Rafael Badenes
A5009929703- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury Research
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Optical Imaging and Spectroscopy Techniques
- Organ Donation and Transplantation
- Intraoperative Neuromonitoring and Anesthetic Effects
- Trauma and Emergency Care Studies
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Organ Transplantation Techniques and Outcomes
- Long-Term Effects of COVID-19
- S100 Proteins and Annexins
- Anesthesia and Pain Management
- Mechanical Circulatory Support Devices
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
Hospital Clínico Universitario de Valencia
2016-2025
Universitat de València
2016-2025
INCLIVA Health Research Institute
2016-2024
Universitat Politècnica de València
2024
Fondazione IRCCS Istituto Neurologico Carlo Besta
2024
University of Milano-Bicocca
2024
Ospedale Policlinico San Martino
2024
Nantes Université
2024
Inserm
2023
Centre de recherche en Epidémiologie et Santé des Populations
2023
<h3>Importance</h3> There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internationally within countries. <h3>Objective</h3> To formulate a consensus statement recommendations on determination BD/DNC based review the literature expert opinion large multidisciplinary, international panel. <h3>Process</h3> Relevant professional societies were recruited to develop regarding BD/DNC. Literature searches Cochrane,...
Importance Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective To assess the impact on neurological outcome of 2 different thresholds guide red blood cell Design, Setting, and Participants Multicenter, phase 3, parallel-group, investigator-initiated, pragmatic, open-label randomized clinical trial conducted 72 intensive care units across 22 countries. Eligible had...
Abstract Background Alternative noninvasive methods capable of excluding intracranial hypertension through use transcranial Doppler (ICP tcd ) in situations where invasive cannot be used or are not available would useful during the management acutely brain-injured patients. The objective this study was to determine whether ICP can considered a reliable screening test compared reference standard method, monitoring i ), presence hypertension. Methods This prospective, international,...
Abstract Background Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values partial pressure (PaO 2 ) and episodes hypoxemia hyperoxemia occurring within first 72 h mechanical ventilation out hospital (OHCA) patients. secondary evaluate association PaO with patients’ outcome. Methods Preplanned analysis targeted hypothermia versus normothermia OHCA (TTM2) trial. Arterial blood gases were collected from...
The use of processed electroencephalography (pEEG) for depth sedation (DOS) monitoring is increasing in anesthesia; however, how to this type critical care adult patients within the intensive unit (ICU) remains unclear.A multidisciplinary panel international experts consisting 21 clinicians involved DOS ICU was carefully selected on basis their expertise neurocritical and neuroanesthesiology. Panelists were assigned four domains (techniques [EEG] monitoring, patient selection, EEG monitors,...
The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. aim of this study was to describe the applied first 72 h mechanical ventilation out-of-hospital 6-month outcomes. Preplanned sub-analysis Target Temperature Management-2 trial. Clinical outcomes were mortality functional status (assessed by Modified Rankin Scale) 6 months randomization. A total 1848 included (mean age 64 [Standard Deviation, SD = 14] years). At months, 950...
The use of arterial partial pressure carbon dioxide (PaCO2) as a target intervention to manage elevated intracranial (ICP) and its effect on clinical outcomes remain unclear. We aimed describe targets for PaCO2 in acute brain injured (ABI) patients assess the occurrence abnormal values during first week intensive care unit (ICU). secondary aim was association with in-hospital mortality. carried out analysis multicenter prospective observational study involving adult invasively ventilated...
Abstract Background The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data available to provide optimal care in this scenario and worldwide variability clinical practice has been documented recent studies. Methods A multidisciplinary consensus panel physicians selected for their established scientific expertise the acute tSCI different specializations was established. World Society Emergency Surgery (WSES) European Association...
Abstract Age-associated myometrial dysfunction can prompt complications during pregnancy and labor, which is one of the factors contributing to 7.8-fold increase in maternal mortality women over 40. Using single-cell/single-nucleus RNA sequencing spatial transcriptomics, we have constructed a cellular atlas aging myometrium from 186,120 cells across twenty perimenopausal postmenopausal women. We identify 23 cell subpopulations, including contractile venous capillary as well immune-modulated...
Abstract Background There are no specific generally accepted therapies for the coronavirus disease 2019 (COVID-19). The full spectrum of COVID-19 ranges from asymptomatic to mild respiratory tract illness severe pneumonia, acute distress syndrome (ARDS), multisystem organ failure, and death. efficacy corticosteroids in viral ARDS remains unknown. We postulated that adjunctive treatment established caused by with intravenous dexamethasone might change pulmonary systemic inflammatory response...
Abstract Maintaining an adequate level of sedation and analgesia plays a key role in the management traumatic brain injury (TBI). To date, it is unclear which drug or combination drugs most effective achieving these goals. Ketamine agent with attractive pharmacological pharmacokinetics characteristics. Current evidence shows that ketamine does not increase may instead decrease intracranial pressure, its safety profile makes reliable tool prehospital environment. In this point view, we...
Abstract Background Although blood transfusions can be lifesaving in severe hemorrhage, they also have potential complications. As anemia has been associated with poor outcomes critically ill patients, determining an optimal transfusion trigger is a real challenge for clinicians. This even more important patients acute brain injury who were not specifically evaluated previous large randomized clinical trials. Neurological may particularly sensitive to anemic hypoxia because of the exhausted...