to inflammatory response (IR) and postoperative bleeding. Tranexamic acid (TA) reduces fibrinolysis blood loss after cardiopulmonary bypass (CPB). However, its effects on IR vasoplegic shock (VS) are not well known elucidating these was the main objective of this study. Methods A case control study carried out determine factors associated with CPB. Patients undergoing elective CPB surgery were randomly...
Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have cardioprotective and renoprotective effects. However, experience with SGLT2is in diabetic kidney transplant recipients (DKTRs) is limited.This observational multicentre study was designed to examine the efficacy safety of DKTRs. The primary outcome adverse effects within 6 months SGLT2i treatment.Among 339 treated DKTRs, were recorded 26%, most frequent (14%) being urinary tract infection (UTI). In 10%, suspended mostly because UTI....
Stenosis of the subclavian vein (SVS) after cannulation occurs in 15 to 50% chronic hemodialysis patients, and impedes placement an arteriovenous fistula ipsilateral arm. Its natural history pathogenic mechanisms are not well established. This study examined 42 consecutive renal failure patients (28 men 14 women; 46+/-19 yr) whom catheters had been placed as initial vascular access for hemodialysis. All underwent sequential venography studies: at baseline (24 48 h removal catheter) 1, 3, 6...
Exposure to mycophenolic acid (MPA), the primary active metabolite of mycophenolate mofetil (MMF), is correlated with therapeutic efficacy MMF but varies depending on concomitantly administered immunosuppressive drugs.A 3-month pharmacokinetic substudy prospective, randomized, multicentre, open-label Symphony study was performed. Eighty-three adult renal transplant patients received standard-dose cyclosporine, 2 g/day and corticosteroids, or daclizumab induction, corticosteroids plus...
The long-term outcomes of kidney transplantation are suboptimal because many patients lose their allografts or experience premature death. Cross-country comparisons may provide insight into factors contributing to graft failure and We evaluated the rates late death among US Spanish recipients. This is a cohort study (n = 9609) 3808) who received deceased donor transplant in 1990, 1994, 1998 2002 had functioning allograft 1 year after with follow-up through September 2006. Ten-year overall...
Prolonged-release tacrolimus was developed to provide a more convenient once-daily dosing that could improve patient adherence. We conducted multicenter, prospective, observational, 12-month study describe the efficacy, safety and preference of conversion from twice-daily formulation in stable kidney transplant recipients routine clinical practice. Conversion made on 1 mg: mg basis (1 1.1 patients with trough levels <6 ng/mL). The included 1832 (mean age (± SD): 50.0 ± 13.4 years; 62.7%...
The prognostic factors and optimal therapy for invasive pulmonary aspergillosis (IPA) after kidney transplantation (KT) remain poorly studied. We included in this multinational retrospective study 112 recipients diagnosed with probable (75.0% of cases) or proven (25.0%) IPA between 2000 2013. median interval from to diagnosis was 230 days. Cough, fever, expectoration were the most common symptoms at presentation. Bilateral involvement observed 63.6% cases. Positivity rates galactomannan...
The SARS-CoV-2 (Covid-19) coronavirus pandemic is evolving very quickly and means a special risk for both immunosuppressed comorbid patients. Knowledge about this growing infection also increasing although many uncertainties remain, especially in the kidney transplant population. This manuscript presents proposal action with general specific recommendations to protect prevent vulnerable population such as recipients.
Background. Coronavirus infectious disease 2019 (COVID-19) pandemic has posed at risk the kidney transplant (KT) population. We describe clinical pictures, factors for death, and chances to recovery in a large cohort of KT recipients with COVID-19. Methods. Inclusion Spanish prospectively filled registry was allowed cases confirmed Outcomes were assessed as in-hospital mortality or recovery. Results. The study population comprised 414 patients. Fever, respiratory symptoms, dyspnea most...
The SARS-CoV-2 (Covid-19) coronavirus pandemic is evolving very quickly and means a special risk for both immunosuppressed comorbid patients. Knowledge about this growing infection also increasing although many uncertainties remain, especially in the kidney transplant population. This manuscript presents proposal action with general specific recommendations to protect prevent vulnerable population such as recipients. La pandemia por está evolucionando de manera muy rápida y representa un...
Antiviral prophylaxis is recommended in cytomegalovirus (CMV)-seropositive kidney transplant (KT) recipients receiving antithymocyte globulin (ATG) as induction. An alternative strategy of premature discontinuation after CMV-specific cell-mediated immunity (CMV-CMI) recovery (immunoguided prevention) has not been studied. Our aim was to determine whether it effective and safe discontinue when CMV-CMI detected continue with preemptive therapy.In this open-label, noninferiority clinical trial,...