A5063181390- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Emergency and Acute Care Studies
- Acute Kidney Injury Research
- Palliative Care and End-of-Life Issues
- Family and Patient Care in Intensive Care Units
- Anesthesia and Sedative Agents
- Immune Response and Inflammation
- Trauma Management and Diagnosis
- Transplantation: Methods and Outcomes
- Antibiotic Use and Resistance
- Airway Management and Intubation Techniques
- Muscle and Compartmental Disorders
- Tracheal and airway disorders
- Psychotherapy Techniques and Applications
- Dialysis and Renal Disease Management
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Organ Transplantation Techniques and Outcomes
- Thermal Regulation in Medicine
King's College Hospital NHS Foundation Trust
2013-2025
King's College Hospital
2015-2024
Université Claude Bernard Lyon 1
2020-2022
King's College London
2019-2022
Assistance Publique – Hôpitaux de Paris
2021-2022
Alberta Health Services
2022
University of Alberta
2022
The University of Queensland
2022
University of Leeds
2020-2022
Hôpital Bichat-Claude-Bernard
2022
Studies in animals and vitro phase 2 studies humans suggest that statins may be beneficial the treatment of acute respiratory distress syndrome (ARDS). This study tested hypothesis with simvastatin would improve clinical outcomes patients ARDS.In this multicenter, double-blind trial, we randomly assigned (in a 1:1 ratio) an onset ARDS within previous 48 hours to receive enteral at dose 80 mg or placebo once daily for maximum 28 days. The primary outcome was number ventilator-free days day...
Ultrasound for diagnostic and procedural purposes is becoming a standard in daily clinical practice including anaesthesiology peri-operative medicine. The project of European Society Anaesthesiology (ESA) Task Force the development guidelines on PERioperative uSE Ultra-Sound (PERSEUS) has focused use ultrasound two areas that account majority procedures performed routinely operating room: vascular access regional anaesthesia. Given extensive literature available these areas, this paper will...
Abstract Background Sedation is often provided to resuscitated out‐of‐hospital cardiac arrest (OHCA) patients tolerate post‐cardiac care, including temperature management. However, the evidence of benefit or harm from routinely administered deep sedation after limited. The aim this trial investigate effects continuous compared minimal on patient‐important outcomes in OHCA a large clinical trial. Methods SED‐CARE part 2 × factorial Sedation, Temperature and Pressure Cardiac Arrest...
Donation-after-Determination-of-Cardiac-Death (DDCD) donor lungs can potentially increase the pool of available for Lung Transplantation (LTx). This paper presents 5-year results Maastricht category III DDCD LTx undertaken by multicenter Australian National Collaborative. The Collaborative was developed to facilitate interaction with Organ Donation Authority, standardization definitions, guidelines, education and audit processes. Between 2006 2011 there were 174 actual donors (with an...
Abstract Background Acute kidney injury (AKI) is common among patients hospitalised with COVID-19 and associated worse prognosis. The aim of this study was to investigate the epidemiology, risk factors outcomes AKI in a large UK tertiary centre. Methods We analysed data consecutive adults admitted laboratory-confirmed diagnosis across two sites hospital London, UK, from 1st January 13th May 2020. Results Of 1248 inpatients included, 487 (39%) experienced (51% stage 1, 13% 2, 36% 3). weekly...
The use of processed electroencephalography (pEEG) for depth sedation (DOS) monitoring is increasing in anesthesia; however, how to this type critical care adult patients within the intensive unit (ICU) remains unclear.A multidisciplinary panel international experts consisting 21 clinicians involved DOS ICU was carefully selected on basis their expertise neurocritical and neuroanesthesiology. Panelists were assigned four domains (techniques [EEG] monitoring, patient selection, EEG monitors,...
Phaeochromocytoma [corrected] crisis is an endocrine emergency associated with significant mortality. There little published guidance on the management of phaeochromocytoma crisis. This clinical practice update summarizes relevant literature, including a detailed review cases in past 5 years, and proposed classification system. We recommended use alpha-blockade, which strongly survival Mechanical circulatory supportive therapy (including intra-aortic balloon pump or extra-corporeal membrane...
Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but lacked an in-depth analysis of the drivers death most critically ill patients. We performed immunophenotyping viral antigen-specific and unconventional T cell responses, neutralizing antibodies, serum proteins patients with SARS-CoV-2 infection, using influenza SARS-CoV-2-convalescent health care workers, healthy adults as controls. identify mucosal-associated invariant (MAIT)...
The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show that a key characteristic fatal outcomes with 2019 (COVID-19) is the response SARS-CoV-2 spike protein enriched for antibodies directed against shared beta-coronaviruses lower proportion targeting more protective variable regions spike. magnitude antibody full-length protein, its domains subunits,...
Objectives: To assess the relationship between microcirculatory perfusion and multiple organ dysfunction syndrome in patients following traumatic hemorrhagic shock. Design: Multicenter prospective longitudinal observational study. Setting: Three U.K. major trauma centers. Patients: Fifty-eight intubated ventilated with Interventions: Sublingual incident dark field microscopy was performed within 12 hours of ICU admission (D0) repeated 24 48 later. Cardiac output assessed using oesophageal...
Invasive pulmonary aspergillosis is a complication of severe COVID-19, with regional variation in reported incidence and mortality. We describe the incidence, risk factors mortality associated COVID-19-associated (CAPA) prospective, multicentre UK cohort.
ABSTRACT During an infection, the coordinated orchestration of many factors by invading organism is required for disease to be initiated and progress. The elucidation processes involved critical development a clear understanding host-pathogen interactions. For Candida species, inactivation fungal attributes has been shown result in attenuation. Here we demonstrate that glabrata homolog Saccharomyces cerevisiae transcription factor gene ACE2 encodes function mediates virulence novel way....
There are widespread concerns about communication and support for patients families, especially when they face clinical uncertainty, a situation most marked in intensive care units (ICUs). Therefore, we aimed to develop evaluate an interventional tool improve palliative care, using the ICU as example of where this is difficult. Our design was phase I-II study following Medical Research Council Guidance Development Evaluation Complex Interventions (Methods Researching End-of-life Care...
To evaluate the feasibility and effectiveness of an information pack, based on self-regulation theory, designed to support patients their families immediately before, during after discharge from intensive care unit (ICU).
The primary objects of the investigation described in this paper were two number: (1) to examine reasons for which patients may be referred by a general practitioner his consultant and specialist colleagues ; (2) discover what functions are most required patient doctor from hospital service. Analysis results has not only answered these questions, it also provided further evidence high incidence psychoneurosis stress disorders. This study was based on single practice.
The clinical effectiveness of neurally adjusted ventilatory assist (NAVA) has yet to be demonstrated, and preliminary studies are required. study aim was assess the feasibility a randomized controlled trial (RCT) NAVA versus pressure support ventilation (PSV) in critically ill adults at risk prolonged mechanical (MV). An open-label, parallel, RCT (n = 78) four ICUs one university-affiliated hospital. primary outcome mode adherence (percentage time adherent assigned mode), protocol compliance...
Nowadays, ultrasound-guidance is commonly used in regional anaesthesia (USGRA) and to locate the spinal anatomy neuraxial analgesia. The aim of this second guideline on PERi-operative uSE UltraSound (PERSEUS-RA) provide evidence as which areas use ultrasound guidance should be considered a gold standard or beneficial patient. PERSEUS Taskforce members were asked define relevant outcomes rank relative importance following GRADE process. Whenever literature was not able enough evidence, we...
Mesenchymal stromal cells (MSCs) may be of benefit in acute respiratory distress syndrome (ARDS) due to immunomodulatory, reparative, and antimicrobial actions. ORBCEL-C is a population CD362 enriched umbilical cord-derived MSCs. The REALIST phase 1 trial investigated the safety feasibility patients with moderate severe ARDS.REALIST was an open label, dose escalation which cohorts mechanically ventilated ARDS received increasing doses (100, 200 or 400 × 106 cells) single intravenous infusion...